Results 61 to 70 of about 152,213 (313)

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Association between physical activity energy expenditure and cardiometabolic risk factor clustering among Chinese adults in 2015

Sports Medicine and Health Science, 2022
To understand the association between cardiometabolic risk factor (CMRF) clustering and physical activity (PA) levels, we included 86520 Chinese adults aged 18–64 years having at least one CMRF (hypertension, diabetes, dyslipidemia, or obesity) from the ...
Xiaorong Chen, Mei Zhang, Limin Wang, Zhengjing Huang, Wenrong Zhang, Jing Wu   +5 more
doaj  

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

COVID-19 and renal involvement in children: a retrospective study

Caspian Journal of Internal Medicine, 2022
Background: The New coronavirus (SARS COV-2) can cause acute respiratory disease and also multiorgan dysfunction. There is insufficient data about kidney involvement in children. So, this study was done on children with COVID-19 to evaluate nephrological
Hadi Sorkhi, Mohamadreza esmaeilidooki, Maryam Nikpour, Mohsen Mohammadi, Ali Mohammadpour-Mir5, Masood Kiani, Sanaz Mehrabani, Sahar Sadr Moharerpour, Morteza Alijanpour, Kazem Babazadeh, Hassan Mahmoodi-Nesheli, Mohamadreza Tabatabaie, Ahmad Tamaddoni, Mohammadreza Salehiomran, Paiam Payandeh, Iraj Mohammadzadeh, Sareh Hosseinpour   +16 more
doaj  

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Analysis of core information awareness of chronic disease prevention and control and its influencing factors among adult residents in Heilongjiang province in 2021: an online survy

Zhongguo gonggong weisheng
ObjectiveTo understand the core information awareness of chronic disease prevention and control and its influencing factors among adult residents in Heilongjiang province, and to provide a reference for formulating chronic disease prevention and control ...
Yong ZHOU, Lei WANG, Lin JIN, Jiancheng ZHAO, Yangchun LI, Xiaoming CUI, Wei SUN, Shichun YAN   +7 more
doaj   +1 more source

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

Effect of TyG combined with obesity indicators on prevalence of hypertension and hyperuricemia comorbidity among residents aged 35 years and older in Hebei province: a surveillance data analysis

Zhongguo gonggong weisheng
ObjectiveTo investigate the effect of the triglyceride-glucose index (TyG) combined with various obesity indicators on the prevalence of comorbid hypertension and hyperuricemia among residents aged 35 years and older in Hebei province, and to provide a ...
Lijuan TANG, Yajing CAO, Jinchai GAO, Fujuan YUE, Yifu GAO, Fan ZHANG, Weiwei SHI, Dongsheng JIANG   +7 more
doaj   +1 more source

Earthing effects on mitochondrial function: ATP production and ROS generation

FEBS Open Bio, EarlyView.
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley   +1 more source