Results 41 to 50 of about 1,719,926 (258)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Feasibility study and reference values of FibroScan 502 with M probe in healthy preschool children aged 5 years

BMC Pediatrics, 2019
Background Transient elastography (TE) using FibroScan with M probe has been widely used in adults for controlled attenuation parameter (CAP) and liver stiffness measurement (LSM).
Jing Zeng, Xi Zhang, Chao Sun, Qin Pan, Wen-Yi Lu, Qian Chen, Li-Su Huang, Jian-Gao Fan   +7 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Liver injury in COVID-19 patients with non-alcoholic fatty liver disease: an update

, 2023
: The coronavirus disease 2019 (COVID-19) pandemic has revolutionized the priorities of the medical society worldwide. Although most patients infected with SARS-CoV-2 exhibit respiratory symptoms, other organs may also be involved, including the liver ...
Miranda, Cesare, Da Porto, Andrea, Garlatti, Elena, Tonizzo, Maurizio, Zanette, Giorgio, Rinaldo, Elena, Grazioli, Silvia, Elena Garlatti, Giorgio Zanette, Cesare Miranda, Silvia Grazioli, Andrea Da Porto, Elena Rinaldo, Maurizio Tonizzo   +13 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Melatonin attenuates cholestatic liver injury by improving bile acid metabolism in mice

陆军军医大学学报
Objective To explore the mechanism of melatonin (Mel) alleviating cholestatic liver injury in a mouse cholestasis model induced by cholic acid (CA) feeding.
ZHANG Hongjia, TAN Ya, ZHAO Nan
doaj   +1 more source

Non-alcoholic fatty liver disease is associated with an increased incidence of atrial fibrillation in patients with type 2 diabetes

, 2013
BackgroundThe relationship between non-alcoholic fatty liver disease (NAFLD) and atrial fibrillation (AF) in type 2 diabetes is currently unknown. We examined the relationship between NAFLD and risk of incident AF in people with type 2 diabetes.Methods ...
Zoppini Giacomo, S. Rodella, Filippo Valbusa, Mantovani William, Mantovani, W., BARBIERI, Enrico, Bertolini Lorenzo, ZOPPINI, Giacomo, L. Zenari, Byrne Christopher D., Zoppini, G., Giacomo Zoppini, Stefano Bonapace, Byrne, Christopher D., Stefano Rodella, Bertolini, L., CD Byrne, Bonapace Stefano, Giovanni Targher, L. Bertolini, Targher, G., Bonapace, S., Valbusa, F., Targher Giovanni, Christopher D Byrne, TARGHER, Giovanni, F. Valbusa, Barbieri, E., MANTOVANI, William, Barbieri Enrico, Rodella, S., Enrico Barbieri, Valbusa Filippo, Luciano Zenari, Zenari, L., William Mantovani, Rodella Stefano, Lorenzo Bertolini, Zenari Luciano, S. Bonapace   +39 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

CMFRI's Natural remedy for fatty liver disease from seaweeds Odisha TV dated 27th September 2022 [PDF]

, 2022
The Central Marine Fisheries Research Institute has come up with a nutraceutical product from select seaweeds to treat non-alcoholic fatty liver disease (NAFLD).
CMFRI, Library
core   +1 more source