Results 61 to 70 of about 1,219,864 (340)

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Newly estimated disability weights for 196 health states in Hubei Province, China

Population Health Metrics
Background The disability weight (DW) reflects the severity of non-fatal outcomes and is an important parameter in calculating the burden of disease. However, the universality of the global, national, or subnational DWs remains controversial.
Mengge Zhou, Lan Zhang, Tianjing He, Shuzhen Zhu, Yumeng Tang, Qian Li, Miaoyan Shen, Jingju Pan   +7 more
doaj   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

The association between chronic kidney disease and tuberculosis; a comparative cohort study in England

BMC Nephrology, 2020
Background People with end-stage kidney disease have an increased risk of active tuberculosis (TB). Previous systematic reviews have demonstrated that patients with chronic kidney disease (CKD) have increased risk of severe community-acquired infections.
Judith Ruzangi, Masao Iwagami, Liam Smeeth, Punam Mangtani, Dorothea Nitsch   +4 more
doaj   +1 more source

DomainScope: A disease network based on protein domain connections [PDF]

arXiv, 2019
Protein domains are highly conserved functional units of proteins. Because they carry functionally significant information, the majority of the coding disease variants are located on domains. Additionally, domains are specific units of the proteins that can be targeted for drug delivery purposes.
arxiv  

First Africa non-communicable disease research conference 2017: sharing evidence and identifying research priorities

Journal of Global Health, 2019
Non-communicable diseases (NCDs) prevalence is rising fastest in lower income settings, and with more devastating outcomes compared to High Income Countries (HICs).
Kenneth Juma, Pamela A. Juma, S. Mohamed, J. Owuor, Agnes N Wanyoike, David Mulabi, George Odinya, Maureen Njeru, G. Yonga   +8 more
semanticscholar   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

The association between ambient air pollution and the risk of incident nasopharyngeal carcinoma in Hangzhou, China

Scientific Reports
Ambient air pollution exposure was associated with an increased risk of incident cancer, but few previous studies have focused on the associations between ambient air pollution and nasopharyngeal carcinoma (NPC).
Zesheng Chen, Zongxue Cheng, Yaoyao Wu, Zhecong Yu, Kang Qin, Caixia Jiang, Jue Xu   +6 more
doaj   +1 more source

Associations of changes in waist circumference and BMI with variation of fasting blood glucose among middle aged and elderly residents at high cardiovascular risk: a follow-up study in Jiangsu province

Zhongguo gonggong weisheng
Objective To investigate associations of changes in waist circumference (WC) and body mass index (BMI) with the variation of fasting blood glucose among middle aged and elderly residents with high cardiovascular risk.
Xun WU, Yu QIN, Jian SU, Lulu CHEN, Lan CUI, Ran TAO, Jinyi ZHOU   +6 more
doaj   +1 more source

Non-communicable disease prevention policy process in five African countries authors

BMC Public Health, 2018
BackgroundThe increasing burden of non-communicable diseases (NCDs) in sub-Saharan Africa is causing further burden to the health care systems that are least equipped to deal with the challenge. Countries are developing policies to address major NCD risk
Pamela A. Juma, S. Mohamed, Beatrice L. Matanje Mwagomba, C. Ndinda, Clarisse Mapa-Tassou, M. Oluwasanu, O. Oladepo, O. Abiona, M. Nkhata, J. Wisdom, J. Mbanya   +10 more
semanticscholar   +1 more source