Results 21 to 30 of about 472,072 (313)

Therapeutic effect and autophagy regulation of myriocin in nonalcoholic steatohepatitis

Lipids in Health and Disease, 2019
Background Ceramide plays pathogenic roles in nonalcoholic fatty liver disease (NAFLD) via multiple mechanisms, and as such inhibition of ceramide de novo synthesis in the liver may be of therapeutically beneficial in patients with NAFLD.
Rui-Xu Yang, Qin Pan, Xiao-Lin Liu, Da Zhou, Feng-Zhi Xin, Ze-Hua Zhao, Rui-Nan Zhang, Jing Zeng, Liang Qiao, Chun-Xiu Hu, Guo-Wang Xu, Jian-Gao Fan   +11 more
doaj   +1 more source

Adipokines and redox signaling: impact on fatty liver disease. [PDF]

, 2011
Adipokines (adipose tissue cytokines) are polypeptide factors secreted by adipose tissue in a highly regulated manner. The 'classical' adipokines (leptin, adiponectin, and resistin) are expressed only by adipocytes, but other adipokines have been shown ...
Marra, Fabio., Parola, Maurizio, Parola, Maurizio.   +2 more
core   +1 more source

Fibrotic Burden in the Liver Differs Across Metabolic Dysfunction-Associated Fatty Liver Disease Subtypes [PDF]

, 2023
Background/aims: Metabolic dysfunction-associated fatty liver disease (MAFLD) is categorized into three subtypes: overweight/obese (OW), lean/normal weight with metabolic abnormalities, and diabetes mellitus (DM).
임태섭, 김승업, 김자경
core   +1 more source

In-depth analysis of de novo lipogenesis in non-alcoholic fatty liver disease: Mechanism and pharmacological interventions

Liver Research, 2023
Non-alcoholic fatty liver disease (NAFLD) is characterized by the abnormal buildup of lipids in the liver tissue. Non-alcoholic fatty liver (NAFL) may progress to non-alcoholic steatohepatitis.
Zhixian Zhu, Xiaoxun Zhang, Qiong Pan, Liangjun Zhang, Jin Chai   +4 more
doaj   +1 more source

Glucokinase links Kruppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease [PDF]

, 2011
The polymorphism, KLF6-IVS1-27A, in the Krüppel-like factor 6 (KLF6) transcription factor gene enhances its splicing into antagonistic isoforms and is associated with delayed histological progression of nonalcoholic fatty liver disease (NAFLD).
Gastaldelli, Amalia, Lee, Y., Isabel Fiel, Elisabetta Bugianesi, Miele, L., Lee, U., Bugianesi, E., Emma Buzzigoli, Andrea Mari, Pascoe, L., Mark Walker, Christopher P. Day, Burt, Alastair D., Walker, M., Bechmann, L., Hui, Kei Y, Fiel, I., Buzzigoli, E., Bechmann, Lars P., Miele, Luca, Fiel, Isabel., Luca Miele, Mari, Andrea, Patman, G., Ursula Muñoz, Day, Christopher P., Vetter, Diana., Burt, A., Lee, Young-Min., Munoz, Ursula., Hannivoort, Rebekka A., Alastair D. Burt, Amalia Gastaldelli, Walker, Mark., Agius, Loranne, Mari, A., Agius, Loranne., et al., Buzzigoli, Emma, Walker, Mark, Loranne Agius, Scott L. Friedman, Lee, Young-Min, Pascoe, Laura., Miele, Luca., Munoz, Ursula, Hui, K., Day, C., Laura Pascoe, Pascoe, Laura, Gastaldelli, Amalia., Fiel, Isabel, Ursula E. Lee, Gillian L. Patman, Munoz, U., Kei Y. Hui, Agius, L., Mari, Andrea., Vetter, D., Demetrio Ciociaro, Ciociaro, D., Buzzigoli, Emma., Lars P. Bechmann, Helen L. Reeves, Patman, Gillian L., Hannivoort, Rebekka A ., Ciociaro, Demetrio, Ciociaro, Demetrio., Mu?oz, Ursula, Bugianesi, Elisabetta, Diana Vetter, Reeves, Helen L., Hannivoort, R., Lee, Ursula E., Rebekka A. Hannivoort, Bugianesi, Elisabetta., Young-Min Lee, Vetter, Diana, Hui, Kei Y., Friedman, Scott L., Gastaldelli, A.   +80 more
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Total fecal microbiota transplantation alleviates high-fat diet-induced steatohepatitis in mice via beneficial regulation of gut microbiota

Scientific Reports, 2017
Non-alcoholic steatohepatitis (NASH) is an epidemic metabolic disease with limited therapeutic strategies. Cumulative data support the pivotal role of gut microbiota in NASH.
Da Zhou, Qin Pan, Feng Shen, Hai-xia Cao, Wen-jin Ding, Yuan-wen Chen, Jian-gao Fan   +6 more
doaj   +1 more source

Sodium butyrate reduces high-fat diet-induced non-alcoholic steatohepatitis through upregulation of hepatic GLP-1R expression

Experimental and Molecular Medicine, 2018
Fatty liver disease: A gutsy way to prevent disease progression A treatment for non-alcoholic fatty liver disease that incorporates a metabolite found in the gut could prevent progression to a more serious liver condition. Drugs that enhance the activity
Da Zhou, Yuan-Wen Chen, Ze-Hua Zhao, Rui-Xu Yang, Feng-Zhi Xin, Xiao-Lin Liu, Qin Pan, Huiping Zhou, Jian-Gao Fan   +8 more
doaj   +1 more source

Association Between Monocyte to High-Density Lipoprotein Cholesterol Ratio and Risk of Non-alcoholic Fatty Liver Disease: A Cross-Sectional Study

Frontiers in Medicine, 2022
Background:Non-alcoholic fatty liver disease (NAFLD) is a global health problem affecting more than a quarter of the entire adult population. Both monocytes and high-density lipoprotein cholesterol (HDL-C) were found to participate in the progression of ...
Liping Wang, Liping Wang, Jinzhong Dong, Miao Xu, Li Li, Naibin Yang, Naibin Yang, Guoqing Qian, Guoqing Qian   +8 more
doaj   +1 more source

Insulin sensitisers in the treatment of non-alcoholic fatty liver disease : a systematic review [PDF]

, 2011
Non-alcoholic fatty liver disease (NAFLD) is closely linked with obesity and the prevalence of NAFLD is about 17% to 33% in the Western world. There is a strong association of NAFLD with insulin resistance and, hence, insulin sensitisers have been tried.
C Clar, Henderson, R., Gurung, T., N Waugh, N Sattar, N Ghouri, Clar, C., Sattar, Naveed, Sattar, N., Fraser, A., T Gurung, Gurung, T. (Tara), D Shyangdan, A Fraser, Shyangdan, D., D Preiss, Waugh, Norman, Shyangdan, D. (Deepson), R Henderson, Ghouri, N., Preiss, D., Waugh, N.   +21 more
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Metabolism of Fatty Livers [PDF]

Nature, 1947
EARLIER work on the metabolism of fatty livers by Ennor1 showed that the oxygen consumption and the acetoacetic acid production of liver slices from guinea pigs poisoned with carbon tetrachloride is considerably in excess of normal. Since adenosinetriphosphate is essential for the oxidation of fatty acids2, it was considered of interest to determine a ...
A H, ENNOR, L A, STOCKEN
openaire   +2 more sources