Results 91 to 100 of about 17,406,766 (301)

Abnormal outer and inner retina in a mouse model of Huntington’s disease with age

Frontiers in Aging Neuroscience
Huntington’s disease (HD) is a progressive neurodegenerative disorder characterized by motor dysfunction and cognitive decline. While retinal abnormalities have been documented in some HD patients and animal models, the nature of these abnormalities ...
Dashuang Yang, Chunhui Huang, Chunhui Huang, Xuemeng Guo, Yintian Li, Jiaxi Wu, Zaijun Zhang, Zaijun Zhang, Zaijun Zhang, Sen Yan, Ying Xu, Ying Xu   +11 more
doaj   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng, Wen Gao, Jonathan Do, Danli Lu, Ying‐Wei Lan, Andreas Damianos, Gautam Verma, Ali Al Siraj, Isabella Lowry, Lance Peter, Nicholas E. Banovich, Fei Sun, Hua He, Tanya V. Kalin, Vladimir V. Kalinichenko   +14 more
wiley   +1 more source

Caspase-4 transgenic mice exhibit cytoplasmic TDP-43 accumulation and age-dependent neuropathology

Nature Communications
TAR DNA-binding protein (TDP-43) is a multifunctional protein that binds DNA and RNA within the nucleus. In neurodegenerative diseases like Amyotrophic Lateral Sclerosis (ALS), TDP-43 is mislocalized to the cytoplasm, forming inclusions.
Qingqing Jia, Longhong Zhu, Dandan Li, Zhenchun Nan, Junqi Hou, Yue Zhao, Gaolu Zhu, Kaili Ou, Mingwei Guo, Huajie Dui, Xiangyi Liu, Xiao-Xin Yan, Su Yang, Li’an Huang, Dongsheng Fan, Shihua Li, Xiao-Jiang Li, Peng Yin   +17 more
doaj   +1 more source

Improved Simultaneous Multislice EPI Reconstruction for Diffusion MRI using regularized iterative phase error-corrected SENSE

NeuroImage
Simultaneous multi-slice echo planar imaging (SMS-EPI) has significantly advanced diffusion MRI by enabling efficient whole-brain coverage at high spatial resolution.
Mengqi Wang, Yunlin Zhao, Mengye Lyu, Ed X. Wu, Yilong Liu   +4 more
doaj   +1 more source

Printing‐Assisted Integration of Thermal, Fluidic and Electrical Components in Implants for Focal Brain Cooling

Advanced Science, EarlyView.
Extrusion‐based 3D printing of silicones and discrete electronic components are combined to create cortical implants for rodents that integrate thermal neuromodulation and electrical recording. Linked to an autonomous auxiliary driver unit, the system enables rapid, stable and localized hypothermia alongside ECoG recording.
Spencer Ryan Moore, Naomi King, Aruã Clayton Da Silva, Clare Howarth, Jason Berwick, Thomas E. Paterson, Ivan R. Minev   +6 more
wiley   +1 more source

The knockout of Moesin leads to excess microglia-mediated synaptic pruning and impairs social novelty in a mouse model

Cell Reports
Summary: Genome-wide association studies (GWASs) have implicated a noncoding antisense RNA designated as MSNP1AS (Moesin pseudogene 1, antisense) in susceptibility to autism spectrum disorders (ASDs).
Wanjing Lai, Junlin Chen, Hongyao Zhu, Yunbo Jiang, Yimei Niu, Qingpei Chen, Zhihua Luo, Yu Hu, Li Fang, Yaxuan Wang, Youqiang Song, Charlly Kao, Jubao Duan, Kwok-Fai So, Hakon Hakonarson, Li Zhang, Kai Wang, Lingling Shi   +17 more
doaj   +1 more source

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source

MPP8 Facilitates DNA DSB Repair via NHEJ to Promote Chemoresistance of TNBC Independent of Methyl‐H3K9 Binding

Advanced Science, EarlyView.
Chemoresistance is often linked to elevated DNA repair. MPP8 is found to promote breast cancer chemoresistance as a novel NHEJ accessory factor independent of its epigenetic functions. Through multiple protein interactions, MPP8 facilitates association of DNAPK and ligase complexes to promote DNA repair progression.
Rupa Kumari, Jia Fang
wiley   +1 more source

Evidence of public engagement with science: visitor learning at a zoo-housed primate research centre [PDF]

, 2012
Primate behavioural and cognitive research is increasingly conducted on direct public view in zoo settings. The potential of such facilities for public engagement with science is often heralded, but evidence of tangible, positive effects on public ...
Kate Peirce, Waller Bridget M., Mitchell Heidi, Waller, Bridget, Heidi Mitchell, Peirce, Kate, Micheletta Jerome, Jerome Micheletta, Kate Peirce (137070), Bridget M. Waller (137067), Jerome Micheletta (137076), Bridget M. Waller, Heidi Mitchell (137074), Peirce Kate, Mitchell, H., Micheletta, Jerome, Bridget M Waller, Mitchell, Heidi, Waller, Bridget M.   +18 more
core   +2 more sources