Results 41 to 50 of about 427,213 (218)

Vaccination coverage with the pneumococcal and influenza vaccine among persons with chronic diseases in Shanghai, China, 2017

BMC Public Health, 2020
Background Adults with chronic conditions such as heart disease, diabetes, or lung disease are more likely to develop complications from a number of vaccine-preventable diseases, including influenza and pneumonia.
Yuheng Wang, Minna Cheng, Siyuan Wang, Fei Wu, Qinghua Yan, Qinping Yang, Yanyun Li, Xiang Guo, Chen Fu, Yan Shi, Abram L. Wagner, Matthew L. Boulton   +11 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

The association between ambient air pollution and the risk of incident nasopharyngeal carcinoma in Hangzhou, China

Scientific Reports
Ambient air pollution exposure was associated with an increased risk of incident cancer, but few previous studies have focused on the associations between ambient air pollution and nasopharyngeal carcinoma (NPC).
Zesheng Chen, Zongxue Cheng, Yaoyao Wu, Zhecong Yu, Kang Qin, Caixia Jiang, Jue Xu   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Nighttime sleep duration and dual management of blood pressure and glycemia in Chinese with comorbid hypertension and diabetes

Scientific Reports
To characterize the associations between nighttime sleep duration and control of blood pressure (BP) and glycemia in individuals with comorbid hypertension and diabetes, we conducted a cross-sectional analysis of 2794 participants aged ≥ 50 years with ...
Binglin Chen, Haifeng Xu, Yan Shi, Minna Cheng, Jia Chen, Xuyan Su, Haiying Tang, Danying Pan, Qinghua Yan   +8 more
doaj   +1 more source

Associations of changes in waist circumference and BMI with variation of fasting blood glucose among middle aged and elderly residents at high cardiovascular risk: a follow-up study in Jiangsu province

Zhongguo gonggong weisheng
Objective To investigate associations of changes in waist circumference (WC) and body mass index (BMI) with the variation of fasting blood glucose among middle aged and elderly residents with high cardiovascular risk.
Xun WU, Yu QIN, Jian SU, Lulu CHEN, Lan CUI, Ran TAO, Jinyi ZHOU   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Effects of chronic diseases on health related quality of life is mediated by sleep difficulty in middle aged and older adults

Scientific Reports
Middle-aged and older adults with chronic diseases are more likely to encounter sleep difficulty and have a reduced Health-Related Quality of Life (HRQoL), but there is little research on their possible mechanisms.
Yaoyao Wu, Zesheng Chen, Zongxue Cheng, Zhecong Yu, Kang Qin, Caixia Jiang, Jue Xu   +6 more
doaj   +1 more source