Results 71 to 80 of about 53,092 (237)

The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression

Nature Communications, 2021
Mechanisms that underlie the progression of non-alcoholic fatty liver disease to the more severe non-alcoholic steatohepatitis are incompletely understood.
Xinzhi Li, Bingchuan Yuan, Min Lu, Yuqin Wang, Na Ding, Chunhong Liu, Ming Gao, Zhicheng Yao, Shiyan Zhang, Yujun Zhao, Liwei Xie, Zheng Chen   +11 more
doaj   +1 more source

Binary Bacillus subtilis protects the intestinal mucosa barrier and alleviates nonalcoholic steatohepatitis

Animal Models and Experimental Medicine
Background Nonalcoholic steatohepatitis (NASH) is characterized by liver steatosis, inflammation, and even fibrosis. NASH is likely to develop into cirrhosis and liver cancer, the major causes of liver related deaths.
Donglin Liu, Pengguo Chen
doaj   +1 more source

Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mice

Scientific Reports, 2017
While gap junctions mediate intercellular communication and support liver homeostasis, connexin hemichannels are preferentially opened by pathological stimuli, including inflammation and oxidative stress.
Joost Willebrords, Bruno Cogliati, Isabel Veloso Alves Pereira, Tereza Cristina da Silva, Sara Crespo Yanguas, Michaël Maes, Veronica Mollica Govoni, Andressa Lima, Daniele Aparecida Felisbino, Elke Decrock, Marina Sayuri Nogueira, Inar Alves de Castro, Isabelle Leclercq, Luc Leybaert, Robim Marcelino Rodrigues, Mathieu Vinken   +15 more
doaj   +1 more source

Acute steatohepatitis, due to extreme metabolic dysregulation, as the first presentation of non-alcoholic fatty liver disease

Clinics and Practice, 2013
Non-alcoholic fatty liver disease (NAFLD) is a slowly progressive chronic disease, with a high prevalence among obese, dyslipidemic or diabetic people, commonly presented as an asymptomatic mild elevation of serum aminotransferases.
Georgios Kranidiotis, Angeliki Angelidi, Emmanouel Sevdalis, Thomas-Nikolaos Telios, Alexandra Gougoutsi, Andreas Melidonis   +5 more
doaj   +1 more source

Mixed steatohepatitis: more questions than answers (Part 1)

Терапевтический архив, 2020
The term steatohepatitis is used for a heterogeneous group of diseases of various etiologies, characterized by a similar morphological picture.
K. L. Raikhelson, E. A. Kondrashina, E. V. Pazenko   +2 more
doaj   +1 more source

Insulin‐like growth factor‐1 is inversely associated with liver fibrotic markers in patients with type 2 diabetes mellitus

Journal of Diabetes Investigation, 2019
Aims/Introduction Insulin‐like growth factor‐1 (IGF‐1) regulates mitochondrial function, oxidative stress, inflammation, stellate cells and insulin sensitivity in the liver, and it might be associated with liver fibrosis from non‐alcoholic ...
Shozo Miyauchi, Teruki Miyake, Masumi Miyazaki, Toru Eguchi, Tetsuji Niiya, Shin Yamamoto, Hidenori Senba, Shinya Furukawa, Bunzo Matsuura, Yoichi Hiasa   +9 more
doaj   +1 more source

Enhanced serum concentrations of transforming growth factor-beta1 in simple fatty liver: is it really benign?

Journal of Translational Medicine, 2008
Background Inside the spectrum of non-alcoholic fatty liver disease, simple fatty liver is generally thought of as being "non progressive", differently from non-alcoholic steatohepatitis, which increases in severity due to the presence of apoptosis ...
Contaldo Franco, Pasanisi Fabrizio, Chianese Domenico, Di Minno Matteo N, Tarantino Marianna, Riccio Antonio, Conca Paolo, Tarantino Giovanni, Scopacasa Francesco, Capone Domenico   +9 more
doaj   +1 more source

Hepatic Steatosis and Steatohepatitis Is the Inevitability of Mixed Genesis

Gastroenterologìa, 2014
The analysis of the etiological and pathogenetic mechanisms of formation steatosis and steatohepatitis of mixed genesis is presented. It is shown that alcohol remains one of the main etiopathogenetic factors in the development of the hepatic steatosis ...
Yu.M. Stepanov
doaj   +1 more source

Comparison of clinical, biochemical and histological features of alcoholic steatohepatitis and non-alcoholic steatohepatitis in Asian Indian patients

Indian Journal of Pathology and Microbiology, 2010
Background: Alcoholic steatohepatitis (ASH) and non-alcoholic steatohepatitis (NASH) are significant forms of liver disease and may progress to end-stage liver disease, cirrhosis and potentially malignant complications.
Singh Deepak, Rastogi Archana, Sakhuja Puja, Gondal Ranjana, Sarin Shiv   +4 more
doaj  

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source