Results 71 to 80 of about 894,957 (355)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Long Non-Coding RNA in Cancer [PDF]

International Journal of Molecular Sciences, 2013
Long non-coding RNAs (lncRNAs) are pervasively transcribed in the genome and are emerging as new players in tumorigenesis due to their various functions in transcriptional, posttranscriptional and epigenetic mechanisms of gene regulation. LncRNAs are deregulated in a number of cancers, demonstrating both oncogenic and tumor suppressive roles, thus ...
Nina Hauptman, Damjan Glavač
openaire   +2 more sources

Phage Selective Pressure Reduces Virulence of Hypervirulent Klebsiella pneumoniae Through Mutation of the wzc Gene

Frontiers in Microbiology, 2021
Hypervirulent Klebsiella pneumoniae (hvKp), one of the major community-acquired pathogens, can cause invasive infections such as liver abscess. In recent years, bacteriophages have been used in the treatment of K.
Lingjie Song, Xianggui Yang, Jinwei Huang, Xiaokui Zhu, Guohui Han, Yan Wan, Ying Xu, Guangxin Luan, Xu Jia   +8 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Non-Coding RNAs and Endometrial Cancer [PDF]

Genes, 2018
Non-coding RNAs (ncRNAs) are involved in the regulation of cell metabolism and neoplastic transformation. Recent studies have tried to clarify the significance of these information carriers in the genesis and progression of various cancers and their use as biomarkers for the disease; possible targets for the inhibition of growth and invasion by the ...
Vallone C., Rigon G., Gulia C., Baffa A., Votino R., Morosetti G., Zaami S., Briganti V., Catania F., Gaffi M., Nucciotti R., Costantini F. M., Piergentili R., Putignani L., Signore F.   +14 more
openaire   +3 more sources

Role of non-coding RNAs and exosomal non-coding RNAs in retinoblastoma progression

Frontiers in Cell and Developmental Biology, 2022
Retinoblastoma (RB) is a rare aggressive intraocular malignancy of childhood that has the potential to affect vision, and can even be fatal in some children. While the tumor can be controlled efficiently at early stages, metastatic tumors lead to high mortality.
Nasrin Ahangar Davoodi, Sajad Najafi, Zari Naderi Ghale-Noie, Ashkan Piranviseh, Samaneh Mollazadeh, Sahar Ahmadi Asouri, Zatollah Asemi, Mohammadamin Morshedi, Mohammadamin Morshedi, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Amirhossein Sheida, Amirhossein Sheida, Hamed Mirzaei   +13 more
openaire   +3 more sources

The complex transcriptional landscape of the anucleate human platelet. [PDF]

, 2013
BACKGROUND: Human blood platelets are essential to maintaining normal hemostasis, and platelet dysfunction often causes bleeding or thrombosis. Estimates of genome-wide platelet RNA expression using microarrays have provided insights to the platelet ...
Bray, Paul F, Chen, Huang-Wen, Delgrosso, Kathleen, Edelstein, Leonard, Ertel, Adam, Fortina, Paolo, Jing, Yi, Kupper, Joan, Loher, Phillipe, Londin, Eric R, McKenzie, Steven E, Nagalla, Srikanth, Rigoutsos, Isidore   +12 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Non-Coding RNAs in Muscle Dystrophies [PDF]

International Journal of Molecular Sciences, 2013
ncRNAs are the most recently identified class of regulatory RNAs with vital functions in gene expression regulation and cell development. Among the variety of roles they play, their involvement in human diseases has opened new avenues of research towards the discovery and development of novel therapeutic approaches.
ERRIQUEZ, DANIELA, PERINI, GIOVANNI, Ferlini A.   +2 more
openaire   +3 more sources

miR-144/451 represses the LKB1/AMPK/mTOR pathway to promote red cell precursor survival during recovery from acute anemia

Haematologica, 2018
The microRNAs miR-144 and -451 are encoded by a bicistronic gene that is strongly induced during red blood cell formation (erythropoiesis). Ablation of the miR-144/451 gene in mice causes mild anemia under baseline conditions.
Xiao Fang, Feiyang Shen, Christophe Lechauve, Peng Xu, Guowei Zhao, Jacobi Itkow, Fan Wu, Yaying Hou, Xiaohui Wu, Lingling Yu, Huiqing Xiu, Mengli Wang, Ruiling Zhang, Fangfang Wang, Yanqing Zhang, Daxin Wang, Mitchell J. Weiss, Duonan Yu   +17 more
doaj   +1 more source