Results 71 to 80 of about 1,719,926 (258)

Navigating hepatotoxicity of antibody-drug conjugates: from mechanistic insights to clinical and postmarketing evidence

Frontiers in Pharmacology
Antibody-drug conjugates (ADCs) are rapidly developing targeted cancer therapeutic agents that combine specific monoclonal antibodies with cytotoxic agents. Currently, 17 ADCs are approved for the global market for treating hematological and solid tumors
Yinuo Dong, Yang Zhi, Xiaoyun Li, Xiaoyun Li, Mingyang Ma, Minyan Ye, Sha Huang, Jieting Tang, Wei Zhong, Xiaohong Lei, Yimin Mao   +10 more
doaj   +1 more source

A Prospective Study of Fatty Liver Index and Incident Hypertension: The KoGES-ARIRANG Study. [PDF]

PLoS ONE, 2015
Although non-alcoholic fatty liver disease is the hepatic manifestation of metabolic syndrome, its influence on hypertension development is poorly understood.
Ji Hye Huh, Song Vogue Ahn, Sang Baek Koh, Eunhee Choi, Jang Young Kim, Ki-Chul Sung, Eung Ju Kim, Jeong Bae Park   +7 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Non-invasive tests for MetALD and alcohol-related liver diseaseKeypoints

JHEP Reports
Summary: Metabolic- and alcohol-related liver disease (MetALD) and alcohol-related liver disease (ALD) are major drivers of the global burden of cirrhosis. While metabolic dysfunction-associated steatotic liver disease (MASLD) affects nearly one-third of
Stine Johansen, Maja Thiele, Aleksander Krag   +2 more
doaj   +1 more source

Farewell to the term ‘non-alcoholic fatty liver disease’

, 2023
After years of debate, the nomenclature non-alcoholic fatty liver disease (NAFLD) has been changed to metabolic dysfunction–associated steatotic liver disease, or MASLD (figure 1).
Mortimore, G.
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Evaluating large language models' performance in answering common questions on drug-induced liver injury

JHEP Reports
Background & Aims: Drug-induced liver injury (DILI) is a complex condition often linked to medication behaviors, with patient education having a crucial role in optimizing outcomes.
Yinuo Dong, Zili Zhang, Yang Zhi, Xiaoyun Li, Tengyu Guo, Lanlan He, Shuran Zhao, Xueli Yang, Jieting Tang, Wei Zhong, Qinghui Niu, Mingyang Ma, Zuxiong Huang, Yimin Mao   +13 more
doaj   +1 more source

CMFRI comes up with natural remedy for fatty liver disease from seaweeds The Economic Times dated 27th September 2022 [PDF]

, 2022
The Central Marine Fisheries Research Institute (CMFRI) based in Kochi has come up with a nutraceutical product from select seaweeds for the treatment of non-alcoholic fatty liver disease (NAFLD).
CMFRI, Library
core   +1 more source