Results 281 to 290 of about 183,492 (354)

Effects of High‐ and Low‐Fat Meals on the Bioavailability and Pharmacokinetics of Votoplam, a HTT Gene Splicing Modifier

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Votoplam is a novel, orally bioavailable, small molecule HTT gene splicing modifier that is being developed for the treatment of Huntington's disease. This was a single dose, open‐label, two‐period, crossover food effect study that evaluated the effect of high‐ and low‐fat meals on 20 mg votoplam in healthy participants. There was a washout of
Lucy Lee, Amy‐Lee Richards, Nageswara Reddy, Brian Beers, Lee Golden, Ronald Kong   +5 more
wiley   +1 more source

Role of gut microbiota dysbiosis in the pathogenesis of non-alcoholic fatty liver disease among obese individuals. [PDF]

Bioinformation
Prasad Vudathaneni VK, Nadella SB, Mogallapu R, Varaprasad Movva K, Boyapati R.   +4 more
europepmc   +1 more source

Synthesis of Trifluoromethylated Analogues of the Cyclic Lipopeptide Iturin A and Evaluation of their Antifungal Activity

ChemPlusChem, EarlyView.
Iturin A is an antifungal lipopeptide with broad applications. Here, we present a novel synthesis and semisynthesis of trifluoromethylated iturin A analogues. Their antifungal activity was evaluated against Fusarium graminearum and Candida albicans.
Periklis Karamanis, Matthew Kiernan, Jimmy Muldoon, Paul Evans, Cormac D. Murphy, Marina Rubini   +5 more
wiley   +1 more source

Concerns and recommendations: antiplatelet agents and cancer prevention in non-alcoholic fatty liver disease. [PDF]

Front Oncol
Pham HT, Truong-Nguyen KH, Tran MH.
europepmc   +1 more source

Rodent monocyte‐derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians

Developmental Dynamics, EarlyView.
Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito, Yukio Fujiwara, Yasuka L. Yamaguchi, Satomi S. Tanaka, Kyoko Miura, Yoshiyuki Hizukuri, Kyoko Yamashiro, Yasuhiro Hayashi, Yuta Nakashima, Yoshihiro Komohara   +9 more
wiley   +1 more source

The relationship between tobacco and non-alcoholic fatty liver disease incidence: a systematic review and meta-analysis of observational studies. [PDF]

Front Med (Lausanne)
Jin J, Zhang Y, Huang Y.
europepmc   +1 more source

The Influence of Omega‐3 Fatty Acids and Probiotics on Hippocampal Inflammation and Glial Cells in a Chronic Anorexia Nervosa Rat Model

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe eating disorder associated with brain volume reduction, glial cell loss, microbiome alterations, and dysregulated pro‐inflammatory mechanisms. However, the underlying cellular mechanisms remain inadequately elucidated, and interventions addressing these alterations are lacking.
A. C. Thelen, N. Andreani, N. M. Korten, M. Neumann, V. Verspohl, M. van Egmond, L. Kneisel, C. Voelz, L. Blischke, J. F. Baines, J. Baier, J. Schumacher, F. Kiessling, B. Herpertz‐Dahlmann, C. Beyer, L. Keller, J. Seitz, S. Trinh   +17 more
wiley   +1 more source

Baicalin mitigates polycystic ovary syndrome‑associated non‑alcoholic fatty liver disease by inhibiting the AR/SREBP1 axis. [PDF]

Int J Mol Med
Jin BH, Xu H, Zhang ZY, Fan YH, Jiang CY, Qi SL, Xiao CY, Fu XH, Qian LB.   +8 more
europepmc   +1 more source

Predictive value of having positive family history of cardiovascular disorders, diabetes mellitus, dyslipidemia, and hypertension in non-alcoholic fatty liver disease patients.

, 2013
Mohammad Ebrahim Ghamarchehreh, Hossein Khedmat, Mohsen Amini, Saeed Taheri   +3 more
openalex   +1 more source

Incidence of major cardiovascular events in patients with metabolic dysfunction‐associated steatotic liver disease in the general population

European Journal of Heart Failure, EarlyView.
Aims Major adverse cardiovascular events (MACE) related to cardiovascular disease are a major cause of death in patients with metabolic dysfunction‐associated steatotic liver disease (MASLD). We explored the impact of MASLD on incident MACE and overall mortality in the general population in Germany.
Yvonne Huber, Lea Hofmann, Jürgen H. Prochaska, Thomas Koeck, Julian Chalabi, Norbert Pfeiffer, Manfred Beutel, Konstantin Strauch, Karl J. Lackner, Oliver Tüscher, Thomas Münzel, Matthias M. Weber, Julia Weinmann‐Menke, Philipp Wild, Peter R. Galle, Jörn M. Schattenberg   +15 more
wiley   +1 more source