Results 91 to 100 of about 1,440,432 (297)
Quantile and probability curves without crossing [PDF]
The most common approach to estimating conditional quantile curves is to fit a curve, typically linear, pointwise for each quantile. Linear functional forms, coupled with pointwise fitting, are used for a number of reasons including parsimony of the ...
Alfred Galichon +2 more
core
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Enzyme activity and dynamics in near-anhydrous conditions [PDF]
, 2009 Water is widely assumed to be essential for life 1, although the exact molecular basis of this requirement is unclear 2-4. Water facilitates protein motions 5-9 and although enzyme activity has been demonstrated at low hydrations in organic solvents 10 ...
Jeremy Smith +6 more
core +1 more source
Self-supporting structure design in additive manufacturing through explicit topology optimization
, 2017 One of the challenging issues in additive manufacturing (AM) oriented topology optimization is how to design structures that are self-supportive in a manufacture process without introducing additional supporting materials. In the present contribution, it
Du, Zongliang +5 more
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Group Structure as a Foundation for Entropies
EntropyEntropy can signify different things. For instance, heat transfer in thermodynamics or a measure of information in data analysis. Many entropies have been introduced, and it can be difficult to ascertain their respective importance and merits.
Henrik Jeldtoft Jensen +1 more
doaj +1 more source
Исследование стоимости и трудоёмкости разработки программного обеспечения для решения задачи управления запасами предприятия [PDF]
, 2018 The article describes the process of estimating the cost and complexity of software development for the task of inventory management of a commercial enterprise to improve the decision-making process at the stage of formation of requirements for similar ...
Huzhva, Viktor Oleksiiovych +1 more
core
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
An Efficient Framework for Order Optimization [PDF]
, 2003 Since the introduction of cost-based query optimization, the performance-critical role of interesting orders has been recognized. Some algebraic operators change interesting orders (e.g.
Moerkotte, Guido, Neumann, Thomas
core
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source