Results 41 to 50 of about 10,768,989 (280)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
AerospaceNon-equilibrium condensation involves intricate physics, making it crucial to thoroughly investigate the factors that influence it. Understanding these factors is essential for optimizing the system performance and minimizing the negative effects ...
Saman Javadi Kouchaksaraei +1 more
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Free-convection condensation on single horizontal pin-fin tubes [PDF]
, 2011 PhDNew experimental data are reported for free-convection condensation of ethylene glycol and R-113 on three-dimensional pin-fin tubes. Effects of pin geometry and tube thermal conductivity (for copper, brass and bronze giving a mean range of 400, 120 ...
Ali, Hafiz-Muhummad
core +4 more sources
Kinetics of Strongly Non-equilibrium Bose-Einstein Condensation [PDF]
, 2007 We consider the ordering kinetics in a strongly non-equilibrium state of a (weakly) interacting Bose gas, characterized, on one hand, by large occupation numbers, and, on the other hand, by the absence of long-range order. Up to higher-order corrections in inverse occupation numbers, the evolution is described by non-linear Schrodinger equation with a ...
openaire +2 more sources
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Chemical Engineering Transactions, 2022 Steam condensation in tubes exhibits obvious thermodynamic non-equilibrium characteristics, which leads to many problems, such as the decline of condenser efficiency and the freezing crack of condenser under low temperature.
Yuqian Wang, Chang Huang, Weiliang Wang
doaj +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source