Results 81 to 90 of about 435,138 (258)

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Comparison of oral and intra venous midazolam for sedation in children undergoing upper gastrointestinal endoscopy

Caspian Journal of Pediatrics, 2015
Background: Selecting the best medication for upper GI endoscopy in children is a challenging issue. The goal of this study was to compare the effects of oral and intravenous midazolam for upper gastrointestinal endoscopy (UGIE) on children. Methods: In
Mohammadreza Esmaeilidooki, Sanaz Mehrabani, Ozra Molai, Manuchehr Askari, Mahsa Ghajarzadeh, Ali Bijani   +5 more
doaj  

Barriers and facilitators for high-risk pregnancy care: a qualitative study on the perspective of pregnant women of rural Rajasthan

Reproductive Health
Background High-risk pregnancies, which pose serious risks to the mother and fetus, remain a major global challenge, and the burden is intensified in India due to socio-economic disparities and inadequate healthcare infrastructure.
Mukti Khetan, Rakhi Dhankhar, Sakshi Verma, Simran Arora, Ramesh Kumar Sangwan, Ramesh Kumar Huda, Ashok Chaudhary, Bontha V. Babu   +7 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Evaluation of the first day transcutaneous bilirubin (TcB) level as a predictor of hyperbilirubinemia in healthy term neonates

Caspian Journal of Pediatrics, 2015
Background: The readmission rate for neonatal jaundice has been increased in recent years. This has been attributed to shorter length of postpartum hospital stays without comprehensive follow-up.
Yadollah Zahed Pasha, Mousa Ahmadpour-Kacho, Abdollah Dehvari, Ali Bijani, Tahereh Jahangir, Mehrangiz Baleghi   +5 more
doaj  

Differences in red blood cell fatty acid profiles by type 2 diabetes status in early-stage chronic kidney disease

Scientific Reports
Background Red blood cell (RBC) membrane fatty acid composition may reflect early metabolic disturbances linked to chronic kidney disease (CKD) and type 2 diabetes (T2D), offering insights into shared pathophysiological mechanisms.
Cindy George, Jillian Hill, N. Unati Nqebelele, Dipuo D. Motshwari, Nasheeta Peer, Andre P. Kengne, Paul J. van Jaarsveld   +6 more
doaj   +1 more source

Estimation of disease burden and multi-dimensional risk factors of chronic respiratory diseases among the residents near sandstone quarries in Jodhpur

Frontiers in Public Health
BackgroundAir pollution at mining sites is a global phenomenon; residents living around the sandstone quarries are at risk of CRDs. This is an initial research study to analyze the prevalence of CRDs, and the association of household environmental ...
Suresh Yadav, Pranali A. Ahir, Dinesh S. Bhati, Rajnish Gupta   +3 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source