Results 81 to 90 of about 665,168 (288)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Re-Distill: A Multi-Stage Retrieval Framework for Functional–Non-Functional Requirement Linking in Software Engineering

open access: yesApplied Sciences
Non-functional requirements (NFRs) are critical for ensuring software quality, yet they remain difficult to identify due to their implicit and loosely defined relationship with functional requirements (FRs). Existing research predominantly focuses on NFR
Ashwag Almohammady   +2 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Evaluation model for non-functional requirements of a software product [PDF]

open access: yes, 2016
Evaluation of Non-functional requirements (NFRs) of a software product is a key to achieve high quality software. Non-functional requirements define how a system should perform and capture required properties of a system, such as timing, and reliability.
Montoya Pérez, yury
core  

A Review of Non-Functional Requirements Analysis Throughout the SDLC

open access: yesComputers
To date, unquestionable efforts have been made, both in academia and industry, to facilitate the development of functional requirements (FRs) throughout the different phases of the software development life cycle (SDLC).
Cyrille Dongmo
doaj   +1 more source

Requirements Engineering Contributions on the Development of Educational Software for the Blind or People with Impaired Vision

open access: yesCLEI Electronic Journal, 2006
This paper presents an account of the experience observed when obtaining a set of requirements for the development of educational software for people with impaired vision.
Victor Francisco Araya Santander   +1 more
doaj   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

The Functional and Non-Functional Requirements of a Telemedicine System for Chronic Pain Management [PDF]

open access: yesمجله انفورماتیک سلامت و زیست پزشکی
Introduction: With the expansion of information and communication technologies, telemedicine systems have become a key tool in enhancing the quality of healthcare services.
Zeinab Kohzadi   +6 more
doaj  

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