Results 141 to 150 of about 665,168 (288)

Challenges in COTS decision-making: a goal-driven requirements engineering perspective

, 2002
This position paper outlines the problems and risks of selecting COTS products. In particular, we highlight the challenges of the decision-making process where requirements specification plays an essential role to evaluate and compare products features ...
Finkelstein, A., Alves, C.
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Mobile-Based Medication Management Applications: A Scoping Review of Functional and Non-Functional Requirements. [PDF]

Healthc Technol Lett
Malekzadeh S, Ayatollahi H, Toni E.
europepmc   +1 more source

Modelling non-functional requirements

, 2001
We present in this paper the language NoFun for stating component quality in the framework of the ISO/IEC quality standards. The language consists of three different parts. In the first one, software quality characteristics and attributes are defined, probably in a hierarchical manner.
Botella López, Pere, Burgués Illa, Xavier, Franch Gutiérrez, Javier, Huerta, Mario, Salazar, Guadalupe   +4 more
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Rethinking the Notion of Non-Functional Requirements

, 2005
. Requirements standards and textbooks typically classify requirements into functional requirements on the one hand and attributes or non-functional requirements on the other hand.
Martin Glinz
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Identification and Prioritization of Requirements for a Home-Based Tele-Rehabilitation Information System for Cerebral Palsy Patients: A Delphi Study. [PDF]

Health Sci Rep
Salahshoori F, Jangi M, Sadeghi-Demneh E, Fatehi F, Rahimi A.   +4 more
europepmc   +1 more source