Results 71 to 80 of about 24,186,788 (290)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

High prevalence and diversity of HIV-1 non-B genetic forms due to immigration in southern Spain: A phylogeographic approach.

PLoS ONE, 2017
Phylogenetic studies are a valuable tool to understand viral transmission patterns and the role of immigration in HIV-1 spread. We analyzed the spatio-temporal relationship of different HIV-1 non-B subtype variants over time using phylogenetic analysis ...
Santiago Pérez-Parra, Natalia Chueca, Marta Álvarez, Juan Pasquau, Mohamed Omar, Antonio Collado, David Vinuesa, Ana Belen Lozano, Gonzalo Yebra, Federico García   +9 more
doaj   +1 more source

Compositional changes of B and T cell subtypes during fingolimod treatment in multiple sclerosis patients: a 12-month follow-up study. [PDF]

PLoS ONE, 2014
BACKGROUND AND OBJECTIVE: The long term effects of fingolimod, an oral treatment for relapsing-remitting (RR) multiple sclerosis (MS), on blood circulating B and T cell subtypes in MS patients are not completely understood.
Nele Claes, Tessa Dhaeze, Judith Fraussen, Bieke Broux, Bart Van Wijmeersch, Piet Stinissen, Raymond Hupperts, Niels Hellings, Veerle Somers   +8 more
doaj   +1 more source

Comparison of Drug Resistance Scores for Tipranavir in Protease Inhibitor-Naïve Patients Infected with HIV-1 B and Non-B Subtypes

, 2011
Genotypes of samples from protease inhibitor-naïve patients in Frankfurt's HIV Cohort were analyzed with five tipranavir resistance prediction algorithms. Mean scores were higher in non-B than in B subtypes.
Hans-Reinhard Brodt, Christoph Stephan, Margriet van Houtte, Markus Bickel, Lutz Gürtler, Pierre Lecocq, Peter Gute, Martin Stürmer, Gaby Knecht, Hans W. Doerr   +9 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Prevalence and phenotypic susceptibility to doravirine of the HIV-1 reverse transcriptase V106I polymorphism in B and non-B subtypes

Background. Limited data are available regarding the susceptibility of the reverse transcriptase V106 polymorphism to doravirine. Methods Doravirine susceptibility was measured in site-directed mutants (SDMs) containing V106I, V106A, V106M, and Y188L ...
Ceccherini-Silberstein, Francesca, de Salazar, Adolfo, Lambert-Niclot, Sidonie, Delgado, Rafael, Zazzi, Maurizio, Paraskevis, Dimitrios, Colao, Maria Grazia, Aguilera, Antonio, Malet, Isabelle, Falces-Romero, Iker, Viñuela, Laura, Saladini, Francesco, Moreno, Cristina, Teyssou, Elisa, Charpentier, Charlotte, Santoro, Maria, Fuentes, Ana, Micheli, Valeria, Bertoli, Ada, Marcelin, Anne-Genevieve, Bartolini, Niccolò, Gomes, Perpetua, Fabeni, Lavinia, García, Federico, Giammarino, Federica, Sterrantino, Gaetana, Falces-Romero I., Saladini F., Bartolini N., Giammarino F., Aguilera A., Fabeni L., Colao M. G., Santoro M. M., Charpentier C., Ceccherini-Silberstein F., Teyssou E., Santoro, Maria M, Zazzi M., Vinuela L., Delgado R., Bertoli A., Gomes P., Paraskevis D., de Salazar A., Garcia F., Marcelin A. -G., Malet I., Moreno C., Fuentes A., Micheli V., Sterrantino G., Lambert-Niclot S.   +52 more
core   +4 more sources

Number of Treated and Untreated Persons Infected with B and Non-B HIV-1 Subtypes from Whom Protease and/or RT Sequences Were Available for Analysis

, 2013
Number of Treated and Untreated Persons Infected with B and Non-B HIV-1 Subtypes from Whom Protease and/or RT Sequences Were Available for ...
Lynn Morris (7883), Vincent Soriano (7880), Maria Belen Bouzas (7878), Rami Kantor (7863), Brad Efron (7865), Luis F Brigido (7881), Amilcar Tanuri (7885), Praphan Phanuphak (7886), Patricia Cane (7868), Hagit Rudich (7874), Ana Patricia Carvalho (7866), Deenan Pillay (7888), Brian Wynhoven (7867), Rosangela Rodrigues (7875), Pedro Cahn (4922), Wataru Sugiura (7879), Anne-Mieke Vandamme (7884), Marcelo A Soares (7871), P. Richard Harrigan (7889), David A Katzenstein (7864), Zehava Grossman (7882), Joke Snoeck (7872), Jonathan N Weber (7887), Africa Holguin (7876), Candice Pillay (7873), Robert W Shafer (7892), Koya Ariyoshi (7877), Jonathan M Schapiro (7891), Ricardo Camacho (7890), John Clarke (7869), Sunee Sirivichayakul (7870)   +30 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

High Tenofovir Failure Rates in an Emerging, Non-B Subtype HIV Epidemic [PDF]

Open Forum Infectious Diseases, 2017
Abstract Background The WHO-recommended regimen for antiretrovirals (ARVs) is tenofovir (TDF) + lamivudine/emtricitabine (3TC/FTC) + efavirenz (EFV), based on demonstrated superiority of TDF+FTC+EFV over zidovudine (AZT) +FTC+ EFV in clinical trials.
Salvana, Edsel Maurice, Schwem, Brian, Samonte, Genesis, Telan, Elizabeth, Tactacan-Abrenica, Rosario, Ching, Patrick, Mendoza, Kevin, Arevalo, Geraldine, Alejandria, Marissa, Leyritana, Katerina, Trinidad, Lyka, Penalosa, Christine, Lim, Jodor   +12 more
openaire   +1 more source

Kaplan–Meier estimates of breast cancer-specific survival in the luminal subtypes (A) and the non-luminal subtypes (B) and recurrence/metastasis-free survival in the luminal subtypes (C) and the non-luminal subtypes (D) according to histologic type in the general population.

, 2014
Kaplan–Meier estimates of breast cancer-specific survival in the luminal subtypes (A) and the non-luminal subtypes (B) and recurrence/metastasis-free survival in the luminal subtypes (C) and the non-luminal subtypes (D) according to histologic type in ...
Xin Hu (38924), Jian Zhou (28020), Zhi-Ming Shao (87153), Lin-Jun Yang (590715), Wen-Biao Shi (590714), Qiang Zhang (45005)   +5 more
core   +1 more source