Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio with all-cause mortality and cardio-cerebrovascular disease mortality in elderly patients with cardiovascular-kidney-metabolic syndrome stages 0-3: a cohort study. [PDF]
Xu S +6 more
europepmc +1 more source
A 70‐year‐old man with recurrent cerebral infarctions, a subdural hematoma, and atherosclerotic disease involving multiple extracranial vascular territories was subsequently diagnosed with polycythemia vera (PV). In patients with recurrent cerebrovascular events accompanied by otherwise unexplained persistent erythrocytosis, JAK2 mutation testing and ...
Hui Zhao +5 more
wiley +1 more source
Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and cognitive impairment in patients with cerebral small vessel disease. [PDF]
Wang C +10 more
europepmc +1 more source
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li +29 more
wiley +1 more source
J-shaped association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and heart failure: a cross-sectional study. [PDF]
Lv P, Zhao C, Shan Y.
europepmc +1 more source
Gut Enterococcus faecium derived leucic acid mediates the antiobesity effect of dietary fiber
This study identified Enterococcus faecium as a gut bacterium with anti‐obesity activity, which alleviated adipocyte hypertrophy, dyslipidemia, and hepatic steatosis by converting leucine into leucic acid (LEA) to regulate mitochondrial oxidative phosphorylation.
Baifei Hu +9 more
wiley +1 more source
Cotrimoxazole use is associated with lower total and non-high density lipoprotein cholesterol among people with HIV: a cross-sectional study. [PDF]
Baluku JB +4 more
europepmc +1 more source
Metrnl: A Novel Therapeutic Target in Atherosclerosis
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley +1 more source
Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and high-sensitivity C-reactive protein in US adults: Results from NHANES 2015-2018. [PDF]
Wang H, Chen H, Li J, Peng Y.
europepmc +1 more source
ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang +5 more
wiley +1 more source

