Results 81 to 90 of about 17,406,766 (301)

Intranasal delivery of small extracellular vesicles reduces the progress of amyotrophic lateral sclerosis and the overactivation of complement-coagulation cascade and NF-ĸB signaling in SOD1 G93A mice

Journal of Nanobiotechnology
Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive motoneuron degeneration, and effective clinical treatments are lacking.
Jinrui Zhou, Fuxiang Li, Bin Jia, Zicong Wu, Zhonghai Huang, Meiting He, Huandi Weng, Kwok-Fai So, Wenrui Qu, Qing-Ling Fu, Libing Zhou   +10 more
doaj   +1 more source

Primate conservation—new reports from the field

, 2020
First paragraph: The September 2020 tally of the IUCN Species Survival Commission Primate Specialist Group lists 507 species, 716 subspecies and 80 genera of primates.
Williamson, Elizabeth A, Rylands, Anthony B, Mittermeier, Russell A   +2 more
core   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Non-invasive documentation of primate voice production using electroglottography

, 2018
Electroglottography (EGG) is a low-cost, non-invasive method for documenting laryngeal sound production during vocalization. The EGG signal represents relative vocal-fold contact area and thus delivers physiological evidence of vocal-fold vibration ...
Christian T. Herbst (16657626), JACOB C. DUNN, CHRISTIAN T. HERBST, Jacob C. Dunn (9230134)   +3 more
core   +4 more sources

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Species-dependent activities of the PINK1–parkin axis

Translational Neurodegeneration
In vitro studies have established that PTEN-induced putative kinase 1 (PINK1) and parkin are central regulators of mitophagy, and loss-of-function mutations in either gene can cause early-onset Parkinson’s disease (PD).
Wei Huang, Kecheng Chen, Jiayi Wen, Tong Zhang, Shihua Li, Xiao-Jiang Li, Weili Yang   +6 more
doaj   +1 more source

Quantitative Consistency of Amide Proton Transfer-Weighted MRI for Brain Tumor Differentiation: Systematic Review of Clinical Evidence

Tomography
Background/Objectives: Accurate grading of brain gliomas is important, and amide proton transfer-weighted (APTw) MRI shows promise for non-invasive tumor differentiation. This study aimed to perform a comprehensive review and meta-analyses to demonstrate
Julius Juhyun Chung, Tianwen Ma, Phaethon Philbrook, Toby Zhou, Adam Ezra Goldman-Yassen, Phillip Zhe Sun   +5 more
doaj   +1 more source

Accelerating the evolution of nonhuman primate neuroimaging [PDF]

, 2020
Nonhuman primate neuroimaging is on the cusp of a transformation, much in the same way its human counterpart was in 2010, when the Human Connectome Project was launched to accelerate progress.
Rushworth, Matthew, Milham, M, Roumazeilles, Lea, Margulies, DS, Mitchell, Anna, Sallet, Jerome, Petkov, CI   +6 more
core   +1 more source

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source

Application of antisense oligonucleotide drugs in amyotrophic lateral sclerosis and Huntington’s disease

Translational Neurodegeneration
Amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD) are diverse in clinical presentation and are caused by complex and multiple factors, including genetic mutations and environmental factors.
Kaili Ou, Qingqing Jia, Dandan Li, Shihua Li, Xiao-Jiang Li, Peng Yin   +5 more
doaj   +1 more source