Results 81 to 90 of about 262,938 (280)

Canonical A-to-I and C-to-U RNA editing is enriched at 3'UTRs and microRNA target sites in multiple mouse tissues. [PDF]

PLoS ONE, 2012
RNA editing is a process that modifies RNA nucleotides and changes the efficiency and fidelity of the central dogma. Enzymes that catalyze RNA editing are required for life, and defects in RNA editing are associated with many diseases. Recent advances in
Tongjun Gu, Frank W Buaas, Allen K Simons, Cheryl L Ackert-Bicknell, Robert E Braun, Matthew A Hibbs   +5 more
doaj   +1 more source

Convenient Genetic Encoding of Phenylalanine Derivatives through Their α-Keto Acid Precursors

Biomolecules, 2021
The activity and function of proteins can be improved by incorporation of non-canonical amino acids (ncAAs). To avoid the tedious synthesis of a large number of chiral phenylalanine derivatives, we synthesized the corresponding phenylpyruvic acid ...
Li Liu, Bohao Wang, Sheng Li, Fengyuan Xu, Qi He, Chun Pan, Xiangdong Gao, Wenbing Yao, Xiaoda Song   +8 more
doaj   +1 more source

Deriving amino acid contact potentials from their frequencies of occurence in proteins: a lattice model study

, 2004
The possibility of deriving the contact potentials between amino acids from their frequencies of occurence in proteins is discussed in evolutionary terms.
Abkkevich V I, Anfinsen C B, Betancourt M R, Bryngelson J D, Creighton T E, D Provasi, Derrida B, Finkelstein A V, G Tiana, Godzik A, Greiner W, Kolinski A, Li H, M Colombo, Miyazawa S, R A Broglia, Rost B, Shakhnovich E I, Shimada J, Sippl M J, Zhang L   +20 more
core   +1 more source

The PIN-FORMED (PIN) protein family of auxin transporters [PDF]

, 2009
The PIN-FORMED (PIN) proteins are secondary transporters acting in the efflux of the plant signal molecule auxin from cells. They are asymmetrically localized within cells and their polarity determines the directionality of intercellular auxin flow.
Krecek, Pavel, Skupa, Petr, Libus, Jiri, Naramoto, Satoshi, Tejos Ulloa, Ricardo, Friml, Jiri, Zazimalova, Eva   +6 more
core   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Structural Dynamics of Free Proteins in Diffraction [PDF]

, 2011
Among the macromolecular patterns of biological significance, right-handed α-helices are perhaps the most abundant structural motifs. Here, guided by experimental findings, we discuss both ultrafast initial steps and longer-time-scale structural dynamics
Lin, Milo M., Shorokhov, Dmitry, Zewail, Ahmed H.   +2 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Rationally introducing non-canonical amino acids to enhance catalytic activity of LmrR for Henry reaction

Bioresources and Bioprocessing
The use of enzymes to catalyze Henry reaction has advantages of mild reaction conditions and low contamination, but low enzyme activity of promiscuous catalysis limits its application.
Lan Wang, Mengting Zhang, Haidong Teng, Zhe Wang, Shulin Wang, Pengcheng Li, Jianping Wu, Lirong Yang, Gang Xu   +8 more
doaj   +1 more source

Molecular and antigenic characterization of Trypanosoma cruzi TolT proteins [PDF]

, 2018
Background: TolT was originally described as a Trypanosoma cruzi molecule that accumulated on the trypomastigote flagellum bearing similarity to bacterial TolA colicins receptors.
Agüero, Fernan Gonzalo, Altcheh, Jaime Marcelo, Balouz, Virginia, Buscaglia, Carlos Andres, Camara, María de los Milagros, Campetella, Oscar Eduardo, Canepa, Gaspar Exequiel, Carlevaro, Giannina Alejandra, Carmona, Santiago Javier, Ciocchini, Andres Eduardo, Cortina, María Eugenia, Lobo, Mabel Maite, Melli, Luciano Jorge, Mucci, Juan Sebastián   +13 more
core   +1 more source

One-pot chemoenzymatic syntheses of non-canonical amino acids

Journal of Industrial Microbiology and Biotechnology
Abstract   Despite their prevalent use in drug discovery and protein biochemistry, non-canonical amino acids are still challenging to synthesize through purely chemical means. In recent years, biocatalysis has emerged as a transformative paradigm for small-molecule synthesis.
Tsung-Han Chao, Xiangyu Wu, Hans Renata
openaire   +2 more sources