Results 81 to 90 of about 472,072 (313)

Fibrosis activity vs. disease stage: Complementary and independent predictors of outcomes in alcohol-related liver disease

JHEP Reports
Background & Aims: Excessive alcohol consumption accelerates fibrosis progression in steatotic liver disease. Disease activity can be described by fibrogenic activity, of which collagen formation is a central process. Type III collagen formation (PRO-
Stine Johansen, Mads Israelsen, Katrine Holtz Thorhauge, Johanne Kragh Hansen, Camilla Dalby Hansen, Helle Lindholm Schnefeld, Peter Andersen, Ida Villesen, Katrine Tholstrup Bech, Sönke Detlefsen, Nikolaj Torp, Diana Leeming, Maja Thiele, Aleksander Krag, Morten Karsdal   +14 more
doaj   +1 more source

A Prospective Study of Fatty Liver Index and Incident Hypertension: The KoGES-ARIRANG Study. [PDF]

PLoS ONE, 2015
Although non-alcoholic fatty liver disease is the hepatic manifestation of metabolic syndrome, its influence on hypertension development is poorly understood.
Ji Hye Huh, Song Vogue Ahn, Sang Baek Koh, Eunhee Choi, Jang Young Kim, Ki-Chul Sung, Eung Ju Kim, Jeong Bae Park   +7 more
doaj   +1 more source

Growth inhibition and morphologic changes of HeLa cells exposed to unsaturated fatty acid fraction from the liver of x-ray irradiated rabbits (OX)

, 1962
Biological effect of the unsaturated fatty acid fraction from the X-ray irradiated rabbit liver (OX) on HeLa cells has been observed in vitro comparing with the effect displayed on the same strain cells by the unsaturated fatty acid fraction from the non-
Yamamoto, Michio, Utsumi, Kozo, Seno, Satimaru   +2 more
core   +1 more source

Induction of lipid oxidation by polyunsaturated fatty acids of marine origin in small intestine of mice fed a high-fat diet [PDF]

, 2009
Background. Dietary polyunsaturated fatty acids (PUFA), in particular the long chain marine fatty acids docosahexaenoic (DHA) and eicosapentaenoic (EPA), are linked to many health benefits in humans and in animal models.
Schothorst, E.M., van, Evert M van Schothorst, Annelies Bunschoten, Jaap Keijer, van Schothorst, E.M., Molthoff, J.W., Keijer, J., Flachs, P., Bunschoten, A., Kopecky, J., Vink, C., Franssen-Hal, N.L.W., van, van Franssen-Hal, N.L.W., Ondrej Kuda, Carolien Vink, Nicole LW Franssen-van Hal, Guido JEJ Hooiveld, Pavel Flachs, Kuda, O., Hooiveld, G.J.E.J., Jan Kopecky, Jos Molthoff   +21 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Navigating hepatotoxicity of antibody-drug conjugates: from mechanistic insights to clinical and postmarketing evidence

Frontiers in Pharmacology
Antibody-drug conjugates (ADCs) are rapidly developing targeted cancer therapeutic agents that combine specific monoclonal antibodies with cytotoxic agents. Currently, 17 ADCs are approved for the global market for treating hematological and solid tumors
Yinuo Dong, Yang Zhi, Xiaoyun Li, Xiaoyun Li, Mingyang Ma, Minyan Ye, Sha Huang, Jieting Tang, Wei Zhong, Xiaohong Lei, Yimin Mao   +10 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Fatty liver syndrome in captive bustards: Clinical, pathological and epidemiological findings

, 1997
Clinical, pathological, and epidemiological findings are presented on fatty liver syndrome mainly in houbara bustards (Chlamydotis undulata macqueenii), but also in some other bustard species.
Nicholls, P.K., Bailey, T.A., Samour, J.A.   +2 more
core  

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source