Results 41 to 50 of about 451,593 (259)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Non-communicable diseases in southeast Asia [PDF]

The Lancet, 2011
According to Antonio Dans,1 lack of workforce and infrastructure is one of the limitations to management of non-communicable diseases (NCDs) in southeast Asia. We agree that the health-care delivery system was designed mainly to manage acute infectious diseases in resource-limited southeast Asian countries.
Poudel, Krishna C., Fujita, Masami, Green, Kimberly, Poudel-Tandukar, Kalpana, Jimba, Masamine   +4 more
openaire   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Predictors of sleep quality subscales among medical university employees in Iran: a Bayesian analysis of cross-sectional data

BMC Public Health
Background Poor sleep quality is prevalent among medical employees and adversely affects their performance and well-being. Limited evidence exists regarding behavioral, psychological, and health-related risk factors for poor sleep quality in medical ...
Zahra Hosseinkhani, Edris Kakemam, Maryam Hadji, Neda Mohammadi   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The impact of good governance on organizational health with the mediating role of organizational accountability: considering the influence of demographic and organizational variables

BMC Health Services Research
Background Human resources are the critical element of organizations and serve as the economic engine of countries. Human resources play a crucial role in gaining competitive advantage.
Taiebeh Taheri, Mohammad Amerzadeh, Ahad Alizadeh, Rohollah Kalhor   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Prevalence of plasma lipid abnormalities and associated risk factors among Iranian adults based on the findings from STEPs survey 2021

Scientific Reports, 2023
The study aimed to estimate the prevalence of lipid abnormalities in Iranian adults by demographic characterization, geographical distribution, and associated risk factors using national and sub-national representative samples of the STEPs 2021 survey in
Javad Khanali, Erfan Ghasemi, Mohammad-Mahdi Rashidi, Naser Ahmadi, Seyyed-Hadi Ghamari, Mohammadreza Azangou-Khyavy, Mohammad-Reza Malekpour, Mohsen Abbasi-Kangevari, Seyedeh Melika Hashemi, Mohammadreza Naderian, Negar Rezaei, Arezou Dilmaghani-Marand, Yosef Farzi, Ameneh Kazemi, Moein Yoosefi, Amirali Hajebi, Shahabeddin Rezaei, Sina Azadnajafabad, Nima Fattahi, Maryam Nasserinejad, Elham Abdolhamidi, Rosa Haghshenas, Nazila Rezaei, Shirin Djalalinia, Bagher Larijani, Farshad Farzadfar   +25 more
doaj   +1 more source

Remembering the forgotten non-communicable diseases [PDF]

BMC Medicine, 2014
The forthcoming post-Millennium Development Goals era will bring about new challenges in global health. Low- and middle-income countries will have to contend with a dual burden of infectious and non-communicable diseases (NCDs). Some of these NCDs, such as neoplasms, COPD, cardiovascular diseases and diabetes, cause much health loss worldwide and are ...
Lopez, AD, Williams, TN, Levin, A, Tonelli, M, Singh, JA, Burney, PGJ, Rehm, J, Volkow, ND, Koob, G, Ferri, CP   +9 more
openaire   +3 more sources