Results 51 to 60 of about 639,340 (301)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Rayleigh-Benard Convection in Large-Aspect-Ratio Domains

, 2004
The coarsening and wavenumber selection of striped states growing from random initial conditions are studied in a non-relaxational, spatially extended, and far-from-equilibrium system by performing large-scale numerical simulations of Rayleigh-B\'{e}nard
I. Catton, K-H. Chiam, M. C. Cross, M. R. Paul, P. F. Fischer, Y. Pomeau   +5 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

SPHERIOUSLY? The challenges of estimating sphere radius non-invasively in the human brain from diffusion MRI

NeuroImage, 2021
The Soma and Neurite Density Imaging (SANDI) three-compartment model was recently proposed to disentangle cylindrical and spherical geometries, attributed to neurite and soma compartments, respectively, in brain tissue.
Maryam Afzali, Markus Nilsson, Marco Palombo, Derek K Jones   +3 more
doaj   +1 more source

Multi-domain Boundary Element Method in Nonlinear Liquid Sloshing Analysis for Fuel Tanks [PDF]

, 2016
The boundary element method is used for analysis of the non-linear sloshing response of liquid in cylindrical baffled and un-baffled fuel tanks. The liquid is supposed to be an ideal and incompressible one and its flow introduced by the vibrations of a
Gnitko, Vasyl I., Naumemko, Vitaly V., Strelnikova, Elena A.   +2 more
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

A Boundary Value Problem for a Time-Fractional Diffusion Equationin a Non-Cylindrical Shrinking Domain

Қарағанды университетінің хабаршысы. Математика сериясы
This article deals with the fundamental problems in the mathematical theory of fractional differential equations, specifically focusing on the analytical solvability of boundary value problems in time-dependent domains.
A.D. Akhmetshin, M.T. Omarov, R.Z. Toleukhanova   +2 more
doaj   +1 more source

Phase diagram for diblock copolymer melts under cylindrical confinement

, 2005
We extensively study the phase diagram of a diblock copolymer melt confined in a cylindrical nanopore using real-space self-consistent mean-field theory.
Cheng J. Y., Drolet F., Fredrickson G. H., Geisinger T., He X., Helfand E., Hong K. M., Huinink H. P., Matsen M. W., Matsen M. W., Morkved T. L., Park C., Park M., Press W. H., Rasmussen K., Segalman R. A., Sevink G. J. A., Shin K., Sun Y., Tzeremes G., We, Wickham R. A., Wu Y., Xiang H., Xiang H.   +24 more
core   +1 more source

Dynamics for the complex Ginzburg-Landau equation on non-cylindrical domains I: The diffeomorphism case

, 2016
The purpose of this article is to analyze the dynamics of the following complex Ginzburg-Landau equation \begin{align*} \partial_{t}u-(\lambda+i\alpha)\Delta u+(\kappa+i\beta)|u|^{p-2}u-\gamma u=f(t) \end{align*} on non-cylindrical domains, which are
F. Zhou, Chunyou Sun
semanticscholar   +1 more source

On a Problem Connected with Navier-stokes Equations in Non Cylindrical Domains

Journal of Mathematics and Statistics, 2005
Summary: We showed the existence of weak solutions of equations that represent flows of a non-homogeneous viscous incompressible fluids in a non cylindrical domain in \(\mathbb R^3\). The classical Navier-Stokes equation is a particular case of the equations here considered.
Limaco, J., De Menezes, S. B., Vaz, C., Montenegro, J. F   +3 more
openaire   +2 more sources