Results 41 to 50 of about 672,639 (303)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Comparative Study of Destructive Method and Non-destructive with Ultra-Sonic Pulse Velocity Method [PDF]

E3S Web of Conferences
The appropriate percentages of cement, fine aggregates, coarse aggregates, and water are utilized to make concrete. Due to its relatively low price and widespread availability, it is a ubiquitous building material. Concrete in its fresh state can also be
Katare Shivam, Kundil Abhilash Pideka, Helena Raj Vijilius, Arora Deepika, Gupta Manish, Alhussainy Ali K., Reddy M. Venkateswar   +6 more
doaj   +1 more source

Magnetic Barkhausen Noise Measurements on Rocks

Tecnura, 2022
Context: The magnetic properties of rocks may reflect the modal abundance, composition, and microstructure of the magnetic grains contained within them, usually in a very small proportion.
Miriam Rocío Neyra Astudillo, María Isabel López-Pumarega, Silvana Evangelina-Geuna, Martin Gómez   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Korelasi Nilai Kuat Tekan Betondengan Menggunakan Non-Destructive Test dan Destructive Test. [PDF]

, 2018
pengujian yang digunakan untuk mengetahui kekuatan tekan beton pada umumnya dapat dibedakan menjadi tiga bagian yaitu metode dengan cara tidak merusak (non destructive test), setengah merusak (semi destructive test) dan merusak keseluruhan komponen ...
Wirotama, I Nengah Gandi
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Application of non destructive testing to the detection of aeronautical defects in composite structures [PDF]

, 2013
A study of two Non-destructive Testing methods (NDT) was carried out in specimens with different kinds of simulated defects. Ultrasonics test (US) and Infrared Thermography (IRT) were applied with the aim to evaluate the detectability and the accuracy of
Munoz Cuartas, Victor, Karama, Moussa, Welemane, Hélène, Welemane, H., Pastor, Marie-Laetitia, Munoz, Victor, Perrin, Marianne, Cantarel, Arthur, Munoz, V., Karama, M.   +9 more
core  

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source