Results 41 to 50 of about 688,893 (310)

miR-144/451 in hematopoiesis and beyond [PDF]

ExRNA, 2019
MicroRNAs (miRNAs), a class of 18–25 nucleotide (nt) non-coding RNAs, usually inhibit the expression of their target genes. They are transcribed from endogenous genes and are processed for maturation by multiple pathways.
Ting Wang, Fan Wu, Duonan Yu
doaj   +1 more source

Resistance of Klebsiella pneumoniae to Phage hvKpP3 Due to High-Molecular Weight Lipopolysaccharide Synthesis Failure

Microbiology Spectrum, 2023
The spread of multidrug resistant and hypervirulent Klebsiella pneumoniae has recently increased. Phages have been considered alternatives for treating infections caused by tenacious pathogens.
Huaixin Geng, Lingjie Song, Xianggui Yang, Siyu Xing, Rui Wang, Ying Xu, Xu Jia, Guangxin Luan   +7 more
doaj   +1 more source

Non-Coding RNAs and Endometrial Cancer [PDF]

Genes, 2018
Non-coding RNAs (ncRNAs) are involved in the regulation of cell metabolism and neoplastic transformation. Recent studies have tried to clarify the significance of these information carriers in the genesis and progression of various cancers and their use as biomarkers for the disease; possible targets for the inhibition of growth and invasion by the ...
Vallone C., Rigon G., Gulia C., Baffa A., Votino R., Morosetti G., Zaami S., Briganti V., Catania F., Gaffi M., Nucciotti R., Costantini F. M., Piergentili R., Putignani L., Signore F.   +14 more
openaire   +3 more sources

Non‐coding RNAs: regulators of disease [PDF]

The Journal of Pathology, 2009
AbstractFor 50 years the term ‘gene’ has been synonymous with regions of the genome encoding mRNAs that are translated into protein. However, recent genome‐wide studies have shown that the human genome is pervasively transcribed and produces many thousands of regulatory non‐protein‐coding RNAs (ncRNAs), including microRNAs, small interfering RNAs, PIWI‐
Taft, R. J., Pang, K. C., Mercer, T. R., Dinger, M, Mattick, J. S.   +4 more
openaire   +5 more sources

The role of noncoding RNAs in cancer lipid metabolism

Frontiers in Oncology, 2022
Research on noncoding ribonucleic acids (ncRNAs) is mostly and broadly focused on microRNAs (miRNAs), cyclic RNAs (circRNAs), and long ncRNAs (lncRNAs), which have been confirmed to play important roles in tumor cell proliferation, invasion, and ...
Ye Wang, Ye Wang, Ye Wang, Qian Li, Qian Li, Qian Li, Song Wang, Song Wang, Song Wang, Bi-jun Wang, Yan Jin, Yan Jin, Yan Jin, Hao Hu, Hao Hu, Hao Hu, Qing-sheng Fu, Qing-sheng Fu, Qing-sheng Fu, Jia-wei Wang, Jia-wei Wang, Jia-wei Wang, Qing Wu, Qing Wu, Qing Wu, Long Qian, Long Qian, Long Qian, Ting-ting Cao, Ting-ting Cao, Ting-ting Cao, Ya-bin Xia, Ya-bin Xia, Ya-bin Xia, Xiao-xu Huang, Xiao-xu Huang, Xiao-xu Huang, Li Xu, Li Xu, Li Xu   +39 more
doaj   +1 more source

CRISPR-Cas9 off-targeting assessment with nucleic acid duplex energy parameters

Genome Biology, 2018
Background Recent experimental efforts of CRISPR-Cas9 systems have shown that off-target binding and cleavage are a concern for the system and that this is highly dependent on the selected guide RNA (gRNA) design. Computational predictions of off-targets
Ferhat Alkan, Anne Wenzel, Christian Anthon, Jakob Hull Havgaard, Jan Gorodkin   +4 more
doaj   +1 more source

Predicting the Animal Susceptibility and Therapeutic Drugs to SARS-CoV-2 Based on Spike Glycoprotein Combined With ACE2

Frontiers in Genetics, 2020
Recently, a few animals have been frequently reported to have been diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whether they are SARS-CoV-2 intermediate hosts is worthy of great attention.
Min Shen, Chao Liu, Run Xu, Zijing Ruan, Shiying Zhao, Huidong Zhang, Wen Wang, Xinhe Huang, Li Yang, Yong Tang, Tai Yang, Xu Jia   +11 more
doaj   +1 more source

The G3BP1-UPF1-Associated Long Non-Coding RNA CALA Regulates RNA Turnover in the Cytoplasm

, 2022
Besides transcription, RNA decay accounts for a large proportion of regulated gene expression and is paramount for cellular functions. Classical RNA surveillance pathways, like nonsense-mediated decay (NMD), are also implicated in the turnover of non ...
Jaé, Nicolas Christopher, Wittig, I., Andreas W. Heumüller, Knau, A., Youssef Fouani, Aslan, Galip S., Heumüller, Andreas W., Galip S. Aslan, Aslan, G., Dimmeler, S., Fouani, Youssef, Fouani, Y., Andrea Knau, Mueller-McNicoll, M., Michaela Müller-McNicoll, Müller-McNicoll, Michaela, Knau, Andrea, Jaé, Nicolas, Ilka Wittig, Heumüller, Andreas, Wittig, Ilka, Heumueller, A., Jae, N., Kirchhof, Luisa, Stefanie Dimmeler, Dimmeler, Stefanie, Nicolas Jaé, Kirchhof, L., Luisa Kirchhof   +28 more
core   +1 more source

Non-Coding RNAs in Endometrial Physiopathology [PDF]

International Journal of Molecular Sciences, 2018
The Human Genome Project led to the discovery that about 80% of our DNA is transcribed in RNA molecules. Only 2% of the human genome is translated into proteins, the rest mostly produces molecules called non-coding RNAs, which are a heterogeneous class of RNAs involved in different steps of gene regulation. They have been classified, according to their
La Ferlita, Alessandro, Battaglia, Rosalia, Andronico, Francesca, Caruso, Salvatore, Cianci, Antonio, Purrello, Michele, Di Pietro, Cinzia   +6 more
openaire   +2 more sources

Flagella disruption in Bacillus subtilis increases amylase production yield

Microbial Cell Factories, 2022
Background Bacillus subtilis is a Gram-positive bacterium used as a cell factory for protein production. Over the last decades, the continued optimization of production strains has increased yields of enzymes, such as amylases, and made commercial ...
Annaleigh Ohrt Fehler, Thomas Beuchert Kallehauge, Adrian Sven Geissler, Enrique González-Tortuero, Stefan Ernst Seemann, Jan Gorodkin, Jeppe Vinther   +6 more
doaj   +1 more source