Results 51 to 60 of about 688,893 (310)
Potential treatment with Chinese and Western medicine targeting NSP14 of SARS-CoV-2
Journal of Pharmaceutical Analysis, 2021 The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a serious global health threat.
Chao Liu +5 more
doaj +1 more source
Non-Coding RNA-Dependent Regulation of Mitochondrial Dynamics in Cancer Pathophysiology
, 2023 Mitochondria are essential organelles which dynamically change their shape and number to adapt to various environmental signals in diverse physio-pathological contexts.
Nicola Amodio +3 more
core +1 more source
Long Non-Coding RNA in Cancer [PDF]
International Journal of Molecular Sciences, 2013 Long non-coding RNAs (lncRNAs) are pervasively transcribed in the genome and are emerging as new players in tumorigenesis due to their various functions in transcriptional, posttranscriptional and epigenetic mechanisms of gene regulation. LncRNAs are deregulated in a number of cancers, demonstrating both oncogenic and tumor suppressive roles, thus ...
Nina Hauptman, Damjan Glavač
openaire +2 more sources
A hepatitis C virus cis-acting replication element forms a long-range RNA-RNA interaction with upstream RNA sequences in NS5B [PDF]
, 2008 The genome of hepatitis C virus (HCV) contains cis-acting replication elements (CREs) comprised of RNA stem-loop structures located in both the 5' and 3' non-coding regions (NCR), and in the NS5B coding sequence.
Diviney, Sinéad +22 more
core +1 more source
Non-coding RNAs in the Ovarian Follicle [PDF]
Frontiers in Genetics, 2017 The mammalian ovarian follicle is the complex reproductive unit comprising germ cell, somatic cells (Cumulus and Granulosa cells), and follicular fluid (FF): paracrine communication among the different cell types through FF ensures the development of a mature oocyte ready for fertilization.
Battaglia, Rosalia +7 more
openaire +3 more sources
Functional Interplay between RNA Viruses and Non-Coding RNA in Mammals [PDF]
, 2019 Exploring virus–host interactions is key to understand mechanisms regulating the viral replicative cycle and any pathological outcomes associated with infection.
Fossat, Nicolas +5 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Non‐coding RNAs in the nervous system [PDF]
The Journal of Physiology, 2006 Increasing evidence suggests that the development and function of the nervous system is heavily dependent on RNA editing and the intricate spatiotemporal expression of a wide repertoire of non‐coding RNAs, including micro RNAs, small nucleolar RNAs and longer non‐coding RNAs.
Mehler, M. F., Mattick, J. S.
openaire +5 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Shaping the Genome with Non-Coding RNAs [PDF]
Current Genomics, 2011 The human genome must be tightly packaged in order to fit inside the nucleus of a cell. Genome organization is functional rather than random, which allows for the proper execution of gene expression programs and other biological processes. Recently, three-dimensional chromatin organization has emerged as an important transcriptional control mechanism ...
Wang, Xue Q.D +2 more
openaire +3 more sources