Results 141 to 150 of about 12,385,044 (225)

Serotype‐Tailored Midstream and Downstream Operations to Advance the Manufacturing of Adeno‐Associated Viral Vectors

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Adeno‐associated viruses (AAVs) are the leading vectors for in vivo gene therapy, fueling a growing demand for scalable and robust biomanufacturing processes. Yet, the impact of cell lysis conditions on the performance of midstream and downstream unit operations across serotypes remains poorly characterized.
Arianna Minzoni, Shriarjun Shastry, Eduardo Barbieri, Morgan R. Hurst, Kelvin Idanwekhai, Yuxuan Wu, Katherine Ernst, Wai‐Keen Chung, Christopher Bombeck, Saad A. Khan, Sushmita Koley, Gabriella Kiss, Oliver Rammo, Alexander Tropsha, Cristiana Boi, Michael A. Daniele, Steven Cramer, Barry Byrne, Stephen Kaminsky, Angie Snell Bennett, Stefano Menegatti   +20 more
wiley   +1 more source

Thermodynamic and Kinetic Analysis of Molecular Conformational Dynamics in a Riemannian Framework. [PDF]

J Phys Chem A
Fakharzadeh A, Goolsby C, Tajkhorshid E, Moradi M.   +3 more
europepmc   +1 more source

From muscle fibres to muscle gears: how dynamic fascicle orientation and shape change impact skeletal muscle function

Biological Reviews, EarlyView.
ABSTRACT Skeletal muscle architectural design strongly affects force‐generating capacity and excursion range, and its functional importance to animal and human movement is well founded. Traditionally, this ‘structure–function relation’ has been inferred from architecture measurements with muscles at rest (from anatomical dissections or medical imaging ...
Matheus D. Pinto, James M. Wakeling, Javier A. Almonacid, Anthony J. Blazevich   +3 more
wiley   +1 more source

The role of geometry in morphogenesis. [PDF]

Development
Harrison R, Hamant O, Saunders TE.
europepmc   +1 more source

Future Generations' Perceptions and Evaluations of Financial Intermediaries: A Multivariate Analysis in the Digital and Sustainable Era

Business Strategy and the Environment, EarlyView.
ABSTRACT The rapid digital transformation of financial services, increasing regulatory pressure and the growing strategic relevance of sustainability are reshaping financial intermediaries and how they are perceived by younger generations. In this context, traditional monetary compensation schemes are increasingly insufficient to explain how financial ...
Gerardo Petroccione, Carlo Drago, Dario Siggia   +2 more
wiley   +1 more source

Stability of Minkowski-type inequalities in certain warped product spaces. [PDF]

J Evol Equ
Sahjwani P.
europepmc   +1 more source

Bolapolyphiles With Bulky Carbosilane‐Based Lateral Groups—Reticular Design of Liquid Crystalline Pentagonal Honeycombs

Chemistry – A European Journal, EarlyView.
T‐shaped bolapolyphiles with highly branched carbosilane‐based side‐groups self‐assemble into liquid crystalline honeycombs composed of type‐2 pentagonal prismatic cells and p2gg plane group symmetry. ABSTRACT Periodic pentagon tessellations are rarely observed in self‐assembled molecular systems.
Christian Anders, Matthias Wagner, Silvio Poppe, Carsten Tschierske   +3 more
wiley   +1 more source

Diffusion-Based Protein Structure Design: Geometric Modelling, Validation Strategies, and Thermodynamic Challenges. [PDF]

Int J Mol Sci
Li W, Cadet X, Medina-Ortiz D, Davari MD, Sowdhamini R, Bessafi M, Damour C, Li Y, Miranville A, de Brevern AG, Cadet F.   +10 more
europepmc   +1 more source

Optimal subsampling for regression with mixed‐type predictors

Canadian Journal of Statistics, EarlyView.
Abstract Subsampling has emerged as an appealing strategy to mitigate the computational and storage challenges imposed by large datasets. Recent subsampling techniques have shown notable computational gains for data dominated by numerical predictors. However, real‐world datasets frequently contain both numerical and categorical predictors.
Jiaqing Zhu, Lin Wang, Fasheng Sun
wiley   +1 more source

ScGeo reveals non-canonical trajectories beyond RNA velocity in radiation-induced hematopoietic recovery. [PDF]

Bioinform Adv
Liu YC, Yoshida K.
europepmc   +1 more source