Results 81 to 90 of about 1,440,432 (297)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Robust Stability Analysis of Switching Time-Delay Systems via a Novel Non-Monotonic Lyapunov–Krasovskii Approach [PDF]

International Journal of Research and Technology in Electrical Industry
In this paper, a novel approach based on a non-monotonic Lyapunov–Krasovskii functional is first proposed for the comprehensive stability analysis of discrete-time switched systems with time delays in an m-step-ahead scheme.
Saeed Ahmadi, Younes Solgi
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Endovascular control of haemorrhagic urological emergencies: an observational study

BMC Urology, 2006
Background Transarterial embolisation (TAE) is an effective method in control of haemorrhage irrespective of the nature of urological emergency. As the technique and technology have evolved, it is now possible to perform highly selective embolisation ...
Thorpe Peter, Nabi Ghulam, Somani Bhaskar K, McClinton Sam   +3 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

On the Effectiveness of Zero-Shot and Few-Shot Pretrained Language Models for Software Requirement Classification

IEEE Access
Accurate classification of software requirements, particularly distinguishing between fun- ctional and non-functional requirements, is essential for enabling traceability, guiding system design, and ensuring project success.
Md Shafikuzzaman, Md Rakibul Islam, Shuaib Zaman, Andrew Ma, Anwarul Islam Sifat   +4 more
doaj   +1 more source

Design of safety critical and control systems of Nuclear Power Plants using Petri nets

Nuclear Engineering and Technology, 2019
Non-functional requirements plays a critical role in designing variety of applications domain ranges from safety-critical systems to simple gaming applications.
Pooja Singh, Lalit Kumar Singh
doaj   +1 more source

Requirement Engineering for Non-Functional Requirements

, 2015
Both functional and non-functional requirements (NFRs) must be considered when developing software products. Requirements engineering (RE) is the early phase of software development activity in which the system requirements are developed and managed.
Alashqar, Abdelkareem M, Elfetouh, Ahmad Abo, El-Bakry, Hazem M   +2 more
openaire  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source