Results 201 to 210 of about 114,666 (259)

Bisphenol A Induces DNA Damage and Differential Cytotoxicity in Thyroid Cells: High‐Dose Effects Challenge Regulatory Thresholds

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor, has been implicated in carcinogenesis; however, its effects on thyroid cells remain unclear. This study investigated BPA‐induced cytotoxicity and genotoxicity in thyroid cell lines, including normal follicular (Nthy‐ori 3‐1), papillary carcinoma (TPC‐1 and BCPAP) and anaplastic
Izabela Fernanda Dal' Bó, Natássia Elena Bufalo, Valdemar Máximo, Laura Sterian Ward   +3 more
wiley   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Cellular Responses to Tartrazine and Sulfanilic Acid Exposure in BEAS‐2B Cells: Viability, Apoptosis, and DNA Damage

Journal of Applied Toxicology, EarlyView.
ABSTRACT Tartrazine is a synthetic azo dye widely used in food, pharmaceutical, and cosmetic products, resulting in extensive human exposure, while its toxicity and that of its primary metabolite, sulfanilic acid, remain controversial. Considering the reported association of tartrazine with hypersensitivity and allergic‐like reactions, human bronchial ...
Merve Baysal, Abdullah Burak Karaduman, Büşra Korkut Çelikateş, Merve Güven, Özlem Atlı‐Eklioğlu, Sinem Ilgın   +5 more
wiley   +1 more source

Synthesis and Characterization of Juglone‐Derived cu (II), Mn (II) and Zn (II) Complexes and Investigation of Their Cytotoxic Activities Against Lung and Colon Cancer Cells in Vitro and in Silico

Journal of Applied Toxicology, EarlyView.
ABSTRACT Three new Zn (II), Cu (II) and Mn (II) complexes have been synthesized from 5‐hydroxy‐1,4‐naphthoquinone (HNQ). Elemental analysis, magnetic susceptibility, UV–Vis, IR and Mass spectrometry have all been used to explore the structural characterization of these compounds.
Mustafa Öztatlıcı, Turan Birimoğlu, Semih Güler, Rukiye Betül Çolaksel, Mehmet Tahir Husunet, Mehmet Sönmez   +5 more
wiley   +1 more source

Exploring the Chemical Complexity and Toxicological Behaviour of Semi‐permanent Make‐Up Pigments: A Systematic Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Semi‐permanent make‐up (SPMU), or micropigmentation, involves implanting pigments into the dermal layer of the skin for cosmetic enhancement. Unlike topical cosmetics, which are rapidly cleared from the body, SPMU pigments persist in living tissues, raising unique toxicological considerations.
T. A. N. Kaye, M. B. Komane, A. P. Manyisane, R. Manganyi   +3 more
wiley   +1 more source

Age distinguishes selection from causation in cancer genomes. [PDF]

Nat Genet
Cheek D, Blohmer M, Nowak MA, Antal T, Naxerova K.   +4 more
europepmc   +1 more source

An integration approach for health risk assessment and priority control factor identification of indoor phthalates in a plastic waste recycling plant. [PDF]

Sci Rep
Liu M, Zhao J, Yuan M, Bai J, Song X, Xu T, Yin D.   +6 more
europepmc   +1 more source

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Arsenic exposure and non-carcinogenic health effects

Human & Experimental Toxicology, 2021
Inorganic arsenic (iAs) exposure is a serious health problem that affects more than 140 million individuals worldwide, mainly, through contaminated drinking water. Acute iAs poisoning produces several symptoms such as nausea, vomiting, abdominal pain, and severe diarrhea, whereas prolonged iAs exposure increased the risk of several malignant disorders ...
Macario Martínez-Castillo, Eliud A García-Montalvo, Mónica G Arellano-Mendoza, Luz del C Sánchez-Peña, Luis E Soria Jasso, Jeannett A Izquierdo-Vega, Olga L Valenzuela, Araceli Hernández-Zavala   +7 more
openaire   +2 more sources

Non-carcinogenicity of Capsaicinoids in B6C3F1 Mice

Food and Chemical Toxicology, 1998
The carcinogenicity of a mixture of capsaicinoids (64.5% capsaicin and 32.6% dihydrocapsaicin) was examined in B6C3F1 mice. In a 13-week toxicity study, renal toxicity was observed in 1% capsaicinoid-treated males. Next, groups of 50 mice of each sex were given 0, 0.025, 0.083 or 0.25% capsaicinoids in powdered diet for 79 weeks and killed in week 83 ...
A, Akagi, N, Sano, H, Uehara, T, Minami, H, Otsuka, K, Izumi   +5 more
openaire   +2 more sources

Non-carcinogenicity of hexamethylenetetramine in mice and rats

Food and Cosmetics Toxicology, 1968
Abstract Hexamethylenetetramine (HMT) has been studied in long-term experiments for carcinogenicity in mice and rats. Mice of one outbred (CTM) and two inbred (C3Hf/Dp and SWR/Dp) strains were given 1% HMT in the drinking water for 60 wk. The CTM strain was also given 0·5% HMT for 60 wk and 5% HMT for 30 wk.
Della porta, G, Colnaghi, M, Parmiani, G
openaire   +2 more sources