Results 71 to 80 of about 530,767 (267)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
NanomaterialsCopper-based materials, renowned for their redox versatility and conductivity, have extensive applications in electrochemical sensing. Herein, we construct stable Cu+/Cu2+ interfaces within dual-valence copper nanostructures to achieve enhanced ...
Zhipeng Yu +7 more
doaj +1 more source
NETS: A Non-Equilibrium Transport Sampler
CoRRWe propose an algorithm, termed the Non-Equilibrium Transport Sampler (NETS), to sample from unnormalized probability distributions. NETS can be viewed as a variant of annealed importance sampling (AIS) based on Jarzynski's equality, in which the stochastic differential equation used to perform the non-equilibrium sampling is augmented with an ...
Michael Samuel Albergo +1 more
openaire +3 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
CLASSICAL AND MULTISCALE NON-EQUILIBRIUM THERMODYNAMICS
Annals of the Academy of Romanian Scientists Series on Mathematics and Its ApplicationClassical and multiscale non-equilibrium thermodynamics have dif- ferent histories and different objectives. In this Note we explain the differences and review some topics in which the multiscale viewpoint of mesoscopic time evolution of macroscopic systems helped to advance the classical non-equilibrium thermodynamics.
Grmela, Miroslav, Pavelka, Michal
openaire +3 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Numerical simulation of critical dissipative non-equilibrium quantum systems with an absorbing state
New Journal of Physics, 2019 The simulation of out-of-equilibrium dissipative quantum many body systems is a problem of fundamental interest to a number of fields in physics, ranging from condensed matter to cosmology.
Edward Gillman +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Noisy frequency estimation with noisy probes
New Journal of Physics, 2018 We consider frequency estimation in a noisy environment with noisy probes. This builds on previous studies, most of which assume that the initial probe state is pure, while the encoding process is noisy, or that the initial probe state is mixed, while ...
Agnieszka Górecka +5 more
doaj +1 more source