Results 111 to 120 of about 1,031,153 (395)

Primate modularity and evolution: first anatomical network analysis of primate head and neck musculoskeletal system [PDF]

, 2018
Network theory is increasingly being used to study morphological modularity and integration. Anatomical network analysis (AnNA) is a framework for quantitatively characterizing the topological organization of anatomical structures and providing an ...
A Goswami, A Porto, A Porto, AM Burrows, B Esteve-Altava, B Esteve-Altava, B Esteve-Altava, B Esteve-Altava, B Hallgrímsson, B Hallgrímsson, B Hallgrímsson, BM Waller, C Rolian, CF Ross, D Rasskin-Gutman, DE Lieberman, E Bullmore, G Marroig, G Marroig, GB Müller, GP Wagner, GP Wagner, J Ahn, KL Lewton, KL Schmidt, L Scheider, L Scheider, LA Parr, LR Monteiro, M Bastir, ML Moss, ML Zelditch, NM Young, NM Young, P Mitteroecker, R Cornette, R Diogo, R Diogo, R Laffont, RR Ackermann, RR Ackermann, SE Santana, SE Santana, SR Jackson, T Saucède, WR Atchley, X Li   +46 more
core   +2 more sources

Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD

Advanced Science, EarlyView.
TDP‐43 dysfunction disrupts RNA processing, inducing cryptic exon 4a1 inclusion in GAP43 and reducing its protein levels. This aberrant splicing impairs axonal regeneration and contributes to neurodegeneration in ALS and AD. RNA‐seq of patient brains reveals GAP43 downregulation and 4a1 upregulation, identifying cryptic exon 4a1 as a potential ...
Mingming Yang, Qi Wang, Dongkun Kang, Shijia Wang, Yanli Jiang, Jian‐Zhi Wang, Chen Ming, Rong Liu, Jianlan Gu, Xiaochuan Wang   +9 more
wiley   +1 more source

Intranasal delivery of small extracellular vesicles reduces the progress of amyotrophic lateral sclerosis and the overactivation of complement-coagulation cascade and NF-ĸB signaling in SOD1 G93A mice

Journal of Nanobiotechnology
Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive motoneuron degeneration, and effective clinical treatments are lacking.
Jinrui Zhou, Fuxiang Li, Bin Jia, Zicong Wu, Zhonghai Huang, Meiting He, Huandi Weng, Kwok-Fai So, Wenrui Qu, Qing-Ling Fu, Libing Zhou   +10 more
doaj   +1 more source

Abnormal outer and inner retina in a mouse model of Huntington’s disease with age

Frontiers in Aging Neuroscience
Huntington’s disease (HD) is a progressive neurodegenerative disorder characterized by motor dysfunction and cognitive decline. While retinal abnormalities have been documented in some HD patients and animal models, the nature of these abnormalities ...
Dashuang Yang, Chunhui Huang, Chunhui Huang, Xuemeng Guo, Yintian Li, Jiaxi Wu, Zaijun Zhang, Zaijun Zhang, Zaijun Zhang, Sen Yan, Ying Xu, Ying Xu   +11 more
doaj   +1 more source

Strengths and challenges of longitudinal non-human primate neuroimaging

NeuroImage, 2021
Longitudinal non-human primate neuroimaging has the potential to greatly enhance our understanding of primate brain structure and function. Here we describe its specific strengths, compared to both cross-sectional non-human primate neuroimaging and ...
Xiaowei Song, Pamela García-Saldivar, Nathan Kindred, Yujiang Wang, Hugo Merchant, Adrien Meguerditchian, Yihong Yang, Elliot A. Stein, Charles W. Bradberry, Suliann Ben Hamed, Hank P. Jedema, Colline Poirier   +11 more
doaj  

Towards A Microbead Occlusion Model of Glaucoma for a Non-Human Primate

Scientific Reports, 2019
Glaucoma is a group of optic neuropathies associated with aging and sensitivity to intraocular pressure (IOP). The disease causes vision loss through the degeneration of retinal ganglion cell neurons and their axons in the optic nerve. Using an inducible
W. Lambert, Brian J. Carlson, Purnima Ghose, Victoria Vest, Vincent Yao, David J. Calkins   +5 more
semanticscholar   +1 more source

Genetics‐Based Targeting Strategies for Precise Neuromodulation

Advanced Science, Volume 12, Issue 28, July 24, 2025.
In this Review, the fundamental principles and implementation protocols of genetics‐based precision neuromodulation are first introduced. Then, wireless and low‐invasive strategies based on nano‐transducing materials are highlighted, along with a dissection and analysis of the strengths and weaknesses of representative studies.
Yuyuan He, Zhidong Wei, Jianda Xu, Fei Jin, Tong Li, Lili Qian, Juan Ma, Weiying Zheng, Negar Javanmardi, Ting Wang, Kangjian Sun, Zhang‐Qi Feng   +11 more
wiley   +1 more source

Anticarin-β shows a promising anti-osteosarcoma effect by specifically inhibiting CCT4 to impair proteostasis

Acta Pharmaceutica Sinica B, 2022
Unlike healthy, non-transformed cells, the proteostasis network of cancer cells is taxed to produce proteins involved in tumor development. Cancer cells have a higher dependency on molecular chaperones to maintain proteostasis.
Gan Wang, Min Zhang, Ping Meng, Chengbo Long, Xiaodong Luo, Xingwei Yang, Yunfei Wang, Zhiye Zhang, James Mwangi, Peter Muiruri Kamau, Zhi Dai, Zunfu Ke, Yi Zhang, Wenlin Chen, Xudong Zhao, Fei Ge, Qiumin Lv, Mingqiang Rong, Dongsheng Li, Yang Jin, Xia Sheng, Ren Lai   +21 more
doaj  

An Evaluation of Twenty Years of EU Framework Programme-funded Immune-mediated Inflammatory Translational Research in Non-human Primates

Frontiers in Immunology, 2016
Ageing western societies are facing an increasing prevalence of chronic inflammatory and degenerative diseases for which often no effective treatments exist, resulting in increasing health care expenditure.
Krista Geraldine Haanstra, Margreet Jonker, Margreet Jonker, Bert A 't Hart, Bert A 't Hart   +4 more
doaj   +1 more source

A high-resolution map of human evolutionary constraint using 29 mammals. [PDF]

, 2011
The comparison of related genomes has emerged as a powerful lens for genome interpretation. Here we report the sequencing and comparative analysis of 29 eutherian genomes.
Alföldi, Jessica, Baldwin, Jen, Baylor College of Medicine Human Genome Sequencing Center Sequencing Team, Beal, Kathryn, Birney, Ewan, Bloom, Toby, Broad Institute Sequencing Platform and Whole Genome Assembly Team, Chang, Jean, Chin, Chee Whye, Clamp, Michele, Clawson, Hiram, Cree, Andrew, Cuff, James, Delehaunty, Kim, Di Palma, Federica, Dihn, Huyen H, Dooling, David, Ernst, Jason, Fitzgerald, Stephen, Flicek, Paul, Fowler, Gerald, Fronik, Catrina, Fulton, Bob, Fulton, Lucinda, Garber, Manuel, Genome Institute at Washington University, Gibbs, Richard A, Gnerre, Sante, Goldman, Nick, Graves, Tina, Green, Eric D, Guttman, Mitchell, Haussler, David, Heiman, Dave, Herrero, Javier, Holloway, Alisha K, Hubisz, Melissa J, Jaffe, David B, Jhangiani, Shalili, Jordan, Gregory, Joshi, Vandita, Jungreis, Irwin, Kellis, Manolis, Kent, W James, Kheradpour, Pouya, Kostka, Dennis, Kovar, Christie L, Lander, Eric S, Lara, Marcia, Lee, Sandra, Lewis, Lora R, Lin, Michael F, Lindblad-Toh, Kerstin, Lowe, Craig B, Mardis, Elaine R, Margulies, Elliott H, Martins, Andre L, Massingham, Tim, Mauceli, Evan, Minx, Patrick, Moltke, Ida, Muzny, Donna M, Nazareth, Lynne V, Nicol, Robert, Nusbaum, Chad, Okwuonu, Geoffrey, Parker, Brian J, Pedersen, Jakob S, Pollard, Katherine S, Raney, Brian J, Rasmussen, Matthew D, Robinson, Jim, Santibanez, Jireh, Siepel, Adam, Sodergren, Erica, Stark, Alexander, Vilella, Albert J, Ward, Lucas D, Warren, Wesley C, Washietl, Stefan, Weinstock, George M, Wen, Jiayu, Wilkinson, Jane, Wilson, Richard K, Worley, Kim C, Xie, Xiaohui, Young, Sarah, Zody, Michael C, Zuk, Or   +88 more
core   +1 more source