Results 11 to 20 of about 410,402 (265)

In-depth analysis of de novo lipogenesis in non-alcoholic fatty liver disease: Mechanism and pharmacological interventions

Liver Research, 2023
Non-alcoholic fatty liver disease (NAFLD) is characterized by the abnormal buildup of lipids in the liver tissue. Non-alcoholic fatty liver (NAFL) may progress to non-alcoholic steatohepatitis.
Zhixian Zhu, Xiaoxun Zhang, Qiong Pan, Liangjun Zhang, Jin Chai   +4 more
doaj   +1 more source

Total fecal microbiota transplantation alleviates high-fat diet-induced steatohepatitis in mice via beneficial regulation of gut microbiota

Scientific Reports, 2017
Non-alcoholic steatohepatitis (NASH) is an epidemic metabolic disease with limited therapeutic strategies. Cumulative data support the pivotal role of gut microbiota in NASH.
Da Zhou, Qin Pan, Feng Shen, Hai-xia Cao, Wen-jin Ding, Yuan-wen Chen, Jian-gao Fan   +6 more
doaj   +1 more source

Sodium butyrate reduces high-fat diet-induced non-alcoholic steatohepatitis through upregulation of hepatic GLP-1R expression

Experimental and Molecular Medicine, 2018
Fatty liver disease: A gutsy way to prevent disease progression A treatment for non-alcoholic fatty liver disease that incorporates a metabolite found in the gut could prevent progression to a more serious liver condition. Drugs that enhance the activity
Da Zhou, Yuan-Wen Chen, Ze-Hua Zhao, Rui-Xu Yang, Feng-Zhi Xin, Xiao-Lin Liu, Qin Pan, Huiping Zhou, Jian-Gao Fan   +8 more
doaj   +1 more source

Association Between Monocyte to High-Density Lipoprotein Cholesterol Ratio and Risk of Non-alcoholic Fatty Liver Disease: A Cross-Sectional Study

Frontiers in Medicine, 2022
Background:Non-alcoholic fatty liver disease (NAFLD) is a global health problem affecting more than a quarter of the entire adult population. Both monocytes and high-density lipoprotein cholesterol (HDL-C) were found to participate in the progression of ...
Liping Wang, Liping Wang, Jinzhong Dong, Miao Xu, Li Li, Naibin Yang, Naibin Yang, Guoqing Qian, Guoqing Qian   +8 more
doaj   +1 more source

Metabolism of Fatty Livers [PDF]

Nature, 1947
EARLIER work on the metabolism of fatty livers by Ennor1 showed that the oxygen consumption and the acetoacetic acid production of liver slices from guinea pigs poisoned with carbon tetrachloride is considerably in excess of normal. Since adenosinetriphosphate is essential for the oxidation of fatty acids2, it was considered of interest to determine a ...
A H, ENNOR, L A, STOCKEN
openaire   +2 more sources

Fatty liver in childhood

World Journal of Hepatology, 2014
Fatty liver is a growing health problem worldwide. It might evolve to nonalcoholic steatohepatitis, cirrhosis and cause hepatocellular carcinoma. This disease, which has increased because of eating habits, changes in food content and lifestyle, affects people from childhood. The most important risk factors are obesity and insulin resistance.
ÖZTÜRK, YEŞİM, Soylu, Ozlem Bekem
openaire   +3 more sources

Mass in a fatty liver

Frontline Gastroenterology, 2019
A 39-year-old man was referred to our clinic for liver diseases for a liver mass incidentally found on CT done to rule out kidney stones (figure 1A). In our clinic, he was asymptomatic with regular bowel habits. He denied episodes of jaundice, did not have skin tattoos, never smoked or used illicit drugs and rarely consumed alcohol.
Dirk J van der Windt, Gregory C Wilson, Ioannis A Ziogas, Samer Tohme, Alessandro Furlan, Michael A Nalesnik, David A Geller   +6 more
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Organic Anion Transporting Polypeptide (OATP) 1B3 is a Significant Transporter for Hepatic Uptake of Conjugated Bile Acids in HumansSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims: OATP1B3/SLCO1B3 is a human liver-specific transporter for the clearance of endogenous compounds (eg, bile acid [BA]) and xenobiotics.
Qiong Pan, Guanyu Zhu, Ziqian Xu, Jinfei Zhu, Jiafeng Ouyang, Yao Tong, Nan Zhao, Xiaoxun Zhang, Ying Cheng, Liangjun Zhang, Ya Tan, Jianwei Li, Chengcheng Zhang, Wensheng Chen, Shi-Ying Cai, James L. Boyer, Jin Chai   +16 more
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Fatty liver and lipotoxicity

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2010
Fatty liver disease comprises a spectrum ranging from simple steatosis to steatohepatitis which can progress to liver cirrhosis and hepatocellular cancer. Hepatic lipotoxicity may ensue when the hepatic capacity to utilize, store and export fatty acids (FA) as triglycerides is overwhelmed.
Trauner, Michael, Arrese, Marco, Wagner, Martin   +2 more
openaire   +4 more sources

Hepatic Aquaporin 10 Expression Is Downregulated by Activated NFκB Signaling in Human Obstructive Cholestasis

Gastro Hep Advances, 2023
Background and Aims: Recent studies reported that the hepatic expression of AQP8 and AQP9 was downregulated in bile duct-ligated (BDL) rats and that overexpression of human AQP1 in the rat liver attenuated cholestasis.
Min Liao, Wenjing Yu, Qiaoling Xie, Liangjun Zhang, Qiong Pan, Nan Zhao, Ling Li, Ying Cheng, Xiaoxun Zhang, Dequn Sun, Jin Chai   +10 more
doaj   +1 more source