Results 51 to 60 of about 894,957 (355)
Non-Coding RNAs in Retinoblastoma [PDF]
Frontiers in Genetics, 2019 Retinoblastoma (Rb) is the most common ocular pediatric malignancy that arises from the retina and is caused by a mutation of the two alleles of the tumor suppressor gene, RB1. Although early detection provides the opportunity of controlling the primary tumor with effective therapies, metastatic activity is fatal.
Meropi Plousiou, Ivan Vannini
openaire +3 more sources
miR-144/451 in hematopoiesis and beyond
ExRNA, 2019 MicroRNAs (miRNAs), a class of 18–25 nucleotide (nt) non-coding RNAs, usually inhibit the expression of their target genes. They are transcribed from endogenous genes and are processed for maturation by multiple pathways.
Ting Wang, Fan Wu, Duonan Yu
doaj +1 more source
Non-Coding RNA Sequencing of Equine Endometrium During Maternal Recognition of Pregnancy. [PDF]
, 2019 Maternal recognition of pregnancy (MRP) in the mare is not well defined. In a non-pregnant mare, prostaglandin F2α (PGF) is released on day 14 post-ovulation (PO) to cause luteal regression, resulting in loss of progesterone production. Equine MRP occurs
Bouma, Gerrit J +10 more
core +1 more source
CRISPR-Cas9 off-targeting assessment with nucleic acid duplex energy parameters
Genome Biology, 2018 Background Recent experimental efforts of CRISPR-Cas9 systems have shown that off-target binding and cleavage are a concern for the system and that this is highly dependent on the selected guide RNA (gRNA) design. Computational predictions of off-targets
Ferhat Alkan +4 more
doaj +1 more source
Frontiers in Genetics, 2020 Recently, a few animals have been frequently reported to have been diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whether they are SARS-CoV-2 intermediate hosts is worthy of great attention.
Min Shen +11 more
doaj +1 more source
Flagella disruption in Bacillus subtilis increases amylase production yield
Microbial Cell Factories, 2022 Background Bacillus subtilis is a Gram-positive bacterium used as a cell factory for protein production. Over the last decades, the continued optimization of production strains has increased yields of enzymes, such as amylases, and made commercial ...
Annaleigh Ohrt Fehler +6 more
doaj +1 more source
Long non-coding RNA expression profiling in the NCI60 cancer cell line panel using high-throughput RT-qPCR [PDF]
, 2016 Long non-coding RNAs (lncRNAs) form a new class of RNA molecules implicated in various aspects of protein coding gene expression regulation. To study lncRNAs in cancer, we generated expression profiles for 1707 human lncRNAs in the NCI60 cancer cell line
Derveaux, Stefaan +5 more
core +2 more sources
Non-coding RNAs and retroviruses [PDF]
Retrovirology, 2018 Retroviruses can cause severe diseases such as cancer and acquired immunodeficiency syndrome. A unique feature in the life cycle of retroviruses is that their RNA genome is reverse transcribed into double-stranded DNA, which then integrates into the host genome to exploit the host machinery for their benefits.
Xu Zhang +4 more
openaire +3 more sources
Potential treatment with Chinese and Western medicine targeting NSP14 of SARS-CoV-2
Journal of Pharmaceutical Analysis, 2021 The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a serious global health threat.
Chao Liu +5 more
doaj +1 more source
Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome [PDF]
, 2012 Brain aging frequently underlies cognitive decline and is a major risk factor for neurodegenerative conditions. The exact molecular mechanisms underlying brain aging, however, remain unknown. Whole transcriptome sequencing provides unparalleled depth and
Brian Merry +4 more
core +1 more source