Results 71 to 80 of about 85,852 (237)

The Interplay between ESCRT and Viral Factors in the Enveloped Virus Life Cycle [PDF]

, 2021
Viruses are obligate parasites that rely on host cellular factors to replicate and spread. The endosomal sorting complexes required for transport (ESCRT) system, which is classically associated with sorting and downgrading surface proteins, is one of the
Bo Meng, Andrew M. L. Lever
core   +1 more source

Non-enveloped virus inactivation potency of sodium dodecyl sulfate with citric and glutamic acids

Frontiers in Microbiology
Disinfection is one of the most important methods by which transmission of infectious diseases can be blocked, and efficacies differ depending on how they are used and the target organism.
Yong Wah Tan, Chwee Fern Bok, Brenda Jun Fang Lim, Li Ying Kong, Kian Sim Goo, Yoshiki Ishida, Jiquan Liu, Chun Song Chua, Justin Jang Hann Chu, Justin Jang Hann Chu, Justin Jang Hann Chu, Justin Jang Hann Chu   +11 more
doaj   +1 more source

Enhancing cationic surfactants’ inactivation of non-enveloped viruses by sulfate ions

, 2022
Abstract Quaternary cationic surfactants with bactericidal activity such as didecyldimethylammonium chloride (DDAC) show an inactivation effect on enveloped viruses, but they have little effect on non-enveloped viruses such as noroviruses. Therefore, we examined additives that enhance the inactivation effect of cationic surfactants by using ...
Rei Saito, Seiichi Tobe, Miyuki Miyake, Yukari Sekine, Takeshi Takizawa, Junichi Sugiyama, Yasushi Kakizawa, Shigeru Morikawa   +7 more
openaire   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Critical Determinants of Human α-Defensin 5 Activity against Non-enveloped Viruses [PDF]

Journal of Biological Chemistry, 2012
Human α-defensins, such as human α-defensin 5 (HD5), block infection of non-enveloped viruses, including human adenoviruses (AdV), papillomaviruses (HPV), and polyomaviruses. Through mutational analysis of HD5, we have identified arginine residues that contribute to antiviral activity against AdV and HPV.
Anshu P, Gounder, Mayim E, Wiens, Sarah S, Wilson, Wuyuan, Lu, Jason G, Smith   +4 more
openaire   +2 more sources

Using cryoEM and cryoET to visualize membrane penetration of a non-enveloped virus

STAR Protocols, 2022
Summary: Key to cell entry by non-enveloped viruses is virus-cell interactions at the cell or endosomal membrane. Here, we detail our protocols to capture such interactions between non-enveloped virus bluetongue virus (BTV) and vesicular membrane by ...
Xian Xia, Z. Hong Zhou
doaj   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

The Impact of Non-pharmacological Interventions Measures Against COVID-19 on Respiratory Virus in Preschool Children in Henan, China

Journal of Epidemiology and Global Health, 2023
Objectives To investigate the long-term effects of non-pharmacological interventions (NPIs) measures on the epidemiological characteristics of common respiratory viruses in preschool children in Henan, China.
Hui Yan, Bo Zhai, Fang Yang, Penggao Wang, Yang Zhou   +4 more
doaj   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Enveloped and non-enveloped viral-like particles in Trypanosoma cruzi epimastigotes

Revista do Instituto de Medicina Tropical de São Paulo
Electron microscopy is routinely used to identify viral infections in protozoan parasites. These viruses have been described as non-enveloped and icosahedral structures with a diameter of 30-60 nm.
Ana María Fernández-Presas, Luis Padilla-Noriega, Ingeborg-Becker, Lilia Robert, José Agustín Jiménez, Sandra Solano, Jose Delgado, Patricia Tato, José Luis Molinari   +8 more
doaj   +1 more source