Results 81 to 90 of about 16,139,392 (302)
Organoids in pediatric cancer research
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Background: Medicinal plants have been used to treat various diseases for several years throughout the world. Xylanthemum macropodum is a medicinal plant with a vast application as a home remedy in Balochistan.
Maria Bibi +6 more
doaj
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
TEHIP news, issue no. 3 : completing the circle; bringing research into development
"A newsletter of the IDRC/MOH Tanzania Essential Health Interventions Project"The knowledge being generated by the Tanzania Essential Health Interventions Project (TEHIP) in research and development interventions has demonstrated the benefits of evidence-
Tanzania Essential Health Interventions Project
core +1 more source
The Effect of Fish Size and Condition on the Contents of Twelve Essential and Non Essential Elements in Aristichthys nobilis [PDF]
The correlation coefficients between fish size (body weight and total length) and metal contents (Na, K, Ca, Mg, Mn, Fe, Cu, Zn, Cr, Co, Cd and Pb) in whole fish (Aristichthys nobilis) were determined.
M. Naeem*, A. Salam, S. S. Tahir1 and N. Rauf 1
doaj
Pigs fitted with ileal T-cannula in the terminal ileum were used to study the effect of synthetic amino acids (AA) added to a nitrogen-free diet on endogenous losses.
P. Dolešová +3 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Non-Essential Cluster Values and Normal Functions [PDF]
We consider continuous functions f which map the open unit disk D into the Riemann sphere W. For a point ζ on the unit circle C, we say that χ is a chord at ζ if χ is a chord of C having one endpoint at ζ and that Δ is a Stolz angle at ζ if Δ is a Stolz angle with vertex ζ. Suppose S denotes either a chord at ζ, a Stolz angle at ζ, or D.
openaire +3 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source

