Results 61 to 70 of about 1,704,490 (380)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Health needs of the Roma population in the Czech and Slovak Republics. [PDF]

, 2002
In the growing literature on the human rights of Roma people in Central Europe, their relatively poor health status is often mentioned. However, little concrete information exists about the contemporary health status of the Roma in this region. We sought
Epstein, H, Hajioff, S, Holcík, J, Koupilová, I, McKee, M   +4 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Comparison of novel and traditional anthropometric indices in Eastern-China adults: which is the best indicator of the metabolically obese normal weight phenotype?

BMC Public Health
Background People with the metabolically obese normal weight (MONW) phenotype have been confirmed to significantly increase the risk of unfavorable health consequences.
Yijia Chen, Chenchen Wang, Qiannan Sun, Qing Ye, Hairong Zhou, Zhenzhen Qin, Shengxiang Qi, Weiwei Wang, Xin Hong   +8 more
doaj   +1 more source

Analysis on the prevalence and temporal trends of adverse birth outcomes among neonates in Shanghai from 2010 to 2023

Frontiers in Public Health
BackgroundPrevious research has focused on the risk factors of adverse birth outcomes and its short-term and long-term consequences. However, study on the temporal trends of adverse birth outcomes is few.
Yongfa Qin, Jia Zhao, Yiyuan Li, Jing Chen, Yin Dai, Hui Li, Tao Zhang, Zhe Sun, Ying Lu, Xue Han   +9 more
doaj   +1 more source

Knowledge and History of Non Communicable Diseases Among Housewives in the Year 2013 Ogan Ilir-south Sumatera-Indonesia [PDF]

, 2015
Background: Indonesia as a developing country experiencing epidemiologic transition in which communicable diseases are still main concern in Indonesia, while non-communicable diseases (degenerative) is starting to increase and to be major cause of death.
Mutahar, R. (Rini), Najmah, N. (Najmah), Yeni, Y. (Yeni)   +2 more
core  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Research needs for an improved primary care response to chronic non-communicable diseases in Africa. [PDF]

, 2010
With non-communicable diseases (NCDs) projected to become leading causes of morbidity and mortality in developing countries, research is needed to improve the primary care response, especially in sub-Saharan Africa.
Abegunde, Adeyi, Anonymous, Bach, Beaglehole, Chan, Coovadia, Council for International Organisations of Medical Sciences, Craig, Daar, Harries, Harries, Kumwenda, Maher, Maher, Maher, Ministry of Health of Government of Uganda, Ministry of Health of Government of Uganda, Ooms, Sanders, Setel, Sewankambo, Suhrcke, Tollman, United Kingdom Department for International Development, WHO, WHO, WHO, Wilkinson, World Diabetes Foundation   +29 more
core   +1 more source

Cost and affordability of non-communicable disease screening, diagnosis and treatment in Kenya: Patient payments in the private and public sectors

PLoS ONE, 2018
Introduction The prevalence of non-communicable diseases (NCDs) is rising in low- and middle-income countries, including Kenya, disproportionately to the rest of the world. Our objective was to quantify patient payments to obtain NCD screening, diagnosis,
S. Subramanian, Robai Gakunga, J. Kibachio, G. Gathecha, Patrick Edwards, E. Ogola, G. Yonga, N. Busakhala, E. Munyoro, J. Chakaya, N. Ngugi, N. Mwangi, D. von Rège, L. Wangari, David Wata, Robert N Makori, Julius Mwangi, W. Mwanda   +17 more
semanticscholar   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source