Results 21 to 30 of about 11,605,954 (262)

Long Non-Coding RNA Signatures in Lymphopoiesis and Lymphoid Malignancies

, 2023
Lymphoid cells play a critical role in the immune system, which includes three subgroups of T, B, and NK cells. Recognition of the complexity of the human genetics transcriptome in lymphopoiesis has revolutionized our understanding of the regulatory ...
Mahdi Zavvar, Mahmoud Vahidi, Mojgan Mohammadimehr, Mahdi Ghorbani, Davood Bashash, Hamed Baghdadi, Mehdi Shakouri Khomartash, Nazanin Ahmadi, Reza Heidari   +8 more
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Crosstalk between Long Non-Coding RNA and Spliceosomal microRNA as a Novel Biomarker for Cancer

, 2023
Non-coding RNAs (ncRNAs) play diverse roles in regulating cellular processes and have been implicated in pathological conditions, including cancer, where interactions between ncRNAs play a role.
Maram Arafat, Ruth Sperling
core   +1 more source

Associating transcription factors and conserved RNA structures with gene regulation in the human brain

Scientific Reports, 2017
Anatomical subdivisions of the human brain can be associated with different neuronal functions. This functional diversification is reflected by differences in gene expression.
Nikolai Hecker, Stefan E. Seemann, Asli Silahtaroglu, Walter L. Ruzzo, Jan Gorodkin   +4 more
doaj   +1 more source

Resistance of Klebsiella pneumoniae to Phage hvKpP3 Due to High-Molecular Weight Lipopolysaccharide Synthesis Failure

Microbiology Spectrum, 2023
The spread of multidrug resistant and hypervirulent Klebsiella pneumoniae has recently increased. Phages have been considered alternatives for treating infections caused by tenacious pathogens.
Huaixin Geng, Lingjie Song, Xianggui Yang, Siyu Xing, Rui Wang, Ying Xu, Xu Jia, Guangxin Luan   +7 more
doaj   +1 more source

miR-144/451 in hematopoiesis and beyond [PDF]

ExRNA, 2019
MicroRNAs (miRNAs), a class of 18–25 nucleotide (nt) non-coding RNAs, usually inhibit the expression of their target genes. They are transcribed from endogenous genes and are processed for maturation by multiple pathways.
Ting Wang, Fan Wu, Duonan Yu
doaj   +1 more source

Non-Coding RNAs: Foes or Friends for Targeting Tumor Microenvironment [PDF]

, 2023
Non-coding RNAs (ncRNAs) are a group of molecules critical for cell development and growth regulation. They are key regulators of important cellular pathways in the tumor microenvironment.
Cristian Rodriguez-Aguayo, Anna Szymanowska, Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Gabriel Lopez-Berestein, Amero, Paola, Paola Amero, Szymanowska, Anna   +7 more
core   +1 more source

The role of noncoding RNAs in cancer lipid metabolism

Frontiers in Oncology, 2022
Research on noncoding ribonucleic acids (ncRNAs) is mostly and broadly focused on microRNAs (miRNAs), cyclic RNAs (circRNAs), and long ncRNAs (lncRNAs), which have been confirmed to play important roles in tumor cell proliferation, invasion, and ...
Ye Wang, Ye Wang, Ye Wang, Qian Li, Qian Li, Qian Li, Song Wang, Song Wang, Song Wang, Bi-jun Wang, Yan Jin, Yan Jin, Yan Jin, Hao Hu, Hao Hu, Hao Hu, Qing-sheng Fu, Qing-sheng Fu, Qing-sheng Fu, Jia-wei Wang, Jia-wei Wang, Jia-wei Wang, Qing Wu, Qing Wu, Qing Wu, Long Qian, Long Qian, Long Qian, Ting-ting Cao, Ting-ting Cao, Ting-ting Cao, Ya-bin Xia, Ya-bin Xia, Ya-bin Xia, Xiao-xu Huang, Xiao-xu Huang, Xiao-xu Huang, Li Xu, Li Xu, Li Xu   +39 more
doaj   +1 more source

CRISPR-Cas9 off-targeting assessment with nucleic acid duplex energy parameters

Genome Biology, 2018
Background Recent experimental efforts of CRISPR-Cas9 systems have shown that off-target binding and cleavage are a concern for the system and that this is highly dependent on the selected guide RNA (gRNA) design. Computational predictions of off-targets
Ferhat Alkan, Anne Wenzel, Christian Anthon, Jakob Hull Havgaard, Jan Gorodkin   +4 more
doaj   +1 more source

Predicting the Animal Susceptibility and Therapeutic Drugs to SARS-CoV-2 Based on Spike Glycoprotein Combined With ACE2

Frontiers in Genetics, 2020
Recently, a few animals have been frequently reported to have been diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whether they are SARS-CoV-2 intermediate hosts is worthy of great attention.
Min Shen, Chao Liu, Run Xu, Zijing Ruan, Shiying Zhao, Huidong Zhang, Wen Wang, Xinhe Huang, Li Yang, Yong Tang, Tai Yang, Xu Jia   +11 more
doaj   +1 more source

The G3BP1-UPF1-Associated Long Non-Coding RNA CALA Regulates RNA Turnover in the Cytoplasm

, 2022
Besides transcription, RNA decay accounts for a large proportion of regulated gene expression and is paramount for cellular functions. Classical RNA surveillance pathways, like nonsense-mediated decay (NMD), are also implicated in the turnover of non ...
Jaé, Nicolas Christopher, Wittig, I., Andreas W. Heumüller, Knau, A., Youssef Fouani, Aslan, Galip S., Heumüller, Andreas W., Galip S. Aslan, Aslan, G., Dimmeler, S., Fouani, Youssef, Fouani, Y., Andrea Knau, Mueller-McNicoll, M., Michaela Müller-McNicoll, Müller-McNicoll, Michaela, Knau, Andrea, Jaé, Nicolas, Ilka Wittig, Heumüller, Andreas, Wittig, Ilka, Heumueller, A., Jae, N., Kirchhof, Luisa, Stefanie Dimmeler, Dimmeler, Stefanie, Nicolas Jaé, Kirchhof, L., Luisa Kirchhof   +28 more
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