Results 101 to 110 of about 1,318,082 (335)

Regulation of Peripheral Myelination through Transcriptional Buffering of Egr2 by an Antisense Long Non-coding RNA [PDF]

, 2017
Precise regulation of Egr2 transcription is fundamentally important to the control of peripheral myelination. Here, we describe a long non-coding RNA antisense to the promoter of Egr2 (Egr2-AS-RNA).
Langer, Robert S, Martinez-Moreno, Margot, Ness, Jennifer K., O'Shea, Timothy Mark, Olaru, Alexander, Tapinos, Nikos, Zepecki, John P.   +6 more
core   +2 more sources

Emerging roles of long non‐coding RNA in cancer

Cancer Science, 2018
Since comprehensive analysis of the mammalian genome revealed that the majority of genomic products are transcribed in long non‐coding RNA (lncRNA), increasing attention has been paid to these transcripts.
Anna Sanchez Calle, Yumi Kawamura, Yusuke Yamamoto, F. Takeshita, T. Ochiya   +4 more
semanticscholar   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Quality Assessment of Domesticated Animal Genome Assemblies

Bioinformatics and Biology Insights, 2015
The era of high-throughput sequencing has made it relatively simple to sequence genomes and transcriptomes of individuals from many species. In order to analyze the resulting sequencing data, high-quality reference genome assemblies are required. However,
Stefan E. Seemann, Christian Anthon, Oana Palasca, Jan Gorodkin   +3 more
doaj   +1 more source

Co-occurrence of three different plasmids in an extensively drug-resistant hypervirulent Klebsiella pneumoniae isolate causing urinary tract infection

Journal of Global Antimicrobial Resistance, 2020
Objectives: A single carbapenem-resistant, hypervirulent Klebsiella pneumoniae strain has attracted major public concern. The aim of the present study was to better understand the antimicrobial resistance and genetic characteristics of Klebsiella ...
Xiaokui Zhu, Chuanyu Sun, Hongyin Chen, Xiaodie Zhan, Chenxin Liu, Xin Liu, Changwu Yue, Hong Song, Hongling Lu, Xu Jia   +9 more
doaj   +1 more source

NAPP: the Nucleic Acid Phylogenetic Profile Database [PDF]

, 2017
Nucleic acid phylogenetic profiling (NAPP) classifies coding and non-coding sequences in a genome according to their pattern of conservation across other genomes.
Gautheret, Daniel, Idali, Anouar, Marchais, Antonin, Ott, Alban   +3 more
core  

RNA under Tension: Folding Landscapes, Kinetic Partitioning Mechanism, and Molecular Tensegrity

, 2012
Non-coding RNA sequences play a great role in controlling a number of cellular functions, thus raising the need to understand their complex conformational dynamics in quantitative detail.
Hyeon, Changbong, Lin, Jong-Chin, Thirumalai, D.   +2 more
core   +1 more source

Methods for comprehensive experimental identification of RNA-protein interactions [PDF]

, 2014
The importance of RNA-protein interactions in controlling mRNA regulation and non-coding RNA function is increasingly appreciated. A variety of methods exist to comprehensively define RNA-protein interactions.
Guttman, Mitchell, McHugh, Colleen A., Russell, Pamela   +2 more
core   +2 more sources

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Virulence gene profiles and molecular genetic characteristics of diarrheagenic Escherichia coli from a hospital in western China

Gut Pathogens, 2018
Background Diarrheagenic Escherichia coli (DEC) is one of the most important etiological agents of diarrheal diseases. In this study we investigated the prevalence, virulence gene profiles, antimicrobial resistance, and molecular genetic characteristics ...
Dan Li, Min Shen, Ying Xu, Chao Liu, Wen Wang, Jinyan Wu, Xianmei Luo, Xu Jia, Yongxin Ma   +8 more
doaj   +1 more source