Results 1 to 10 of about 427,403 (264)

Nonalcoholic Fatty Liver Disease [PDF]

Canadian Journal of Gastroenterology and Hepatology, 2018
According to the papers published in this special issue, NAFLD is a serious problem, which each author from their own aspect tried to clarify. Regarding the fact that NAFLD is rarely isolated and that it is correlated with obesity, diabetes type 2, polycystic ovarian syndrome, obstructive sleep apnea, and some cognitive deficits, its pathophysiology ...
Branka Filipović, Alastair Forbes, Bojan Tepeš, Dan L. Dumitraşcu   +3 more
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Melatonin attenuates cholestatic liver injury by improving bile acid metabolism in mice

陆军军医大学学报
Objective To explore the mechanism of melatonin (Mel) alleviating cholestatic liver injury in a mouse cholestasis model induced by cholic acid (CA) feeding.
ZHANG Hongjia, TAN Ya, ZHAO Nan
doaj   +1 more source

Development of a tryptophan metabolomics-based diagnostic model for hepatic encephalopathy in liver cirrhosis

European Journal of Medical Research
Background Tryptophan (TRP) metabolism is implicated in the pathogenesis of hepatic encephalopathy (HE). Abnormal TRP metabolites correlate with HE severity and may represent potential biomarkers. This study employed targeted metabolomics to characterize
Xiao Cao, Li Wang, Li Ning, Yang Hu, Nian Fu   +4 more
doaj   +1 more source

Comparative efficacy and safety of different regimens of ranibizumab for neovascular age-related macular degeneration: a network meta-analysis of randomised controlled trials

BMJ Open, 2021
Objective To give a comprehensive efficacy and safety ranking of different therapeutic regimens of ranibizumab for neovascular age-related macular degeneration (nAMD).Design A systematic review and network meta-analysis.Methods The PubMed, Embase ...
Youxin Chen, Xinyu Zhao, Lihui Meng
doaj   +1 more source

Hypertriglyceridemia and Fatty Liver : Clinical Diagnosis of Fatty Liver and Lipoprotein Profiles in Hypertriglyceridemic Patients with Fatty Liver

Journal of Atherosclerosis and Thrombosis, 1995
Fatty liver has prevailed by 14% in the healthy population of this country. The factors contributing genesis of fatty liver were gender (male), obesity, high alcohol consumption, glucose intolerance and hypertriglyceridemia. And hypertriglyceridemia seems to be the common underlying factor to all other causes.
Osono, Yasunori, Nakajima, Kumiko, Hata, Yoshiya   +2 more
openaire   +3 more sources

Infections increase the risk of decompensation and death in patients with early alcohol-related liver disease

JHEP Reports
Background & Aims: Infections are frequent in patients with cirrhosis and worsen prognosis. We evaluated the incidence of infections and their impact on decompensation and death in patients with early alcohol-related liver disease (ALD) during long ...
Stine Johansen, Simon Langkjær, Ditlev Nytoft Rasmussen, Mads Israelsen, Nikolaj Torp, Katrine Lindvig, Maria Kjærgaard, Johanne Kragh Hansen, Camilla Dalby Hansen, Katrine Thorhauge, Peter Andersen, Sönke Detlefsen, Helene Bæk Juel, Ulrik Stenz Justesen, Torben Hansen, Aleksander Krag, Maja Thiele, Ema Anastasiadou, Manimozhian Arumugam, Peer Bork, Torben Hansen, Jenny Presto, Hans Israelsen, Morten Karsdal, Cristina Legido-Quigley, Hans Olav Melberg, Maja Thiele, Jonel Trebicka, Aleksander Krag, Peer Bork, Mathias Mann, Jelle Matthijnssens, Aleksander Krag, Torben Hansen   +33 more
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Impact of variations in fatty liver on sonographic detection of focal hepatic lesions originally identified by CT [PDF]

Ultrasonography, 2016
Purpose: The aim of this study was to investigate the influence of variations in fatty liver on the ultrasonographic detection of focal liver lesions. Methods: A total of 229 patients with varying degrees of fatty liver and focal liver lesions and 200 ...
Size Wu, Rong Tu, Ruixia Nan, Guangqing Liu, Xiaojing Cui, Xian Liang   +5 more
doaj   +1 more source

Fibrosis activity vs. disease stage: Complementary and independent predictors of outcomes in alcohol-related liver disease

JHEP Reports
Background & Aims: Excessive alcohol consumption accelerates fibrosis progression in steatotic liver disease. Disease activity can be described by fibrogenic activity, of which collagen formation is a central process. Type III collagen formation (PRO-
Stine Johansen, Mads Israelsen, Katrine Holtz Thorhauge, Johanne Kragh Hansen, Camilla Dalby Hansen, Helle Lindholm Schnefeld, Peter Andersen, Ida Villesen, Katrine Tholstrup Bech, Sönke Detlefsen, Nikolaj Torp, Diana Leeming, Maja Thiele, Aleksander Krag, Morten Karsdal   +14 more
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Navigating hepatotoxicity of antibody-drug conjugates: from mechanistic insights to clinical and postmarketing evidence

Frontiers in Pharmacology
Antibody-drug conjugates (ADCs) are rapidly developing targeted cancer therapeutic agents that combine specific monoclonal antibodies with cytotoxic agents. Currently, 17 ADCs are approved for the global market for treating hematological and solid tumors
Yinuo Dong, Yang Zhi, Xiaoyun Li, Xiaoyun Li, Mingyang Ma, Minyan Ye, Sha Huang, Jieting Tang, Wei Zhong, Xiaohong Lei, Yimin Mao   +10 more
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A Prospective Study of Fatty Liver Index and Incident Hypertension: The KoGES-ARIRANG Study. [PDF]

PLoS ONE, 2015
Although non-alcoholic fatty liver disease is the hepatic manifestation of metabolic syndrome, its influence on hypertension development is poorly understood.
Ji Hye Huh, Song Vogue Ahn, Sang Baek Koh, Eunhee Choi, Jang Young Kim, Ki-Chul Sung, Eung Ju Kim, Jeong Bae Park   +7 more
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