Results 211 to 220 of about 114,666 (259)
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Non-carcinogenic effects of inorganic arsenic
Environmental Geochemistry and Health, 1992This review will focus primarily on ohe effects of the inorganic arsenicals (arsenate and arsenite forms) that are present in drinking water. They are acutely toxic to both humans and animals, an effect that may be related to their bioavailibility. In humans, arsenicals have been reported to cause dermatitis and mucous membrane irritation upon exposure.
C O, Abernathy, E V, Ohanian
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Non-carcinogenic effects of TCDD in animals
Food Additives & Contaminants, 2000Exposure to TCDD and related chemicals leads to a plethora of effects in multiple species, tissues, and stages of development. Responses range from relatively simple biochemical alterations through overtly toxic responses, including lethality. The spectrum of effects shows some species variability, but many effects are seen in multiple wildlife ...
L S, Birnbaum, J, Tuomisto
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Determination of a virtually non‐carcinogenic dose
Food Additives & Contaminants, 1984The various mathematical models of the dose-response relationship are briefly reviewed and it is concluded that the Weibull and gamma-multihit models are at present the best ones. They permit the computation of a 'virtually safe dose', for which the carcinogenic risk to man is reasonably negligible, but because of the unknown mechanism of the ...
R, Lowy, P, Manchon
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The genetic toxicology of Gene-Tox non-carcinogens
Mutation Research/Genetic Toxicology, 1988The Gene-Tox Program has identified 61 chemicals that have been tested in chronic rodent carcinogenesis bioassays and found to be inactive. The genetic toxicology data of these 61 non-carcinogens is reviewed and summarized. A large proportion of these chemicals have been tested to a limited extent in genetic toxicity bioassays: 32 in 2 tests or less ...
M D, Waters, H B, Bergman, S, Nesnow
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The stimulation of hydroxylation by carcinogenic and non-carcinogenic compounds
Biochemical Pharmacology, 1966Abstract Pretreatment of young rats and mice with certain drugs and polycyclic hydrocarbons stimulates the hydroxylation of biphenyl by liver microsomal preparations. Phenobarbitone, nikethamide and meprobamate, all increase the 4-hydroxylation of biphenyl but have little effect on the 2-hydroxylation.
P J, Creaven, D V, Parke
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Non-carcinogenic carbon sorbents for respiratory protection
Journal of Hazardous Materials, 2009Activated carbons impregnated with compounds of chromium, copper and silver (Cr-Cu-Ag) are widely used for removing toxic substances from air, mainly in respiratory protection for industrial and military applications. Toxicological and epidemiological studies have shown chromium (especially hexavalent Cr) to have carcinogenic properties.
Radoslaw, Szmigielski +4 more
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The non-carcinogenicity of a single dose of 4-aminobiphenyl in the dog
Food and Cosmetics Toxicology, 1968Abstract The approximate lethal oral dose of crystalline 4-aminobiphenyl (administered by capsule) is 50 mg/kg in mongrel dogs. Administration of this dose to six pure-bred beagles caused the death of two animals in 18 hr. The four surviving animals, plus two additional beagle dogs each given one oral dose of 15 mg/kg, were observed for 5 yr and ...
W B, Deichmann, W E, MacDonald
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Metabolism-mediated cytotoxicity of chemical carcinogens and non-carcinogens
Biochemical Pharmacology, 1978Abstract The results presented in this paper clearly demonstrate that a fibroblast suppression test system incorporating viable hepatocytes can be of value in studying the problems of metabolism-mediated cytotoxicity for those compounds and/or metabolites that are sufficiently stable to traverse cell membranes.
P, Wiebkin, J R, Fry, J W, Bridges
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Non-carcinogenic response to coumarin in Syrian golden hamsters
Food and Cosmetics Toxicology, 1981Abstract Groups of 11–12 male and 10–13 female Syrian golden hamsters received diets containing 0·0 (controls), 0·1 or 0·5% coumarin for up to 2 yr. In these three groups, survivors of the initial totals of 24, 24 and 21 hamsters, respectively, numbered 17, 9, and 18 at 18 months, 12, 1 and 12 at 22 months and 10, 1 and 5 at 24 months.
I, Ueno, I, Hirono
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Mutagenicity of the non-carcinogenic dibenzylnitrosamine and an alpha-acetoxy derivative
Cancer Letters, 1979The mutagenicity of a non-carcinogenic nitrosamine, N,N-dibenzylnitrosamine (I), and a chemically synthesized alpha-acetoxy derivative, N-(alpha-acetoxy-benzyl)-N-benzylnitrosamine (II), has been examined in Salmonella typhimurium TA100 and TA1535. Compound (I) was non-mutagenic when tested directly or in the presence of a metabolic activation system ...
M K, Jacobson +4 more
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