Results 11 to 20 of about 573,167 (219)

The antiviral activity of a small molecule drug targeting the NSP1-ribosome complex against Omicron, especially in elderly patients

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionWith the emergence of SARS-CoV-2 mutant strains, especially the epidemic of Omicron, it continues to evolve to strengthen immune evasion. Omicron BQ.
Min Shen, Min Shen, Ping Ding, Guangxin Luan, Ting Du, Shanshan Deng   +5 more
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The miR-28-5p Targetome Discovery Identified SREBF2 as One of the Mediators of the miR-28-5p Tumor Suppressor Activity in Prostate Cancer Cells

Cells, 2020
miR-28-5p is downregulated in some tumor tissues in which it has been demonstrated to have tumor suppressor (TS) activity. Here, we demonstrate that miR-28-5p acts as a TS in prostate cancer (PCa) cells affecting cell proliferation/survival, as well as ...
Sofia Fazio, Gabriele Berti, Francesco Russo, Monica Evangelista, Romina D’Aurizio, Alberto Mercatanti, Marco Pellegrini, Milena Rizzo   +7 more
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Acknowledgement to Reviewers of Non-Coding RNA in 2017

Non-Coding RNA, 2018
Peer review is an essential part in the publication process, ensuring that Non-Coding RNA maintains high quality standards for its published papers.[...]
Non-Coding RNA Editorial Office
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Identification and characterization of novel conserved RNA structures in Drosophila

BMC Genomics, 2018
Background Comparative genomics approaches have facilitated the discovery of many novel non-coding and structured RNAs (ncRNAs). The increasing availability of related genomes now makes it possible to systematically search for compensatory base changes –
Rebecca Kirsch, Stefan E. Seemann, Walter L. Ruzzo, Stephen M. Cohen, Peter F. Stadler, Jan Gorodkin   +5 more
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Combined VEGFR and MAPK pathway inhibition in angiosarcoma

Scientific Reports, 2021
Angiosarcoma is an aggressive malignancy of endothelial cells that carries a high mortality rate. Cytotoxic chemotherapy can elicit clinical responses, but the duration of response is limited.
Michael J. Wagner, Yasmin A. Lyons, Jean H. Siedel, Robert Dood, Archana S. Nagaraja, Monika Haemmerle, Lingegowda S. Mangala, Pritha Chanana, Alexander J. Lazar, Wei-Lien Wang, Vinod Ravi, Eric C. Holland, Anil K. Sood   +12 more
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Associating transcription factors and conserved RNA structures with gene regulation in the human brain

Scientific Reports, 2017
Anatomical subdivisions of the human brain can be associated with different neuronal functions. This functional diversification is reflected by differences in gene expression.
Nikolai Hecker, Stefan E. Seemann, Asli Silahtaroglu, Walter L. Ruzzo, Jan Gorodkin   +4 more
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Resistance of Klebsiella pneumoniae to Phage hvKpP3 Due to High-Molecular Weight Lipopolysaccharide Synthesis Failure

Microbiology Spectrum, 2023
The spread of multidrug resistant and hypervirulent Klebsiella pneumoniae has recently increased. Phages have been considered alternatives for treating infections caused by tenacious pathogens.
Huaixin Geng, Lingjie Song, Xianggui Yang, Siyu Xing, Rui Wang, Ying Xu, Xu Jia, Guangxin Luan   +7 more
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miR-144/451 in hematopoiesis and beyond [PDF]

ExRNA, 2019
MicroRNAs (miRNAs), a class of 18–25 nucleotide (nt) non-coding RNAs, usually inhibit the expression of their target genes. They are transcribed from endogenous genes and are processed for maturation by multiple pathways.
Ting Wang, Fan Wu, Duonan Yu
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The role of noncoding RNAs in cancer lipid metabolism

Frontiers in Oncology, 2022
Research on noncoding ribonucleic acids (ncRNAs) is mostly and broadly focused on microRNAs (miRNAs), cyclic RNAs (circRNAs), and long ncRNAs (lncRNAs), which have been confirmed to play important roles in tumor cell proliferation, invasion, and ...
Ye Wang, Ye Wang, Ye Wang, Qian Li, Qian Li, Qian Li, Song Wang, Song Wang, Song Wang, Bi-jun Wang, Yan Jin, Yan Jin, Yan Jin, Hao Hu, Hao Hu, Hao Hu, Qing-sheng Fu, Qing-sheng Fu, Qing-sheng Fu, Jia-wei Wang, Jia-wei Wang, Jia-wei Wang, Qing Wu, Qing Wu, Qing Wu, Long Qian, Long Qian, Long Qian, Ting-ting Cao, Ting-ting Cao, Ting-ting Cao, Ya-bin Xia, Ya-bin Xia, Ya-bin Xia, Xiao-xu Huang, Xiao-xu Huang, Xiao-xu Huang, Li Xu, Li Xu, Li Xu   +39 more
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CRISPR-Cas9 off-targeting assessment with nucleic acid duplex energy parameters

Genome Biology, 2018
Background Recent experimental efforts of CRISPR-Cas9 systems have shown that off-target binding and cleavage are a concern for the system and that this is highly dependent on the selected guide RNA (gRNA) design. Computational predictions of off-targets
Ferhat Alkan, Anne Wenzel, Christian Anthon, Jakob Hull Havgaard, Jan Gorodkin   +4 more
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