Results 111 to 120 of about 665,168 (288)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

FRUIT: Fuzzy Representation of Unbounded and Imprecise Terms in Non-Functional Requirements

IEEE Access
It is challenging to verify Non-Functional Requirements (NFRs) because the traditional verification process typically uses the binary concept of true or false to determine whether a requirement has been fulfilled, leaving no space for uncertainty, even ...
Franklin Parrales-Bravo, Rosangela Caicedo-Quiroz, Julio Barzola-Monteses, Leonel Vasquez-Cevallos   +3 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Quality Requirements in Agile as a Knowledge Management Problem: More than Just-in-Time

, 2017
Just-in-time (JIT) approaches have been suggested for managing non-functional requirements in agile projects. However, many non-functional requirements cannot be raised and met on the spot.
Liebel, Grischa,, Knauss, Eric, Kurt Schneider, Eric Knauss, Schneider, Kurt, Horkoff, Jennifer,, Grischa Liebel, KASAULI, RASHIDA, Jennifer Horkoff, Rashidah Kasauli, Kasauli, Rashida,, Horkoff, Jennifer, Knauss, Eric,, Kasauli, Rashidah,, Liebel, Grischa, Schneider, Kurt,   +15 more
core   +1 more source

An Architecture Assessment Model: Holistic Evaluation of Software Architecture

IEEE Access
Current architecture review methods predominantly focus on verifying compliance between design and requirements, as well as between code and design. However, they often overlook whether the final product has been adequately tested against architecturally
Mujdat Bayar, Onur Taviloglu, Ahmet Unudulmaz, Yavuz Gunes, Koray Dogutekin   +4 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Scoping of Non-Functional Requirements for Machine Learning Systems

Machine Learning (ML) systems increasingly perform complex decision-making and prediction tasks - e.g., in autonomous driving - based on patterns inferred from large quantities of data.
Habibullah, Khan Mohammad,, Horkoff, Jennifer,, Garcia Diaz, Juan,, Gay, Gregory,   +3 more
core   +1 more source

Automated Classification and Identification of Non-Functional Requirements in Agile-Based Requirements Using Pre-Trained Language Models

IEEE Access
Non-functional requirements (NFRs) are critical factors for software quality and success. A frequently reported challenge in agile requirements engineering is that NFRs are often neglected due to the focus on functional requirements (FRs) and the limited
Abdulrahim Alhaizaey, Majed Al-Mashari
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source