Results 131 to 140 of about 12,856,242 (214)

New biosensors and transgenic mice for multiplex cGMP imaging

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters   +6 more
wiley   +1 more source

Receptor kinetics: Binding flux‐based approaches offer complementary insight into how ligand binding evolves with time

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Binding kinetics are essentially based on rate constants. Yet, this view has been challenged by the idea that ‘binding fluxes’ are dynamic and therefore more relevant. Those fluxes refer to the rate at which a target/receptor changes from one state into another through ligand/drug binding or a conformational change.
Georges Vauquelin   +2 more
wiley   +1 more source

Survey on differential estimators for 3d point clouds

open access: yesComputer Graphics Forum, EarlyView.
Abstract Recent advancements in 3D scanning technologies, including LiDAR and photogrammetry, have enabled the precise digital replication of real‐world objects. These methods are widely used in fields such as GIS, robotics, and cultural heritage. However, the point clouds generated by such scans are often noisy and unstructured, posing challenges for ...
Léo Arnal–Anger   +4 more
wiley   +1 more source

The Truth, the Whole Truth, and Nothing but the Truth: Automatic Visualization Evaluation from Reconstruction Quality

open access: yesComputer Graphics Forum, EarlyView.
Abstract Recent advances in AI enable the automatic generation of visualizations directly from textual prompts using agentic workflows. However, visualizations produced via one‐shot generative methods often suffer from insufficient quality, typically requiring a human in the loop to refine the outputs.
Roxana Bujack   +4 more
wiley   +1 more source

Scalable Computation of Topological Abstractions for Scalar Data

open access: yesComputer Graphics Forum, EarlyView.
Abstract Topological data analysis has become an important tool for large scale scalar data analysis and visualization, efficiently extracting the inherent structure and features of interest of the data. However, with growing dataset sizes and complexity, it is increasingly becoming infeasible to compute topological abstractions of interest in serial ...
M. Will   +6 more
wiley   +1 more source

Ventilatory efficiency: Physiological modelling and mechanistic validation. [PDF]

open access: yesJ Physiol
Muller PT   +5 more
europepmc   +1 more source

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