Results 51 to 60 of about 442,954 (307)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Prevalence of plasma lipid abnormalities and associated risk factors among Iranian adults based on the findings from STEPs survey 2021

Scientific Reports, 2023
The study aimed to estimate the prevalence of lipid abnormalities in Iranian adults by demographic characterization, geographical distribution, and associated risk factors using national and sub-national representative samples of the STEPs 2021 survey in
Javad Khanali, Erfan Ghasemi, Mohammad-Mahdi Rashidi, Naser Ahmadi, Seyyed-Hadi Ghamari, Mohammadreza Azangou-Khyavy, Mohammad-Reza Malekpour, Mohsen Abbasi-Kangevari, Seyedeh Melika Hashemi, Mohammadreza Naderian, Negar Rezaei, Arezou Dilmaghani-Marand, Yosef Farzi, Ameneh Kazemi, Moein Yoosefi, Amirali Hajebi, Shahabeddin Rezaei, Sina Azadnajafabad, Nima Fattahi, Maryam Nasserinejad, Elham Abdolhamidi, Rosa Haghshenas, Nazila Rezaei, Shirin Djalalinia, Bagher Larijani, Farshad Farzadfar   +25 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Predictors of sleep quality subscales among medical university employees in Iran: a Bayesian analysis of cross-sectional data

BMC Public Health
Background Poor sleep quality is prevalent among medical employees and adversely affects their performance and well-being. Limited evidence exists regarding behavioral, psychological, and health-related risk factors for poor sleep quality in medical ...
Zahra Hosseinkhani, Edris Kakemam, Maryam Hadji, Neda Mohammadi   +3 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

The impact of good governance on organizational health with the mediating role of organizational accountability: considering the influence of demographic and organizational variables

BMC Health Services Research
Background Human resources are the critical element of organizations and serve as the economic engine of countries. Human resources play a crucial role in gaining competitive advantage.
Taiebeh Taheri, Mohammad Amerzadeh, Ahad Alizadeh, Rohollah Kalhor   +3 more
doaj   +1 more source

Burden of stroke in North Africa and Middle East, 1990 to 2019: a systematic analysis for the global burden of disease study 2019

BMC Neurology, 2022
Background While several studies investigated the epidemiology and burden of stroke in the North Africa and Middle East region, no study has comprehensively evaluated the age-standardized attributable burden to all stroke subtypes and their risk factors ...
Ataollah Shahbandi, Parnian Shobeiri, Sina Azadnajafabad, Sahar Saeedi Moghaddam, Yeganeh Sharifnejad Tehrani, Narges Ebrahimi, Nazila Rezaei, Mohammad-Mahdi Rashidi, Seyyed-Hadi Ghamari, Mohsen Abbasi-Kangevari, Sogol Koolaji, Rosa Haghshenas, Negar Rezaei, Bagher Larijani, Farshad Farzadfar   +14 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Spatiotemporal Study of COVID-19 in Fars Province, Iran, October-November 2020: Establishment of Early Warning System

Canadian Journal of Infectious Diseases and Medical Microbiology, 2022
Background. Using time series and spatiotemporal analyses, this study aimed to establish an Early Warning System (EWS) for COVID-19 in Fars province Iran. Methods.
Ali Semati, Azimeh Zare, Marjan Zare, Alireza Mirahmadizadeh, Mostafa Ebrahimi   +4 more
doaj   +1 more source