Results 51 to 60 of about 17,406,766 (301)

Abundant human DNA contamination identified in non-primate genome databases. [PDF]

, 2011
During routine screens of the NCBI databases using human repetitive elements we discovered an unlikely level of nucleotide identity across a broad range of phyla.
Rachel J O'Neill, Michael J. O'Neill, Mark S Longo, Michael J O'Neill, Mark S. Longo, Rachel J. O'Neill   +5 more
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Cryobiology of non-human primate oocytes [PDF]

Human Reproduction, 1996
The responses to various stresses involved with cryopreservation protocols were investigated using non-human primate oocytes. Fluorescence microscopy was used to assess the status of the F-actin microfilament system of rhesus monkey oocytes after exposure to different concentrations of glycerol.
A I, Younis, M, Toner, D F, Albertini, J D, Biggers   +3 more
openaire   +2 more sources

Self‐Sealing Microneedles Improve Precision and Reduce Reflux in Subretinal Cell Transplantation

Advanced Materials Technologies, EarlyView.
Ultrafine 49G microneedles enable subretinal delivery of induced pluripotent stem cell‐derived retinal pigment epithelial cells through a 50 µm outer diameter tip. Compared with conventional 38G microcannulas, these microneedles reduce cell suspension reflux in a rabbit model, highlighting the potential of microinvasive delivery instruments to improve ...
Jared Ching, Hinako Ichikawa, Aya Motoyoshi, Shin Tanaka, Liam Morrow, Satoshi Shirae, Noriko Sakai, Shohei Kitahata, Michiko Mandai, Kazuaki Kadonosono   +9 more
wiley   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington’s disease mice

Cell Death and Disease
Huntington’s disease (HD) is a monogenic neurodegenerative disease, caused by the CAG trinucleotide repeat expansion in exon 1 of the Huntingtin (HTT) gene. The HTT gene encodes a large protein known to interact with many proteins.
Laiqiang Chen, Yiyang Qin, Tingting Guo, Wenzhen Zhu, Jingpan Lin, Tingting Xing, Xuezhi Duan, Yiran Zhang, Eshu Ruan, Xiang Li, Peng Yin, Shihua Li, Xiao-Jiang Li, Su Yang   +13 more
doaj   +1 more source

Aging in Non-Human Primate Society: What Relevance for Social Gerontology?

Anthropology & Aging, 2023
Wild animals were once thought not to age, as their deaths were viewed as the consequences of constant exposure to the perennial risks of nature. Studies of non-human aging were largely confined to biological investigations, focusing upon short-lived ...
Chris Gilleard
doaj   +1 more source

Culture in Non-human Primates: Definitions and Evidence [PDF]

, 2013
The attribution of culture to non-human animals has been controversial and continues to fuel much heated debate, much of which hinges on how culture is defined.
Newton-Fisher, Nicholas E., Humle, Tatyana   +1 more
core  

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

Advanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

Antimicrobial resistance and mechanisms of epigenetic regulation

Frontiers in Cellular and Infection Microbiology, 2023
The rampant use of antibiotics in animal husbandry, farming and clinical disease treatment has led to a significant issue with pathogen resistance worldwide over the past decades. The classical mechanisms of resistance typically investigate antimicrobial
Xinrui Wang, Xinrui Wang, Donghong Yu, Donghong Yu, Lu Chen, Lu Chen   +5 more
doaj   +1 more source