Results 101 to 110 of about 12,495,287 (348)

Earth orbital teleoperator system man-machine interface evaluation [PDF]

The teleoperator system man-machine interface evaluation develops and implements a program to determine human performance requirements in teleoperator ...
Brye, R. G., Kirkpatrick, M., Malone, T. B., Shields, N. L.   +3 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Historical and theoretical justification of Movement of non-alignment

Vestnik MGIMO-Universiteta, 2013
In the article the author draws attention to the subject of the Non-Aligned Movement, examines key periods of its evolvement as well as compares various points of view on the role and place of the Non-Aligned Movement in the contemporary world.
I. I. Pavlov
doaj   +1 more source

A kinematic study of Open Clusters: implications for their origin

, 2010
The Galactic population of open clusters provides an insight into star formation in the Galaxy. The open cluster catalogue by Dias et al.(2002b) is a rich source of data, including kinematic information.
Allen, Binney, Binney, Bovy, Carraro, Carraro, Comerón, D. Vande Putte, Danly, De La Fuente Marcos, De La Fuente Marcos, Dehnen, Dias, Dias, Dias, Durgapal, Elmegreen, ESA, Fellhauer, Fellhauer, Finch, Friel, Friel, Frinchaboy, Fu, Hernquist, Høg, I. Ferreras, Johnson, Karttunen, Kharchenko, Kharchenko, Kharchenko, Lasker, Law, Levy, Loktin, Lépine, MacMinn, Magrini, Mark Cropper, Martos, Mermilliod, Mermilliod, Miyamoto, Monet, Paunzen, Perryman, Pfalzner, Piskunov, R. P. Mignani, Roeser, Schlegel, Schönrich, Sparke, T. P. Garnier, Twarog, Van Leeuwen, Vande Putte, Vande Putte, Wakker, Wallin, Wu, Yong, Zacharias, Zacharias   +65 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The Production of Liminal Spaces in the Liberal International Order: An Analysis from the Perspective of Brazil’s Non-Alignment Towards the War in Ukraine

Polish Political Science Yearbook
Brazil’s position towards the War in Ukraine sheds light on fundamental ambiguities of Brazil’s contemporary self-representations. While Brazil has traditionally defined itself in relation to its identification with the West, it has simultaneously ...
Marta Fernández, Maíra Siman Gomes, Francine Rossone   +2 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

India and the Indo-Pacific an emerging regional vision [PDF]

This report looks at India and the continuing change in political and trade influences in the Indo-Pacific region and the possible effects it will have on existing political powers such as the United States of America and Australia.
Priya Chacko
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source