Results 41 to 50 of about 562,651 (301)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Comparative Study of Destructive Method and Non-destructive with Ultra-Sonic Pulse Velocity Method [PDF]

E3S Web of Conferences
The appropriate percentages of cement, fine aggregates, coarse aggregates, and water are utilized to make concrete. Due to its relatively low price and widespread availability, it is a ubiquitous building material. Concrete in its fresh state can also be
Katare Shivam, Kundil Abhilash Pideka, Helena Raj Vijilius, Arora Deepika, Gupta Manish, Alhussainy Ali K., Reddy M. Venkateswar   +6 more
doaj   +1 more source

Detectors for the James Webb Space Telescope Near-Infrared Spectrograph I: Readout Mode, Noise Model, and Calibration Considerations

, 2007
We describe how the James Webb Space Telescope (JWST) Near-Infrared Spectrograph's (NIRSpec's) detectors will be read out, and present a model of how noise scales with the number of multiple non-destructive reads sampling-up-the-ramp.
Augustyn Waczynski, Bacon C. M., Bernard J. Rauscher, Brent Mott, Bryan Howe, Cheryl Marshall, Chuck Engler, Clifford K. Brambora, Craig Cabelli, David Alexander, Donald N. B. Hall, Donna Wilson, Edward Cheng, Gardner J. P., Ginn Lee, Guido De Marchi, James Garnett, James York, James M. Marsh, Janesick J. R., John Nieznanski, Kamdin B. Shakoorzadeh, Klaus W. Hodapp, Majid Zandian, Markus Loose, Matthew B. Garrison, Michael W. Regan, Miles Smith, Miriam Jurado, Ori Fox, Paolo Strada, Peter Jakobsen, Peter Wallis, Pierre Ferruit, Rebecca Derro, Robert J. Hill, Robert J. Martineau, Selmer Wong‐Anglin, Sridhar S. Manthripragada, Thomas Johnson, Timothy Ellis, Torsten Böker, Wayne D. Roher, Wei Xia‐Serafino, Yiting Wen   +44 more
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Magnetic Barkhausen Noise Measurements on Rocks

Tecnura, 2022
Context: The magnetic properties of rocks may reflect the modal abundance, composition, and microstructure of the magnetic grains contained within them, usually in a very small proportion.
Miriam Rocío Neyra Astudillo, María Isabel López-Pumarega, Silvana Evangelina-Geuna, Martin Gómez   +3 more
doaj   +1 more source

Failure analysis of a steel motorcycle kickstand [PDF]

, 2009
Copyright @ 2009 Springer US.A fractured steel motorcycle kickstand was metallurgically investigated using a range of failure analysis tools [visual examination, energy dispersive X-ray (EDX) analysis, electron microprobe analysis (EPMA), scanning ...
A Sandvik, D Moulin, Koh Wen Shi, KR Jayadevan, MA Bahi, MJ Kabir, Robert Bulpett, V Abouei, VJ Colangelo, X Zhang, Zainul Huda   +10 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Determination of Mechanical Properties of Concrete by Destructive and Non-Destructive Experimental Methods [PDF]

, 2013
This paper examines the mechanical quality differences of concrete by destructive and non destructive methods according to shape, dimension relationship and cure conditions.
T. U. Ulusoy, Y. Yazicioglu
core  

High-Q Nanomechanics via Destructive Interference of Elastic Waves

, 2010
Mechanical dissipation poses an ubiquitous challenge to the performance of nanomechanical devices. Here we analyze the support-induced dissipation of high-stress nanomechanical resonators. We develop a model for this loss mechanism and test it on silicon
Barton, R. A., Craighead, H. G., Ilic, B., Parpia, J. M., Southworth, D. R., Verbridge, S. S., Wilson-Rae, I.   +6 more
core   +1 more source