Results 81 to 90 of about 451,593 (259)

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Comparison of oral and intra venous midazolam for sedation in children undergoing upper gastrointestinal endoscopy

Caspian Journal of Pediatrics, 2015
Background: Selecting the best medication for upper GI endoscopy in children is a challenging issue. The goal of this study was to compare the effects of oral and intravenous midazolam for upper gastrointestinal endoscopy (UGIE) on children. Methods: In
Mohammadreza Esmaeilidooki, Sanaz Mehrabani, Ozra Molai, Manuchehr Askari, Mahsa Ghajarzadeh, Ali Bijani   +5 more
doaj  

The relationship between health literacy and perceived social support with self-care behaviors in patients with heart failure

Discover Public Health
Background Health literacy (HL) and perceived social support (PSS) are two independent variables associated with self-care behaviors (SCB) among patients with heart failure (HF). The study aimed to detemine the relationship between HL and PSS with SCB in
Abdolmahdi Heidari, Sima Rafiei, Rohollah Kalhor, Mohammad Amerzadeh   +3 more
doaj   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Barriers and facilitators for high-risk pregnancy care: a qualitative study on the perspective of pregnant women of rural Rajasthan

Reproductive Health
Background High-risk pregnancies, which pose serious risks to the mother and fetus, remain a major global challenge, and the burden is intensified in India due to socio-economic disparities and inadequate healthcare infrastructure.
Mukti Khetan, Rakhi Dhankhar, Sakshi Verma, Simran Arora, Ramesh Kumar Sangwan, Ramesh Kumar Huda, Ashok Chaudhary, Bontha V. Babu   +7 more
doaj   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Evaluation of the first day transcutaneous bilirubin (TcB) level as a predictor of hyperbilirubinemia in healthy term neonates

Caspian Journal of Pediatrics, 2015
Background: The readmission rate for neonatal jaundice has been increased in recent years. This has been attributed to shorter length of postpartum hospital stays without comprehensive follow-up.
Yadollah Zahed Pasha, Mousa Ahmadpour-Kacho, Abdollah Dehvari, Ali Bijani, Tahereh Jahangir, Mehrangiz Baleghi   +5 more
doaj  

Estimation of disease burden and multi-dimensional risk factors of chronic respiratory diseases among the residents near sandstone quarries in Jodhpur

Frontiers in Public Health
BackgroundAir pollution at mining sites is a global phenomenon; residents living around the sandstone quarries are at risk of CRDs. This is an initial research study to analyze the prevalence of CRDs, and the association of household environmental ...
Suresh Yadav, Pranali A. Ahir, Dinesh S. Bhati, Rajnish Gupta   +3 more
doaj   +1 more source

Paramagnetic Rim Lesions and Choroid Plexus Volume at Diagnosis Are Associated With Cognitive Progression Independent of Relapse and MRI Activity in Early Relapsing–Remitting Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) and choroid plexus (CP) enlargement reflect smoldering inflammation in multiple sclerosis. Their role in cognitive progression remains unexplored. Eighty‐seven early relapsing–remitting MS patients were enrolled at diagnosis and followed longitudinally.
Stefano Ziccardi, Damiano Marastoni, Agnese Tamanti, Pietro Biasi, Valentina Visani, Annalisa Colombi, Tom A. Fuchs, Monica Sicchieri, Chiara Eccher, Francesco Guarnaccia, Milena Calderone, Valentina Camera, Francesca Benedetta Pizzini, Roberta Magliozzi, Marco Castellaro, Massimiliano Calabrese   +15 more
wiley   +1 more source

Differences in red blood cell fatty acid profiles by type 2 diabetes status in early-stage chronic kidney disease

Scientific Reports
Background Red blood cell (RBC) membrane fatty acid composition may reflect early metabolic disturbances linked to chronic kidney disease (CKD) and type 2 diabetes (T2D), offering insights into shared pathophysiological mechanisms.
Cindy George, Jillian Hill, N. Unati Nqebelele, Dipuo D. Motshwari, Nasheeta Peer, Andre P. Kengne, Paul J. van Jaarsveld   +6 more
doaj   +1 more source