Results 141 to 150 of about 157,420 (243)

Lactate‐Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis

Cell Proliferation, EarlyView.
This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo, Xiaoya Zhang, Danmei Zhang, Chunxia Shi, Luwen Wang, Zuojiong Gong   +5 more
wiley   +1 more source

Understanding molecular mechanisms of non-enveloped virus entry and disassembly [PDF]

Acta Crystallographica Section A Foundations and Advances, 2017
Manidipa Banerjee, Kimi Azad, Saumya Bajaj, Mohit Kumar, Debajit Dey   +4 more
openaire   +1 more source

Renal function in African women receiving tenofovir disoproxil fumarate as pre‐exposure prophylaxis for HIV during pregnancy and postpartum: A postpartum safety analysis in the CAP016 randomized control trial

HIV Medicine, EarlyView.
Abstract Background The effect of tenofovir disoproxil fumarate (TDF) when used as pre‐exposure prophylaxis (PrEP) on renal function in pregnant and postpartum women is understudied. An open‐label clinical trial (CAP016 study) was designed to examine the safety of TDF‐PrEP use during pregnancy and breastfeeding.
Gaysheen Kistan, Tonya Esterhuizen, Megeshinee Naidoo, Alicia C. Desmond, Motshedisi Sebitloane, Dhayendre Moodley   +5 more
wiley   +1 more source

Nanomolar concentrations of the photodynamic compound TLD-1433 effectively inactivate numerous human pathogenic viruses

Heliyon
The anti-viral properties of a small (≈1 kDa), novel Ru(II) photo dynamic compound (PDC), referred to as TLD-1433 (Ruvidar™), are presented. TLD-1433 had previously been demonstrated to exert strong anti-bacterial and anti-cancer properties. We evaluated
Kevin M. Coombs, Kathleen K.M. Glover, Raquel Russell, Pavel Kaspler, Mark Roufaiel, Drayson Graves, Peter Pelka, Darwyn Kobasa, Roger DuMoulin-White, Arkady Mandel   +9 more
doaj   +1 more source

Inducing Antigen‐Specific and Functional Immune Responses in Mice Toward Bovine Herpesvirus 1 and Bovine Respiratory Syncytial Virus by Chimeric Peptides Delivered by Bovine Herpesvirus 4‐Based Vector

Immunology, EarlyView.
Bovine Alphaherpesvirus 1 (BoHV‐1) and Bovine respiratory syncytial virus (BRSV) are major drivers of respiratory disease in cattle. (A) To target both pathogens, two chimeric antigens—membrane‐linked and secreted—combining BoHV‐1 glycoprotein D and BRSV fusion glycoprotein were designed and expressed using recombinant BoHV‐4‐based vectors.
Antonino Di Lorenzo, Sergio Minesso, Chiara Cossu, Valentina Franceschi, Elisabetta Bolli, Vittorio Madia, Laura Conti, Gaetano Donofrio   +7 more
wiley   +1 more source

Inactivation of Aerosolized Hepatitis A Viral Droplets on Food Contact Surfaces by Ultraviolet-Light-Emitting Diodes at 255 nm and 279 nm

Foods
Hepatitis A viral outbreaks continue to occur. It can be transmitted through aerosolized droplets and thus can contaminate surfaces and the environment.
Breanna Polen, Ankit Patras, Brahmaiah Pendyala, Doris H. D’Souza   +3 more
doaj   +1 more source

Fish Poxviruses on the Rise: Prospects for Aquatic Health

Journal of Fish Diseases, EarlyView.
ABSTRACT Fish poxviruses are increasingly recognised as emerging pathogens of fish and should be considered in cases of unexplained gill or skin pathology. Carp edema virus (CEV), the causative agent of koi sleepy disease in common carp and koi (Cyprinus carpio), represents the first known example.
Mikolaj Adamek, Marek Matras, Oluwaseun Christianah Ojelade, Motohiko Sano, Mona C. Gjessing, Tomas Korytar, Alberto Falco, Krzysztof Rakus, Verena Jung‐Schroers, Andor Doszpoly   +9 more
wiley   +1 more source

Melanoma and Other Melanistic Lesions in Brown Bullhead Ameiurus nebulosus From Waterbodies in the Northeastern United States and Canada: Identification of Risk Factors

Journal of Fish Diseases, EarlyView.
ABSTRACT Melanistic lesions, including non‐raised black areas due to proliferations of melanocytes and melanomacrophages in the dermis and epidermis, as well as raised black areas consistent with melanoma, are described in brown bullhead (BBH) Ameiurus nebulosus from three water bodies in the northeastern United States and Quebec, Canada.
Vicki S. Blazer, Peter Emerson, Matthew Bodnar, Thomas Jones, David R. Russell, Matthew Pehrson, Cheyenne R. Smith, Danielle Cleveland, Mark J. Henderson, Patricia M. Mazik   +9 more
wiley   +1 more source

Vaccination Reduces Shedding of Salmonid Alphavirus Subtype 3, but Bacterial Co‐Infection Influences the Effect

Journal of Fish Diseases, EarlyView.
ABSTRACT Waterborne horizontal transmission of viral diseases in fish relies on the release of infectious virus particles (termed shedding) into the aquatic environment. Both the rate and duration of shedding are critical for efficient viral spread, making interventions that reduce shedding valuable for disease control.
Søren Grove, H. Craig Morton, Dhamotharan Kannimuthu, HyeongJin Roh, Ravikumar M. Chovatia, Ma Michelle Peñaranda, Dawit Ghebretnsae, Kai Ove Skaftnesmo   +7 more
wiley   +1 more source

RNA packaging and uncoating in simple single-stranded RNA viruses [PDF]

, 2012
Simple (non-enveloped) small, positive-sense single-stranded RNA viruses infect hosts from all kingdoms of life. However, their assembly and uncoating processes remain poorly understood. For turnip crinkle virus (TCV), 3D reconstructions by cryoelectron
Bakker, Saskia
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