Results 61 to 70 of about 278,238 (326)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
NGO impact on ensuring the quality of higher education in departmental HEIs
Університети і лідерство, 2020 The process of higher education quality assurance is a strategic priority for the development of higher education in Ukraine. To meet the EHEA standards in the sphere of higher education for the Ukrainian HEIS to cooperate with European ones; the ...
Kateryna Tryma, Natalia Salnikova
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
A Reflection on First Nations in their Boreal Homelands in Ontario: Between a Rock and a Caribou
Conservation & Society, 2015 This article provides some thoughts on the impacts of the conservation vs development paradigm on First Nations, as it has played out in the Canadian Boreal Forest Agreement and the Far North Act in northern Ontario, Canada.
M A Smith
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Lessons for Co-management: Experiences from the Fisheries Management Science Programme (FMSP) [PDF]
, 2006 The aim of this document is to communicate lessons for fisheries co-management that have emerged from a series of projects undertaken by the DFID Fisheries Management Science Programme (FMSP).
Charlotte Howard, Robert Arthur
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Mango trees, offices and altars: the role of relatives, non-governmental organisations and churches after rape in northern Uganda [PDF]
, 2015 This article reflects on why so many women never access justice or take advantage of available services after rape in northern Uganda. It focuses on roles of three prominent non-governmental actors: lineage-based kinship authority, churches, and ...
Porter, Holly E.
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Role of non-governmental organisations in operations research in low-resource countries
The Lancet Global Health, 2014 Background: Research partnerships among practitioners, researchers, and affected communities are increasingly seen as important vehicles for translating findings to operational strategies.
Dr. Florence Nyangara, PhD
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Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source