Results 41 to 50 of about 422,178 (239)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Predictors of sleep quality subscales among medical university employees in Iran: a Bayesian analysis of cross-sectional data

BMC Public Health
Background Poor sleep quality is prevalent among medical employees and adversely affects their performance and well-being. Limited evidence exists regarding behavioral, psychological, and health-related risk factors for poor sleep quality in medical ...
Zahra Hosseinkhani, Edris Kakemam, Maryam Hadji, Neda Mohammadi   +3 more
doaj   +1 more source

The burden of chronic respiratory disease and attributable risk factors in North Africa and Middle East: findings from global burden of disease study (GBD) 2019

Respiratory Research, 2022
Background North Africa and Middle East (NAME) has an increasing burden of chronic respiratory diseases (CRDs); however, a systematic understanding of the distribution and trends is not available.
Aida Fallahzadeh, Yeganeh Sharifnejad Tehrani, Ali Sheikhy, Seyyed-Hadi Ghamari, Esmaeil Mohammadi, Sahar Saeedi Moghaddam, Zahra Esfahani, Maryam Nasserinejad, Parnian Shobeiri, Mohammad-Mahdi Rashidi, Nazila Rezaei, Mahsa Heidari-Foroozan, Negar Rezaei, Bagher Larijani, Farshad Farzadfar   +14 more
doaj   +1 more source

Vaccines against non-communicable diseases

Current Opinion in Immunology, 2010
Chronic non-communicable diseases (NCDs) are increasingly recognized as the major cause of morbidity and mortality worldwide. Effective, affordable and broadly accessible medicines for their treatment are much sought after. Therapeutic B-cell vaccines aim at inducing neutralizing auto-reactive antibodies against important mediators of such diseases ...
Röhn, T, Bachmann, M
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The impact of good governance on organizational health with the mediating role of organizational accountability: considering the influence of demographic and organizational variables

BMC Health Services Research
Background Human resources are the critical element of organizations and serve as the economic engine of countries. Human resources play a crucial role in gaining competitive advantage.
Taiebeh Taheri, Mohammad Amerzadeh, Ahad Alizadeh, Rohollah Kalhor   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Predictors of Active Aging Among Community-dwelling Older Adults in Qazvin City, Iran, 2023 [PDF]

Iranian Rehabilitation Journal
Objectives: This study aims to determine the predictive factors of active aging among older people in Qazvin City, Iran. Methods: This study, conducted in 2023, included individuals aged >60 years in Qazvin City.
Zahra Shirshekan, Ahad Alizadeh, Mohammad Amerzadeh, Fatemeh Mohammadi, Seyedeh Ameneh Motalebi   +4 more
doaj  

Youth Manifesto on Non-Communicable Diseases

Global Heart, 2011
Sandeep P. Kishore , Karen R. Siegel , Aria Ahmad , Amina A. Aitsi-Selmi k, Mohammed K. Ali , Phillip Baker , Sanjay Basu , Asaf Bitton , Gerald S. Bloomfield , Gene Bukhman , Eleanor Emery , Andrea B. Feigl , Karen Grepin , Mark D. Huffman , Kiti Kajana , Shweta Khandelwal , Kavitha Kolappa , Chenhui Liu , Naaznin Lokhandwala , Vishal Marwah kk, Modi ...
Kishore, Sandeep P., Siegel, Karen R., Ahmad, Aria, Aitsi-Selmi, Amina A., Ali, Mohammed K., Baker, Phillip, Basu, Sanjay, Bitton, Asaf, Bloomfield, Gerald S., Bukhman, Gene, Emery, Eleanor, Feigl, Andrea B., Grepin, Karen, Huffman, Mark D., Kajana, Kiti, Khandelwal, Shweta, Kolappa, Kavitha, Liu, Chenhui, Lokhandwala, Naaznin, Marwah, Vishal, Mwatsama, Modi, Novak, Nicole, Nundy, Shantanu, Park, Paul H., Perez, Cristina Parsons, Price, Matthew R., Rapkin, Nikka, Rice, Hester, Seligman, Ben, Shah, Sumit, Silva, Joao da, Sridhar, Devi, Stuckler, David, Vedanthan, Rajesh, Zaman, Justin, Chronic Disease Network, The Young Professionals’   +35 more
openaire   +5 more sources