Results 111 to 120 of about 17,406,766 (301)

A Multi-Regional Single-nucleus Atlas of the Huntington’s Disease Brain

Scientific Data
Huntington’s disease (HD) is a neurodegenerative disorder caused by an abnormal expansion of the CAG trinucleotide repeat sequence in the HTT gene. Research on HD, a rare condition, relies heavily on donations of post-mortem brain tissue, which are ...
Jiawei Li, Qin Zhou, Chunxiang Shi, Yingqi Lin, Bofeng Han, Jiale Gao, Jiacheng Li, Caijuan Li, Yizhi Chen, Chunhui Huang, Jianhao Wu, Wei Wang, Junzhu Song, Yuanpei Zhang, Qingqing He, Wentai Wang, Zhuchi Tu, Shihua Li, Xiao-Jiang Li, Bo Ning, Sen Yan   +20 more
doaj   +1 more source

The evolution of the primate cerebellum [PDF]

, 2001
Investigations into the evolution of the primate brain have consistently focussed on the neocortex as the principal area of change. New evidence is presented here to show that the cerebellum has also shown significant expansion over primate brain ...
Whiting, Bryony Anneke
core  

Evolution of Physical Intelligence Across Scales

Advanced Intelligent Discovery, EarlyView.
By following the evolution of physical intelligence across scales, this article shows how intelligence arises from materials, structures, physical interactions, and collectives. It establishes physical intelligence as the evolutionary foundation upon which embodied intelligence is built.
Ke Liu, Tianyun Huang, Aming Li, Pengyu Lv, Tingting Qin, Wenhui Chen, Hui Wei, Huiling Duan   +7 more
wiley   +1 more source

Reduced neural suppression at occipital cortex in subthreshold depression

Translational Psychiatry
Impaired visual perception and biochemical changes in the occipital cortex have been observed in major depression. However, the neural basis underlying these abnormalities remains yet elusive.
Jinhui Li, Yuheng Tan, Zixin Zheng, Chunliang Feng, Wenjie Fang, Xiaodan Huang, Song Lin, Kwok-Fai So, Lu Huang, Chaoran Ren, Qian Tao   +10 more
doaj   +1 more source

Splenic Tropism and Spleen‐Modulated Systemic Inflammation in Acute Plasmodium vivax Malaria

American Journal of Hematology, EarlyView.
ABSTRACT In chronic Plasmodium vivax (Pv) infection, the spleen accounts for over 98% of total‐body parasite biomass. Whether splenic tropism also occurs in acute infection and how the spleen influences pathogenesis have not been systematically explored. In Papua, Indonesia, we compared clinical and hematology data in 24 spleen‐intact and 25 previously
Steven Kho, Hasrini Rini, Noy N. Kambuaya, Syawal Satria, Freis Candrawati, Putu A. I. Shanti, King Alexander, Benediktus Andries, Aisah R. Amelia, Anjana Rai, Kim A. Piera, Agatha M. Puspitasari, Ristya Amalia, Pak Prayoga, Leo Leonardo, Maulina Hafidzah, Theo Situmorang, Dewi S. Margayani, Desandra A. Rahmayenti, Pengxing Cao, Enny Kenangalem, Leily Trianty, Damian Oyong, Julie A. Simpson, Rintis Noviyanti, Pierre A. Buffet, Jeanne R. Poespoprodjo, Nicholas M. Anstey   +27 more
wiley   +1 more source

Single-nucleus RNA sequencing dataset of diverse tissues from wild-type monkey and Tau-P301L transgenic monkey

Scientific Data
Utilizing non-human primates to study the role of human Tau and its related pathologies is logical and important due to their closer similarity to human brain structure and function.
Bofeng Han, Yan Chen, Weijie Ouyang, Danyi Chen, Jiawei Li, Weien Liang, Xudong Zhang, Chengxi Wei, Ling Liu, Sen Yan, Zhuchi Tu   +10 more
doaj   +1 more source

UBE3A Dosage Imbalance as a Molecular Framework Linking Angelman Syndrome and Dup15q‐Associated Autism Phenotypes

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT UBE3A is a dosage‐sensitive HECT E3 ubiquitin ligase whose neuronal expression is shaped by genomic imprinting at the 15q11.2‐q13 locus. Opposite directions of UBE3A dosage imbalance contribute to distinct neurodevelopmental phenotypes: loss of maternal UBE3A underlies Angelman syndrome, whereas maternally derived 15q11.2‐q13 copy‐number gains,
Ruslan Kurmashev
wiley   +1 more source

emmetaobrien/nhpatlas: NIH Blueprint Non-Human Primate Atlas

, 2019
<p>The NIH Blueprint Non-Human Primate (NHP) Atlas consists of a suite of gene expression and neuroanatomical data for exploring the cellular and molecular architecture of the developing rhesus macaque brain. This dataset contains datalad links for
Emmet A. O'Brien
core   +1 more source

Animal stroke models and outcome evaluation: A review

Animal Models and Experimental Medicine, EarlyView.
Rodents are the preeminent stroke model species. Large animal models exist too, but are poorly standardized. Ischemic and hemorrhagic experimental models are available, with the intraluminal filament model being predominant. Outcomes are evaluated via quantifying subjects' sensorimotor impairment, cognitive memory faculties, degree of cellular ...
Solsa Cariba, Helen M. Atkinson, Anthony K. C. Chan   +2 more
wiley   +1 more source

Non-human primates as a model for aging

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018
There has been, and continues to be, a dramatic shift in the human population towards older ages necessitating biomedical research aimed at better understanding the basic biology of aging and age-related diseases and facilitating new and improved therapeutic options.
openaire   +2 more sources