Results 51 to 60 of about 1,719,926 (258)

Development of a tryptophan metabolomics-based diagnostic model for hepatic encephalopathy in liver cirrhosis

European Journal of Medical Research
Background Tryptophan (TRP) metabolism is implicated in the pathogenesis of hepatic encephalopathy (HE). Abnormal TRP metabolites correlate with HE severity and may represent potential biomarkers. This study employed targeted metabolomics to characterize
Xiao Cao, Li Wang, Li Ning, Yang Hu, Nian Fu   +4 more
doaj   +1 more source

Performance of Biomarkers FibroTest, ActiTest, SteatoTest, and NashTest in Patients with Severe Obesity: Meta Analysis of Individual Patient Data [PDF]

, 2012
Background Liver biopsy is considered as the gold standard for assessing non-alcoholic fatty liver disease (NAFLD) histologic lesions in patients with severe obesity.
Mathurin, Philippe, Karine Clement (2245), Poynard, Thierry, Charlotte, Frederic, Guillaume Lassailly, Emmanuel Diaz, Philippe Mathurin (177542), Caıazzo, Robert, Demol, Bernard, Tordjman, Joan, Guillaume Lassailly (177527), François Pattou, Pierre Bedossa, Perazzo Hugo, Vlad Ratziu (38088), Robert Callafe (177536), Bedossa, Pierre, Ratziu, Vlad, Clement Karine, Charlotte Frederic, Munteanu Mona, Bernard Demol (177533), Pattou, François, FLIP consortium, Frederic Charlotte (43075), Pierre Bedossa (48266), Emmanuel Diaz (177528), Thierry Poynard (38084), Lassailly, Guillaume, Joan Tordjman (48258), Lassailly Guillaume, Bernard Demol, Mathurin Philippe, Tordjman Joan, Frederic Charlotte, Clement, Karine, Karine Clement, Joan Tordjman, Robert Caïazzo (177530), Perazzo, Hugo, Mona Munteanu (38097), Bedossa Pierre, Philippe Mathurin, Ratziu Vlad, Thierry Poynard, Mona Munteanu, Callafe Robert, Pattou François, Robert Caïazzo, Diaz Emmanuel, Hugo Perazzo (143739), Demol Bernard, Caïazzo Robert, Callafe, Robert, Munteanu, Mona, Diaz, Emmanuel, Hugo Perazzo, Robert Callafe, Vlad Ratziu, François Pattou (145757), Poynard Thierry   +60 more
core   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Comparative efficacy and safety of different regimens of ranibizumab for neovascular age-related macular degeneration: a network meta-analysis of randomised controlled trials

BMJ Open, 2021
Objective To give a comprehensive efficacy and safety ranking of different therapeutic regimens of ranibizumab for neovascular age-related macular degeneration (nAMD).Design A systematic review and network meta-analysis.Methods The PubMed, Embase ...
Youxin Chen, Xinyu Zhao, Lihui Meng
doaj   +1 more source

Mechanisms into the development of fatty liver disease: role of free fatty acids and alcohol [PDF]

, 2017
Background: Alcohol and Free fatty acids such as palmitate are known to promote liver injury. However less mechanistic information is available regarding omega fatty acids ratios with/out alcohol.
Ghazali, R.
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

CMFRI discovers natural treatment for fatty liver illness from seaweeds Agri News dated 27th September 2022 [PDF]

, 2022
The Central Marine Fisheries Study Institute (CMFRI) has developed a nutraceutical product from chosen seaweeds to treat non-alcoholic fatty liver disease (NAFLD) as part of its ongoing research into generating natural therapies from marine creatures ...
CMFRI, Library
core   +1 more source

Acute fatty liver of pregnancy. Case report

, 2020
The case of acute fatty liver of pregnancy (rare pregnancy-related disorder) with favorable outcome has been reported.
Vladimir V. Rezvan, Natalia V. Afanaseva, Leonid I. Dvoretsky, null null   +3 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source