Results 11 to 20 of about 472,072 (313)

Fatty liver in children

Therapeutics and Clinical Risk Management, 2009
Mandana Rafeey1, Fakhrossadat Mortazavi2, Nafiseh Mogaddasi2, Ghergherehchi Robabeh2, Shamsi Ghaffari2, Alka Hasani31Liver and gastrointestinal Research Center; 2Tabriz University (Medical Science) Tabriz, Iran; 3Research Center of Infectious Diseases ...
Mandana Rafeey, Fakhrossadat Mortazavi, Nafiseh Mogaddasi, Ghergherehchi Robabeh, et al.   +4 more
doaj   +7 more sources

Artesunate improves DDC-induced cholestatic liver fibrosis through PI3K/Akt/mTOR signaling pathway in mice

陆军军医大学学报, 2023
Objective To explore the effect and molecular mechanism of artesunate (ART) on cholestatic liver fibrosis induced by 3, 5-diethoxycarbonyl-1, 4-dihydro-2, 4, 6-collidine (DDC).
TANG Wan, ZHAO Nan, ZHANG Xiaoxun, CHAI Jin   +3 more
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Screening and validation of Hub genes in bile acid-induced hepatocyte response based on transcriptome sequencing

陆军军医大学学报, 2023
Objective To screen and verify the Hub genes involved in conjugated bile acid-induced hepatocyte metabolism through transcriptome sequencing analysis. Methods Primary mouse hepatocytes were treated with taurocholic acid (TCA), and the gene expression of ...
ZHANG Mengni, ZHANG Mengni, ZHANG Xiaoxun, OUYANG Jiafeng, CHAI Jin   +4 more
doaj   +1 more source

Ammonia Scavenger Restores Liver and Muscle Injury in a Mouse Model of Non-alcoholic Steatohepatitis With Sarcopenic Obesity

Frontiers in Nutrition, 2022
Recent studies have revealed that sarcopenia is closely associated with obesity and non-alcoholic steatohepatitis (NASH). However, few attempted to explore the cause-and-effect relationship between sarcopenic obesity and NASH.
Zi-Xuan Wang, Meng-Yu Wang, Rui-Xu Yang, Ze-Hua Zhao, Ze-Hua Zhao, Feng-Zhi Xin, Yu Li, Tian-Yi Ren, Jian-Gao Fan, Jian-Gao Fan   +9 more
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Carrier-free curcumin nanoassemblies for enhancing therapy effects in inflammation related disease

Materials & Design, 2022
Hyperinflammation can lead to tissue injury, organ failure, and even fatalities by overproducing proinflammatory cytokines. The long-term safety and outstanding anti-inflammatory ability of natural products have attracted much attention, but the low ...
Liangjun Zhang, Haihan Xia, Song Du, Nan Zhao, Xiaoxun Zhang, Qiong Pan, Senlin Xu, Zhicheng He, Zeng Yi, Jin Chai   +9 more
doaj   +1 more source

Surveillance of the progression and assessment of treatment endpoints for nonalcoholic steatohepatitis [PDF]

Clinical and Molecular Hepatology, 2023
Nonalcoholic steatohepatitis (NASH) is an aggressive form of nonalcoholic fatty liver disease (NAFLD) characterized by steatosis-associated inflammation and liver injury. Without effective treatment or management, NASH can have life-threatening outcomes.
Yi-wen Shi, Jian-Gao Fan
doaj   +1 more source

Hepatocyte-targeted hyaluronic acid-polyethyleneimine conjugates for acute liver injury therapy by ROS elimination and inflammation modulation

Materials & Design, 2023
Acute liver injury (ALI) is one of the most important causes of liver failure, and there are no FDA-approved drugs that could therapy late-stage ALI. It has been shown in this study that HA-PEI, a molecule formed by covalently combining HA and PEI, can ...
Mingqiao Li, Hedan Xu, Nan Zhao, Liangjun Zhang, Haihan Xia, Xiaoxun Zhang, Qiao Li, Min Liao, Qiong Pan, Zeng Yi, Jin Chai   +10 more
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Unique DUOX2+ACE2+ small cholangiocytes are pathogenic targets for primary biliary cholangitis

Nature Communications, 2023
The aetiology of primary biliary cholangitis (PBC) remains unclear. Here, the authors find that the numbers of DUOX2 + ACE2 + small cholangiocytes in human and mouse livers are inversely associated with disease severity, and present data indicating that ...
Xi Li, Yan Li, Jintao Xiao, Huiwen Wang, Yan Guo, Xiuru Mao, Pan Shi, Yanliang Hou, Xiaoxun Zhang, Nan Zhao, Minghua Zheng, Yonghong He, Jingjing Ding, Ya Tan, Min Liao, Ling Li, Ying Peng, Xuan Li, Qiong Pan, Qiaoling Xie, Qiao Li, Jianwei Li, Ying Li, Zhe Chen, Yongxiu Huang, David N. Assis, Shi-Ying Cai, James L. Boyer, Xuequan Huang, Can-E Tang, Xiaowei Liu, Shifang Peng, Jin Chai   +32 more
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Regulation of Lipid Metabolism by Lamin in Mutation-Related Diseases

Frontiers in Pharmacology, 2022
Nuclear lamins, known as type 5 intermediate fibers, are composed of lamin A, lamin C, lamin B1, and lamin B2, which are encoded by LMNA and LMNB genes, respectively.
Yue Peng, Qianyu Tang, Fan Xiao, Nian Fu, Nian Fu   +4 more
doaj   +1 more source

Elevated endotoxin levels in non-alcoholic fatty liver disease [PDF]

, 2010
Background: Emerging data indicate that gut-derived endotoxin may contribute to low-grade systemic inflammation in insulin resistant states. This study aimed to examine the importance of serum endotoxin and inflammatory markers in non-alcoholic fatty ...
Ashour, E., Steven J Creely, Youssef-Elabd, E., Youssef-Elabd, Elham M., Harte, A., Abdalla, M., Creely, S., Ashour Esmat, da Silva, Nancy F., McTernan Philip G, Mohga S Abdalla, Day, C.P., Day, Christopher Paul, Billyard, T., Burt, Alastair D., Burt Alastair D, Philip G McTernan, Kumar, S., Elham M Youssef-Elabd, da Silva, N.F., Alison L Harte, Burt, A.D., Nancy F da Silva, Amin, Ashraf I., Tripathi, Gyanendra, Sharada, H., Burt, A., McTernan, P. G., Billyard, Thomas, da Silva, N., Harte, A.L., Day Christopher P, Youssef-Elabd Elham M, Tripathi Gyanendra, Alastair D Burt, Sharada, Hayat M., Hayat M Sharada, Kumar Sudhesh, Abdalla Mohga S, Sharada, H.M., Day, C., Abdalla, Mohga S., Sudhesh Kumar, Creely, S.J., McGee Kirsty C, Esmat Ashour, McTernan, P., Abdalla, M.S., Tripathi, G., McGee, K.C., Youssef-Elabd, E.M., Kirsty C McGee, Christopher P Day, Ashour, Esmat, McGee, K., Billyard Thomas, Gyanendra Tripathi, Thomas Billyard, Kumar, Sudhesh, Amin Ashraf I, Amin, A., da Silva Nancy F, Harte, A. L., Ashraf I Amin, McTernan, P.G., Creely, Steven J., McGee, K. C., Harte Alison L, Creely Steven J, Sharada Hayat M, Amin, A.I.   +70 more
core   +1 more source