Results 71 to 80 of about 17,406,766 (301)
primate-probes-matches.lastz.tar.bz2
, 2011 TAB-delimited LASTZ output from matches of probes in all-probes.fasta to the primate genomes in Supplementary Table 2. We parsed this file to remove duplicates.
Brant C. Faircloth (143432) +11 more
core +1 more source
Advanced Science, EarlyView.Neuromodulation strategies are increasingly needed to stimulate, restore, or replace altered neuronal activity in disease. Cobalt ferrite‐barium titanate (CFO–BTO) magnetoelectric nanoparticles convert low‐intensity static magnetic fields into local electrical modulation of cortical networks.
Nathalia Cancino‐Fuentes +13 more
wiley +1 more source
RNA-Targeting CRISPR/CasRx system relieves disease symptoms in Huntington’s disease models
Molecular NeurodegenerationBackground HD is a devastating neurodegenerative disorder caused by the expansion of CAG repeats in the HTT. Silencing the expression of mutated proteins is a therapeutic direction to rescue HD patients, and recent advances in gene editing technology ...
Yingqi Lin +17 more
doaj +1 more source
Touchscreen-based cognitive tasks reveal age-related impairment in a primate aging model, the grey mouse lemur (Microcebus murinus) [PDF]
, 2014 Mouse lemurs are suggested to represent promising novel non-human primate models for aging research. However, standardized and cross-taxa cognitive testing methods are still lacking.
Sandra Ammersdörfer (641760) +15 more
core +2 more sources
Advanced Science, EarlyView.Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem +24 more
wiley +1 more source
Supaglutide alleviates hepatic steatosis in monkeys with spontaneous MASH
Diabetology & Metabolic SyndromeBackground Glucagon-like peptide 1 (GLP-1) is an incretin hormone and plays an important role in regulating glucose homeostasis. GLP-1 has a short half-life due to degrading enzyme dipeptidyl peptidase-IV and rapid kidney clearance, which limits its ...
Qinghua Wang +9 more
doaj +1 more source
, 2013 Two small molecule aryl fluorides chosen for radiofluorination and non-human primate PET imaging presented here.
Constanze N. Neumann (388456) +7 more
core +1 more source
Advanced Science, EarlyView.A clinically translatable cell line can be engineered to produce leptin, encapsulated in biomaterial and safely implanted to produce and deliver the metabolic regulating protein within the body. Implantation of these encapsulated cells decreases the time it takes for mice and non‐human primates to adjust to circadian disruptions similar to those ...
Samantha T. Fleury +18 more
wiley +1 more source
A Study of Spontaneous Self-Injurious Behavior and Neuroimaging in Rhesus Macaques
ResearchNonsuicidal self-injury (NSSI) demonstrates escalating prevalence among adolescents as a maladaptive behavior characterized by deliberate self-harm, yet its neurobiological underpinnings remain elusive.
Ya-Li Zhang +30 more
doaj +1 more source
Advanced Science, EarlyView.Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu +11 more
wiley +1 more source