Results 41 to 50 of about 17,406,766 (301)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
GAS-STING: a classical DNA recognition pathways to tumor therapy
Frontiers in Immunology, 2023 Cyclic GMP-AMP synthetase (cGAS), recognized as the primary DNA sensor within cells, possesses the capability to identify foreign DNA molecules along with free DNA fragments.
Xinrui Wang +10 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau +11 more
wiley +1 more source
A Novel Genetic TDP‐43 Pig Model Mimics Multiple Key ALS‐Like Features
MedCommAmyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that lacks ideal models to comprehensively recapitulate its pathological features. TDP‐43 pathology, a hallmark of neurodegenerative diseases, plays a critical role in disease
Chunhui Huang +17 more
doaj +1 more source
Additional file 1 of Complex structural variations in non-human primate hepatitis B virus
, 2021 Additional file 1. List of human HBV sequences. List of non-human primate HBVs. Table S1. Percent identities among Wendy, human HBV/A-I, and non-human primate HBVs in 100 bp of 5’ side of the 6nt insertion specific to HBV/A in the Core region.
Kentaro Matsuura (156545) +5 more
core +1 more source
Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen +6 more
wiley +1 more source
An effort to use human-based exome capture methods to analyze chimpanzee and macaque exomes. [PDF]
PLoS ONE, 2012 Non-human primates have emerged as an important resource for the study of human disease and evolution. The characterization of genomic variation between and within non-human primate species could advance the development of genetically defined non-human ...
Xin Jin +34 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Inspired by conventional cell therapy and emerging bioengineering approaches, the tissue‐engineered nigrostriatal pathway (TE‐NSP) has an anatomically‐inspired design comprising a population of human dopaminergic neurons with unidirectional, long‐projecting axon tracts.
Wisberty J. Gordián‐Vélez +8 more
wiley +1 more source
Non-Human Primate Models of Tuberculosis
Microbiology Spectrum, 2016 ABSTRACT Among the animal models of tuberculosis (TB), the non-human primates, particularly rhesus macaques ( Macaca fascicularis ) and cynomolgus macaques ( Macaca mulatta ), share the greatest anatomical and physiological similarities with humans.
Juliet C, Peña, Wen-Zhe, Ho
openaire +2 more sources
Acta Pharmaceutica Sinica B, 2022 Unlike healthy, non-transformed cells, the proteostasis network of cancer cells is taxed to produce proteins involved in tumor development. Cancer cells have a higher dependency on molecular chaperones to maintain proteostasis.
Gan Wang +21 more
doaj +1 more source